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Sonic Hedgehog Signalling during Tooth Morphogenesis

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Abstract

The Sonic hedgehog (Shh) peptide belongs to a small family of signalling molecules that have a complex mode of action and wide range of function during normal vertebrate development. In common with many regions of the embryo, Shh is expressed in the developing tooth in a regionally restricted manner. Specifically, Shh expression is localised to the epithelial component of the tooth germ at various stages during the odontogenic process; however, both tooth-forming epithelium and mesenchyme are responsive to the signal. A number of studies have analysed the role of Shh during tooth development, utilising both culture based and genetic systems, and it is dear that this signalling pathway is essential for normal development of the tooth. During the initiation of odontogenesis, localised signalling is important for growth and development of the tooth bud, whilst later during morphogenesis, Shh plays a role in cellular differentiation and polarization in the epithelial component of the tooth germ. These complex interactions are mediated by intra-epithelial and epithelial-mesenchymal signalling by Shh throughout these stages of tooth development.

Keywords

  • Sonic Hedgehog
  • Tooth Germ
  • Tooth Development
  • Oral Epithelium
  • Enamel Organ

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Cobourne, M.T., Miletich, I., Sharpe, P.T. (2006). Sonic Hedgehog Signalling during Tooth Morphogenesis. In: Shh and Gli Signalling and Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39957-7_7

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