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Sonic Hedgehog Signalling in Visceral Organ Development

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Shh and Gli Signalling and Development

Part of the book series: Molecular Biology Intelligence Unit ((MBIU))

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Abstract

The secreted signalling molecule encoded by Sonic hedgehog (Shh) has been shown to play an indispensable role in mammalian organogenesis. During embryonic development, one of the prominent sites of Shh expression is in the tubular gut endoderm and its derivatives such as the esophagus, lung, stomach and intestine. Loss of Shh function results in profound growth and patterning defects of the gastrointestinal tract and associated organs. Furthermore, misregulation of Shh signalling in human patients has been implicated in a variety of gastrointestinal tumors. In this chapter, we will discuss studies that reveal the critical roles of Shh signalling in mammalian visceral organ development and homeostasis.

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Authors and Affiliations

  1. Department of Cell and Developmental Biology, Vanderbilt University Medical Center, 465 21st Ave. South, Nashville, Tennessee, 37232, USA

    Huimin Zhang, Ying Litingtung & Chin Chiang

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  1. Huimin Zhang
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  2. Ying Litingtung
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  3. Chin Chiang
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© 2006 Landes Bioscience and Springer Science+Business Media

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Zhang, H., Litingtung, Y., Chiang, C. (2006). Sonic Hedgehog Signalling in Visceral Organ Development. In: Shh and Gli Signalling and Development. Molecular Biology Intelligence Unit. Springer, New York, NY. https://doi.org/10.1007/978-0-387-39957-7_12

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