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Trehalose As a “Chemical Chaperone”

Fact and Fantasy

  • Chapter
Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 594))

Abstract

Trehalose is a disaccharide of glucose that is found at high concentrations in a wide variety of organisms that naturally survive drying in nature. Many years ago we reported that this molecule has the remarkable ability to stabilize membranes and proteins in the dry state. A mechanism for the stabilization rapidly emerged, and it was sufficiently attractive that a myth grew up about trehalose as a universal protectant and chemical chaperone. Many of the claims in this regard can be explained by what is now known about the physical properties of this interesting sugar. It is emerging that these properties may make it unusually useful in stabilizing intact cells in the dry state.

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Authors and Affiliations

  1. Section of Molecular and Cellular Biology, University of California, Davis, California, 95616, USA

    Dr. John H. Crowe

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  1. Dr. John H. Crowe
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Correspondence to John H. Crowe .

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Editors and Affiliations

  1. Department of Medical Chemistry, Semmelweis University, Budapest, Hungary

    Peter Csermely

  2. Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary

    László Vígh

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© 2007 Landes Bioscience and Springer Science+Business Media

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Crowe, J.H. (2007). Trehalose As a “Chemical Chaperone”. In: Csermely, P., Vígh, L. (eds) Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks. Advances in Experimental Medicine and Biology, vol 594. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39975-1_13

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