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Shh/Gli Signalling during Murine Lung Development

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Part of the Molecular Biology Intelligence Unit book series (MBIU)

Abstract

Murine lung development is a complex process regulated by many factors guiding a carefully orchestrated series of events leading to mature lung formation. Many developmental pathways have been implicated in governing proper lung formation. Most notably, the Shh/Gli pathway shown to be crucial to the development of numerous other organ systems, is an absolute requirement for correct lung formation. Many interactions between the Shh pathway and other fundamental lung signalling molecules such as fibroblast growth factor 10 (Fgf10) have presented themselves. While the specifics of these interactions have yet to be elucidated, the consequence of their actions is paramount in guiding lung development.

Keywords

Sonic Hedgehog Lung Development Keratinocyte Growth Factor Fibroblast Growth Factor Signaling Lung Phenotype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alescio T, Cassini A. Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 1962; 150:83–94.PubMedCrossRefGoogle Scholar
  2. 2.
    Spooner BS, Wessells NK. Mammalian lung development: Interactions in primordium formation and bronchial morphogenesis. J Exp Zool 1970; 175(4): 445–454.PubMedCrossRefGoogle Scholar
  3. 3.
    Shannon JM, Hyatt BA. Epithelial-mesenchymal interactions in the developing lung. Annu Rev Physiol 2004; 66:625–645.PubMedCrossRefGoogle Scholar
  4. 4.
    Bellusci S, Henderson R, Winnier G et al. Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. Development 1996; 122(6):1693–1702.PubMedGoogle Scholar
  5. 5.
    Litingtung Y, Lei L, Westphal H et al. Sonic hedgehog is essential to foregut development. Nat Genet 1998; 20(1):58–61.PubMedCrossRefGoogle Scholar
  6. 6.
    Bellusci S, Furuta Y, Rush MG et al. Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. Development 1997; 124(1):53–63.PubMedGoogle Scholar
  7. 7.
    Miller LA, Wert SE, Whitsett JA. Immunolocalization of sonic hedgehog (Shh) in developing mouse lung. J Histochem Cytochem 2001; 49(12):1593–1604.PubMedGoogle Scholar
  8. 8.
    Unger S, Copland I, Tibboel D et al. Down-regulation of sonic hedgehog expression in pulmonary hypoplasia is associated with congenital diaphragmatic hernia. Am J Pathol 2003; 162(2):547–555.PubMedGoogle Scholar
  9. 9.
    Grindley JC, Bellusci S, Perkins D et al. Evidence for the involvement of the Gli gene family in embryonic mouse lung development. Dev Biol 1997; 188(2):337–348.PubMedCrossRefGoogle Scholar
  10. 10.
    Chiang C, Litingtung Y, Lee E et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature 1996; 383(6599):407–413.PubMedCrossRefGoogle Scholar
  11. 11.
    Pepicelli CV, Lewis PM, McMahon AP. Sonic hedgehog regulates branching morphogenesis in the mammalian lung. Curr Biol 1998; 8(19):1083–1086.PubMedCrossRefGoogle Scholar
  12. 12.
    Miller LA, Wert SE, Clark JC et al. Role of Sonic hedgehog in patterning of tracheal-bronchial cartilage and the peripheral lung. Dev Dyn 2004; 231(1):57–71.PubMedCrossRefGoogle Scholar
  13. 13.
    Watsuji T, Okamoto Y, Emi N et al. Controlled gene expression with a reverse tetracycline-regulated retroviral vector (RTRV) system. Biochem Biophys Res Commun 1997; 234(3):769–773.PubMedCrossRefGoogle Scholar
  14. 14.
    Goodrich LV, Milenkovic L, Higgins KM et al. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997; 277(5329):1109–1113.PubMedCrossRefGoogle Scholar
