Role of Hedgehog and Gli Signalling in Telencephalic Development

Part of the Molecular Biology Intelligence Unit book series (MBIU)


Studies performed over the last decade have significantly increased our understanding of the role of Hedgehog (Hh) signalling in brain development. Here, we review the various in vitro and in vivo studies demonstrating the importance of Hh signalling for dorsoventral patterning of the telencephalon. The use of conditional knockouts has been particularly helpful in defining the spatial and temporal requirements of Hh signalling during telencephalic development. We also discuss the primary effectors of Hh signalling, the Gli family of transcription factors, and focus on Gli3, which is particularly important for telencephalic development, as reflected in the severe telencephalic phenotype of Gli3 mutant mice. The presence of some dorsoventral patterning in animals lacking both Shh and GH3 implies that, although these molecules are major players in patterning the telencephalon, other patterning factors exist.


Neural Tube Sonic Hedgehog Neural Plate Medial Ganglionic Eminence Ventral Telencephalon 
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© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Genes and Development IDG, Section of Biomedical SciencesUniversity of EdinburghEdinburghUK

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