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Bt Corn’s Reduction of Mycotoxins: Regulatory Decisions and Public Opinion

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Regulating Agricultural Biotechnology: Economics and Policy

Part of the book series: Natural Resource Management and Policy ((NRMP,volume 30))

Abstract

This chapter analyzes the impact of mycotoxins—toxic and carcinogenic chemicals produced by fungi—in corn, primarily in terms of global trade and health considerations to major corn exporters and importers. It then discusses the state of the evidence for genetically modified Bt corn reducing contamination levels of various mycotoxins, and the implications for human health and markets worldwide. Finally, it speculates on the role that mycotoxin reduction may or may not play in regulatory decisions on commercialization and trade of Bt corn, both today and in the future.

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References

  • Bakan, B., D. Melcion, D, Richard-Molard, and B. Cahagnier. 2002. “Fungal Growth and Fusarium Mycotoxin Content in Isogenic Traditional Maize and Genetically Modified Maize Grown in France and Spain.” Journal of Agricultural and Food Chemistry 50(4): 728–731.

    Article  PubMed  CAS  Google Scholar 

  • Benedict, J., D. Fromme, J. Cosper, C. Correa, G. Odvody, and R. Parker. 1998. “Efficacy of Bt Corn Events MON810, Bt l1 and E176 in Controlling Com Earworm, Fall Armyworm, Sugarcane Borer and Aflatoxin.” Texas A&M University System, College Station, TX (available online at http://lubbock.tamu.edu/ipm/AgWeb/r_and_d/1998/Roy%20Parker/[-]Bt%20Corn/BtCorn.html).

    Google Scholar 

  • Buntin, G.D., R.D. Lee, D.M. Wilson, and R.M. McPherson. 2001. “Evaluation of Yieldgard Transgenic Resistance for Control of Fall Armyworm and Corn Earworm (Lepidoptera: Noctuidae) on Corn.” Florida Entomologist 84(1): 37–42.

    Article  Google Scholar 

  • Cardwell, K.F., A. Desjardins, S.H. Henry, G. Munkvold, and J. Robens. 2001. Mycotoxins: The Cost of Achieving Food Security and Food Quality (available online at www.apsnet.org/online/feature/mycotoxin/top.html).

    Google Scholar 

  • Carpenter, J.E. 2001. “Case Studies in Benefits and Risks of Agricultural Biotechnology: Roundup Ready Soybeans and Bt Field Corn.” National Center for Food and Agricultural Policy, Washington, D.C. (available online at www.ncfap.org/pup/biotech/benefitsandrisks.pdf).

    Google Scholar 

  • Council for Agricultural Science and Technology. 2003. Mycotoxins: Risks in Plant, Animal, and Human Systems. Task Force Report No. 139, Ames, Iowa.

    Google Scholar 

  • Dowd, P.F. 1998. “The Involvement of Arthropods in the Establishment of Mycotoxigenic Fungi Under Field Conditions.” In K. Sinha and D. Bhatnagar, eds., Mycotoxins in Agriculture and Food Safety. New York: Marcel Dekker.

    Google Scholar 

  • ____. 2001. “Biotic and Abiotic Factors Limiting Efficacy of Bt Corn in Indirectly Reducing Mycotoxin Levels in Commercial Fields.” Journal of Economic Entomology 94(5): 1067–1074.

    Article  PubMed  CAS  Google Scholar 

  • EPA [see U.S. Environmental Protection Agency].

    Google Scholar 

  • Etcheverry, M., A. Nesci, G. Barros, A. Torres, and S. Chulze. 1999. “Occurrence of Aspergillus Section Flavi and Aflatoxin Bl in Corn Genotypes and Corn Meal in Argentina.” Mycopathologia 147(1): 37–41.

    Article  PubMed  CAS  Google Scholar 

  • FDA [see U.S. Food and Drug Administration].

    Google Scholar 

  • Food Standards Agency (FSA). 2003. “Contaminated Maize Meal Withdrawn from Sale” (available online at www.food.gov.uk/news/newsarchive/maize).

    Google Scholar 

  • Gong, Y.Y., K. Cardwell, A. Hounsa, S. Egal, P.C. Turner, A.J. Hall, and C.P. Wild. 2000. “Dietary Aflatoxin Exposure and Impaired Growth in Young Children from Benin and Togo: Cross Sectional Study.” British Medical Journal 325(7354): 20–21.