  15. 15.
    Bergstein I, Leopold PL, Sato N et al. In vivo enhanced expression of patched dampens the sonic hedgehog pathway. Mol Ther 2002; 6(2):258–264.PubMedCrossRefGoogle Scholar
  16. 16.
    Chen Y, Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996; 87(3):553–563.PubMedCrossRefGoogle Scholar
  17. 17.
    Akiyama H, Shigeno C, Hiraki Y et al. Cloning of a mouse smoothened cDNA and expression patterns of hedgehog signalling molecules during chondrogenesis and cartilage differentiation in clonal mouse EC cells, ATDC5. Biochem Biophys Res Commun 1997; 235(1):142–147.PubMedCrossRefGoogle Scholar
  18. 18.
    Shannon JM, Srivastava K, Shangguan X et al. [C59] [Poster: G49] disruption of sonic hedgehog signaling alters patterning and gene expression in cultured embryonic lungs. Orlando, Florida, USA: Paper presented at: American Thoracic Society, 2004.Google Scholar
  19. 19.
    Goodrich LV, Johnson RL, Milenkovic L et al. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog. Genes Dev 1996; 10(3):301–312.PubMedCrossRefGoogle Scholar
  20. 20.
    Chuang PT, McMahon AP. Vertebrate Hedgehog signalling modulated by induction of a Hedgehog-binding protein. Nature 1999; 397(6720):617–621.PubMedCrossRefGoogle Scholar
  21. 21.
    Chuang PT, Kawcak T, McMahon AP. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hipl, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev 2003; 17(3):342–347.PubMedCrossRefGoogle Scholar
  22. 22.
    Hui CC, Slusarski D, Platt KA et al. Expression of three mouse homologs of the Drosophila segment polarity gene cubitus interruptus, Gli, Gli-2, and Gli-3, in ectoderm-and mesoderm-derived tissues suggests multiple roles during postimplantation development. Dev Biol 1994; 162(2):4O2–413.CrossRefGoogle Scholar
  23. 23.
    Park HL, Bai C, Platt KA et al. Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development 2000; 127(8):1593–1605.PubMedGoogle Scholar
  24. 24.
    Mo R, Freer AM, Zinyk DL et al. Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development 1997; 124(1):113–123.PubMedGoogle Scholar
  25. 25.
    Motoyama J, Liu J, Mo R et al. Essential function of Gli2 and Gli3 in the formation of lung, trachea and oesophagus. Nat Genet 1998; 20(1):54–57.PubMedCrossRefGoogle Scholar
  26. 26.
    Schimmang T, Lemaistre M, Vortkamp A et al. Expression of the zinc finger gene Gli3 is affected in the morphogenetic mouse mutant extra-toes (Xt). Development 1992; 116(3):799–804.PubMedGoogle Scholar
  27. 27.
    Li Y, Zhang H, Choi SC et al. Sonic hedgehog signaling regulates Gli3 processing, mesenchymal proliferation, and differentiation during mouse lung organogenesis. Dev Biol 2004; 270(1):214–231.PubMedCrossRefGoogle Scholar
  28. 28.
    King JA, Marker PC, Seung KJ et al. BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 1994; 166(1):112–122.PubMedCrossRefGoogle Scholar
  29. 29.
    Jena N, Martin-Seisdedos C, McCue P et al. BMP7 null mutation in mice: Developmental defects in skeleton, kidney, and eye. Exp Cell Res 1997; 230(1):28–37.PubMedCrossRefGoogle Scholar
  30. 30.
    Winnier G, Blessing M, Labosky PA et al. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev 1995; 9(17):2105–2116.PubMedCrossRefGoogle Scholar
  31. 31.
    Hogan BL, Yingling JM. Epithelial/mesenchymal interactions and branching morphogenesis of the lung. Curr Opin Genet Dev 1998; 8(4):481–486.PubMedCrossRefGoogle Scholar
  32. 32.
