Sonic Hedgehog Signalling in Visceral Organ Development

Part of the Molecular Biology Intelligence Unit book series (MBIU)


The secreted signalling molecule encoded by Sonic hedgehog (Shh) has been shown to play an indispensable role in mammalian organogenesis. During embryonic development, one of the prominent sites of Shh expression is in the tubular gut endoderm and its derivatives such as the esophagus, lung, stomach and intestine. Loss of Shh function results in profound growth and patterning defects of the gastrointestinal tract and associated organs. Furthermore, misregulation of Shh signalling in human patients has been implicated in a variety of gastrointestinal tumors. In this chapter, we will discuss studies that reveal the critical roles of Shh signalling in mammalian visceral organ development and homeostasis.


Sonic Hedgehog Glandular Stomach Pancreas Development Smooth Muscle Differentiation Zymogenic Cell 
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Copyright information

© Landes Bioscience and Springer Science+Business Media 2006

Authors and Affiliations

  1. 1.Department of Cell and Developmental BiologyVanderbilt University Medical CenterNashvilleUSA

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