    Article  Google Scholar 

  • Hammond, B., K. Campbell, C. Pilcher, A. Robinson, D. Melcion, B. Cahagnier, J. Richard, J. Sequeira, J. Cea, F. Tatli, R. Grogna, A. Pietri, G. Piva, and L. Rice. 2003. “Reduction of Fumonisin Mycotoxins in Bt Corn.” The Toxicologist 72(S-1): 1217.

    Google Scholar 

  • Hendricks, K. 1999. “Fumonisins and Neural Tube Defects in South Texas.” Epidemiology 10(2): 198–200.

    Article  PubMed  CAS  Google Scholar 

  • Henry, S.H., F.X. Bosch, T.C. Troxell, and P.M. Bolger. 1999. “Reducing Liver Cancer: Global Control of Aflatoxin.” Science 286(5449): 2453–2454.

    Article  PubMed  CAS  Google Scholar 

  • IARC [see International Agency for Research on Cancer].

    Google Scholar 

  • International Agency for Research on Cancer (IARC). 2002. Some Traditional Herbal Medicines, Some Mycotoxins, Naphthalene and Styrene. Monograph Volume 82, IARC, Lyon, France (available online at http://monographs.iarc.fr/htdocs/indexes/vol82index.html).

    Google Scholar 

  • International Programme on Chemical Safety (IPCS). 1999. Environmental Health Criteria 217: Microbial Pest Control Agent Bacillus thuringiensis. World Health Organization, Geneva, Switzerland.

    Google Scholar 

  • Jaffe, G. 2004. “Regulating Transgenic Crops: A Comparative Analysis of Different Regulatory Processes.” Transgenic Research 13(1): 5–19.

    Article  PubMed  CAS  Google Scholar 

  • James, C. 2003. Global Review of Commercialized Transgenic Crops: 2002. Feature: Bt Maize. International Service for the Acquisition of Agri-Biotech Applications (1SAAA) No. 29, Ithaca, NY.

    Google Scholar 

  • JECFA [see Joint FAO/WHO Expert Committee on Food Additives].

    Google Scholar 

  • Joint FAO/WHO Expert Committee on Food Additives (JECFA). 2001. “Safety Evaluation of Certain Mycotoxins in Food.” WHO Food Additives Series 47, FAO Food and Nutrition Paper 74, WHO/FAO, Geneva.

    Google Scholar 

  • Keyl, A.C. 1978. “Aflatoxicosis in Cattle.” In T.D. Wyllie and L.G. Morehouse, eds., Mycotoxic Fungi, Mycotoxins, Mycotoxicoses (Vol. 2). New York: Marcel Dekker.

    Google Scholar 

  • Li, F.Q., T. Yoshiazawa, O. Kawamura, X.Y. Luo, and Y.W. Li. 2001. “Aflatoxins and Fumonisins in Corn from the High-Incidence Area for Human Hepatocellular Carcinoma in Guangxi, China.” Journal of Food and Agricultural Chemistry 49(8): 4122–4126.

    Article  CAS  Google Scholar 

  • Lubulwa, A.S.G., and J.S. Davis. 1994. “Estimating the Social Costs of the Impacts of Fungi and Aflatoxins in Maize and Peanuts.” In E. Highley, E.J. Wright, H.J. Banks, and B.R. Champ, eds., Stored Product Protection: Proceedings of the 6th International Working Conference on Stored-product Protection. Wallingford, UK: CAB International.

    Google Scholar 

  • Marasas, W.F.O. 1996. “Fumonisins: History, World-Wide Occurrence and Impact.” In L. Jackson, ed., Fumonisins in Food. New York: Plenum Press.

    Google Scholar 

  • Marasas, W.F.O., R.L. Riley, K.A. Hendricks, V.L. Stevens, T.W. Sadler, J. Gelineau-van Waes, S.A. Missmer, J. Cabrera, O. Torres, W.C.A. Gelderblom, J. Allegood, C. Martinez, J. Maddox, J.D. Miller, L. Starr, M.C. Sullards, A.V. Roman, K.A. Voss, E. Wang, and A.H. Merrill, Jr. 2004. “Fumonisins Disrupt Sphingolipid Metabolism, Folate Transport, and Neural Tube Development in Embryo Culture and in vivo: A Potential Risk Factor for Human Neural Tube Defects Among Populations Consuming Fumonisin-Contaminated Maize.” Journal of Nutrition 134(4): 711–716.

