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Minimally Invasive Radioguided Parathyroidectomy in Primary Hyperparathyroidism

  • Chapter
Radioguided Surgery

Abstract

Primary hyperparathyroidism is caused by inappropriately high secretion of parathyroid hormone (PTH) by 1 or more enlarged parathyroid glands (1). Diagnosis of primary hyperparathyroidism, especially the asymptomatic form, has dramatically increased worldwide, mainly due to the introduction of automated serum calcium measurement in laboratory screening (2),(3). The prevalence of primary hyperparathyroidism in a United States community has increased from about 0.08/1000 to about 0.5/1000, with the proportion of asymptomatic patients rising from 18% to 51% (3). Other United States estimates place the prevalence of primary hyperparathyroidism at 2/1000 women and 0.5/1000 men over age 40 (4). Parallel European estimates in the 1980s indicated an average 10/1000 prevalence in the general population (about 0.3/1000 for men and about 17/1000 for women, with a peak of 33/1000 for women older than 60 years) (5). However, it seems that after such an initial “catch-up effect,” this surge in the identification of primary hyperparathyroidism has plateaued or is actually declining, as indicated by the most recent estimates both in the United States (with the annual incidence decreasing in the last decade from 75/100,000 to about 20/100,000) and in Europe (with the present prevalence of 3/1000 in the general population and 21/1000 in women age 55 to 75) (6),(7).

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Authors and Affiliations

  1. Norman Endocrine Surgery Clinic, Tampa, FL, USA

    James Norman MD

  2. Nuclear Medicine Service, PET Center, S. Maria della Misericordia Hospital, Istituto Oncologico Veneto (IOV), Rovigo, Italy

    Domenico Rubello MD

  3. John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, CA, USA

    Armando E. Giuliano MD (Chief of Science and Medicine)

  4. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Giuliano Mariani MD

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  1. James Norman MD
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  2. Domenico Rubello MD
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  3. Armando E. Giuliano MD
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Editors and Affiliations

  1. Regional Center of Nuclear Medicine, University of Pisa Medical School, Pisa, Italy

    Giuliano Mariani MD

  2. John Wayne Cancer Institute, Saint John’s Health Center, Santa Monica, California, USA

    Armando E. Giuliano MD (Chief of Science and Medicine) (Chief of Science and Medicine)

  3. Nuclear Medicine Service, Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA

    H. William Strauss MD

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Norman, J., Rubello, D., Giuliano, A.E., Mariani, G. (2008). Minimally Invasive Radioguided Parathyroidectomy in Primary Hyperparathyroidism. In: Mariani, G., Giuliano, A.E., Strauss, H.W. (eds) Radioguided Surgery. Springer, New York, NY. https://doi.org/10.1007/978-0-387-38327-9_23

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  • DOI: https://doi.org/10.1007/978-0-387-38327-9_23

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