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Genomic Variation and Autoimmune Disease

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Book cover Immunogenetics of Autoimmune Disease

Part of the book series: Medical Intelligence Unit ((MIUN))

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Abstract

Genetic epidemiology is the study of the relationship between genomic and phenotypic variation with a goal to uncover the genetic basis of monogenic or complex disorders. A variety of study designs are available, and the importance of choosing an approach that is appropriate for the goals of the study cannot be over-emphasized. In addition to study design, important issues include selection of genetic marker type and number of markers to be tested, as well as the use of genotyping technology. In this chapter, we review these important features of genetic epidemiology studies with particular emphasis on applications to autoimmune conditions.

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Authors and Affiliations

  1. Department of Medicine Center for Human Genetics, Duke University Medical Center, Durham, North Carolina, USA

    Silke Schmidt

  2. Division of Epidemiology School of Public Health, University of California, Berkeley, California, USA

    Lisa F. Barcellos

Authors
  1. Silke Schmidt
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  2. Lisa F. Barcellos
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© 2006 Landes Bioscience and Springer Science+Business Media

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Schmidt, S., Barcellos, L.F. (2006). Genomic Variation and Autoimmune Disease. In: Immunogenetics of Autoimmune Disease. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-39926-3_2

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