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Role of Shh and Gli Signalling in Oligodendroglial Development

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Abstract

Recent molecular and genetic studies have demonstrated that early oligodendrocyte progenitor cells are induced from the ventral neural tube by the Sonic hedgehog (Shh) protein produced in the ventral midline structures. Whilst Shh signalling is required for ventral oligodendrogenesis in the entire central nervous system, Gli2 activity only regulates oligodendrocyte development in the ventral spinal cord. Gli3 plays a nonessential role in ventral oligodendrogenesis during normal development. However, in the absence of Shh signalling, Gli3 functions as a repressor of ventral oligodendrogenesis. In addition, there is growing evidence that a separate population of oligodendrocyte progenitor cells is also produced from the dorsal region of the neural tube independent of Shh signalling.

Keywords

Sonic Hedgehog Floor Plate Dorsal Spinal Cord Oligodendrocyte Differentiation Oligodendrocyte Lineage 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Department of Anatomical Sciences and Neurobiology, School of MedicineUniversity of LouisvilleLouisvilleUSA

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