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New Perspectives in Shh Signalling?

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Shh and Gli Signalling and Development

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The Shh-Ptc signalling pathway and its components have been the subject of much research. Previous chapters of this book have illustrated the importance of this pathway and its activation in many aspects of development, regeneration of adult organs, and pathology. The role of Ptc as the primary receptor for Shh and its analogues has been emphasised in these chapters. However, there is mounting evidence that megalin [also known as glycoprotein 330 (gp330) or low-density lipoprotein receptor-related protein 2 (LPR2)], a 600kDa transmembrane glycoprotein belonging to the low density lipoprotein (LDL) receptor family, may be a second receptor for Shh. In this chapter I shall review this evidence; but I shall preface this discussion with an outline of the known properties and biological functions of megalin.

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  1. Immunobiology Group, MRC/UoE Centre for Inflammation Research, The Queen’s Medical Research Institute, Little France Crescent, Edinburgh, EH16 4TJ, Scotland, UK

    Carolyn E. Fisher

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© 2006 Landes Bioscience and Springer Science+Business Media

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Fisher, C.E. (2006). New Perspectives in Shh Signalling?. In: Shh and Gli Signalling and Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39957-7_14

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