    Nogawa H, Ito T. Branching morphogenesis of embryonic mouse lung epithelium in mesenchyme-free culture. Development 1995; 121(4):1015–1022.PubMedGoogle Scholar
  33. 33.
    Post M, Souza P, Liu J et al. Keratinocyte growth factor and its receptor are involved in regulating early lung branching. Development 1996; 122(10):3107–3115.PubMedGoogle Scholar
  34. 34.
    Cardoso WV, Itoh A, Nogawa H et al. FGF-1 and FGF-7 induce distinct patterns of growth and differentiation in embryonic lung epithelium. Dev Dyn 1997; 208(3):398–405.PubMedCrossRefGoogle Scholar
  35. 35.
    Simonet WS, DeRose ML, Bucay N et al. Pulmonary malformation in transgenic mice expressing human keratinocyte growth factor in the lung. Proc Natl Acad Sci USA 1995; 92(26):12461–12465.PubMedCrossRefGoogle Scholar
  36. 36.
    Guo L, Degenstein L, Fuchs E. Keratinocyte growth factor is required for hair development but not for wound healing. Genes Dev 1996; 10(2):165–175.PubMedCrossRefGoogle Scholar
  37. 37.
    Bellusci S, Grindley J, Emoto H et al. Fibroblast growth factor 10 (FGF 10) and branching morphogenesis in the embryonic mouse lung. Development 1997; 124(23):4867–4878.PubMedGoogle Scholar
  38. 38.
    Chapman DL, Garvey N, Hancock S et al. Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn 1996; 206(4):379–390.PubMedCrossRefGoogle Scholar
  39. 39.
    Cebra-Thomas JA, Bromer J, Gardner R et al. T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Dev Dyn 2003; 226(1):82–90.PubMedCrossRefGoogle Scholar
  40. 40.
    Sekine K, Ohuchi H, Fujiwara M et al. Fgf 10 is essential for limb and lung formation. Nat Genet 1999; 21(1):138–141.PubMedCrossRefGoogle Scholar
  41. 41.
    Lebeche D, Malpel S, Cardoso WV. Fibroblast growth factor interactions in the developing lung. Mech Dev 1999; 86(1–2):125–136.PubMedCrossRefGoogle Scholar
  42. 42.
    Rice R, Spencer-Dene B, Connor EC et al. Disruption of Fgf10/Fgfr2b-coordinated epithelial-mesenchymal interactions causes cleft palate. J Clin Invest 2004; 113(12):1692–1700.PubMedGoogle Scholar
  43. 43.
    van Tuyl M, Post M. From fruitflies to mammals: Mechanisms of signalling via the Sonic hedgehog pathway in lung development. Respir Res 2000; 1(1):30–35.PubMedCrossRefGoogle Scholar
  44. 44.
    Arman E, Haffner-Krausz R, Chen Y et al. Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc Natl Acad Sci USA 1998; 95(9):5082–5087.PubMedCrossRefGoogle Scholar
  45. 45.
    Deng CX, Wynshaw-Boris A, Shen MM et al. Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev 1994; 8(24):3045–3057.PubMedCrossRefGoogle Scholar
  46. 46.
    Yamaguchi TP, Harpal K, Henkemeyer M et al. fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev 1994; 8(24):3032–3044.PubMedCrossRefGoogle Scholar
  47. 47.
    Colvin JS, Bohne BA, Harding GW et al. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3. Nat Genet 1996; 12(4):390–397.PubMedCrossRefGoogle Scholar
  48. 48.
    Weinstein M, Xu X, Ohyama K et al. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development 1998; 125(18):3615–3623.PubMedGoogle Scholar
  49. 49.
    Arman E, Haffner-Krausz R, Gorivodsky M et al. Fgfr2 is required for limb outgrowth and lung-branching morphogenesis. Proc Natl Acad Sci USA 1999; 96(21):11895–11899.PubMedCrossRefGoogle Scholar

Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Program in Lung Biology Research, The Hospital for Sick Children Research Institute, Institute of Medical SciencesUniversity of TorontoTorontoCanada

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