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New Perspectives in Shh Signalling?

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Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

The Shh-Ptc signalling pathway and its components have been the subject of much research. Previous chapters of this book have illustrated the importance of this pathway and its activation in many aspects of development, regeneration of adult organs, and pathology. The role of Ptc as the primary receptor for Shh and its analogues has been emphasised in these chapters. However, there is mounting evidence that megalin [also known as glycoprotein 330 (gp330) or low-density lipoprotein receptor-related protein 2 (LPR2)], a 600kDa transmembrane glycoprotein belonging to the low density lipoprotein (LDL) receptor family, may be a second receptor for Shh. In this chapter I shall review this evidence; but I shall preface this discussion with an outline of the known properties and biological functions of megalin.

Keywords

Lung Development Heymann Nephritis Pulmonary Development LDLR Family Megalin Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Immunobiology Group, MRC/UoE Centre for Inflammation ResearchThe Queen’s Medical Research Institute, Little France CrescentEdinburghUK

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