Shh/Gli Signalling during Murine Lung Development

Part of the Molecular Biology Intelligence Unit book series (MBIU)


Murine lung development is a complex process regulated by many factors guiding a carefully orchestrated series of events leading to mature lung formation. Many developmental pathways have been implicated in governing proper lung formation. Most notably, the Shh/Gli pathway shown to be crucial to the development of numerous other organ systems, is an absolute requirement for correct lung formation. Many interactions between the Shh pathway and other fundamental lung signalling molecules such as fibroblast growth factor 10 (Fgf10) have presented themselves. While the specifics of these interactions have yet to be elucidated, the consequence of their actions is paramount in guiding lung development.


Sonic Hedgehog Lung Development Keratinocyte Growth Factor Fibroblast Growth Factor Signaling Lung Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Program in Lung Biology Research, The Hospital for Sick Children Research Institute, Institute of Medical SciencesUniversity of TorontoTorontoCanada

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