    PubMed  CAS  Google Scholar 

  • Miller, J.D. 1995. “Fungi and Mycotoxins in Grain: Implications for Stored Product Research.” Journal of Stored Product Research 31(1): 1–16.

    Article  CAS  ADS  Google Scholar 

  • ____. 2001. “Factors That Affect the Occurrence of Fumonisins.” Environmental Health Perspective 109(Supplement 2): 321–324.

    Article  CAS  Google Scholar 

  • Miller, J.D., and W.F.O. Marasas. 2002. “Ecology of Mycotoxins in Maize and Groundnuts.” Supplement to LEISA (Low External Input and Sustainable Agriculture) Magazine (March): 23–24.

    Google Scholar 

  • Munkvold, G.P. 2001. “Potential Impact of FDA Guidelines for Fumonisins in Foods and Feeds.” In Mycotoxins: The Cost of Achieving Food Security and Food Quality. American Phtopathological Society, St. Paul, MN (available online at www.apsnet.org/online/fea[-]ture/mycotoxin/top.html) (accessed May 2004).

    Google Scholar 

  • Munkvold, G.P., and R.L. Hellmich. 1999. “Comparison of Fumonisin Concentrations in Kernels of Transgenic Bt Maize Hybrids and Nontransgenic Hybrids.” Plant Disease 83(2): 130–138.

    Article  Google Scholar 

  • Nap, J.P., P.L.J. Metz, M. Escaler, and A.J. Conner. 2003. “The Release of Genetically Modified Crops into the Environment, Part I: Overview of Current Status and Regulations.” The Plant Journal 33(1): 1–18.

    Article  PubMed  Google Scholar 

  • National Academy of Sciences. 2000. Genetically Modified Pest-Protected Plants: Science and Regulation. Washington, D.C.: National Academy Press.

    Google Scholar 

  • Odvody, G.N., C.F. Chilcutt, R.R. Parker, and J.H. Benedict. 2000. “Aflatoxin and Insect Response of Near-lsogenic Bt and non-Bt Commercial Corn Hybrids in South Texas.” In J.F. Robens, ed., Proceedings of the 2000 Aflatoxin/Fumonisin Workshop. Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD.

    Google Scholar 

  • Paarlberg, R. 2001. The Politics of Precaution: Genetically Modified Crops in Developing Countries. Baltimore, MD: International Food Policy Research Institute.

    Google Scholar 

  • Pray, C.E., J. Huang, R. Hu, Q. Wang, B. Ramaswami, and P. Bengali. 2006. “Benefits and Costs of Biosafety Regulation in India and China.” In R.E. Just, J.M. Alston, and D. Zilberman, eds., Regulating Agricultural Biotechnology: Economics and Policy. New York: Springer.

    Google Scholar 

  • Resnik, S., S. Neira, A. Pacin, E. Martinez, N. Apro, and S. Latreite. 1996. “A Survey of the Natural Occurrence of Aflatoxins and Zearalenone in Argentine Field Maize: 1983–1994.” Food Additives and Contaminants 13(1): 115–120.

    PubMed  CAS  Google Scholar 

  • Rheeder, J.P., W.F. Marasas, and H.F. Vismer. 2002. “Production of Fumonisin Analogs by Fusarium Species.” Applied Environmental Microbiology 68(5): 2101–2105.

    Article  CAS  Google Scholar 

  • Robens, J., and K. Cardwell. 2003. “The Costs of Mycotoxin Management to the USA: Management of Aflatoxins in the United States.” Journal of Toxicology: Toxin Reviews 22(2–3): 143–156.

    Google Scholar 

  • Ross, P.F., L.G. Rice, G.D. Osweiler, P.E. Nelson, J.L. Richard, and T.M. Wilson. 1992. “A Review and Update of Animal Toxicoses Associated with Fumonisin-Contaminated Feeds and Production of Fumonisins by Fusarium Isolates.” Mycopathologia 17(1–2): 109–114.

    Article  Google Scholar 

  • Shelby, R.A., O.G. White, and E.M. Burke. 1994. “Differential Fumonisins Production in Maize Hybrids.” Plant Disease 78(6): 582–584.

    Article  CAS  Google Scholar 

  • Shephard, G.S. 2004. “Mycotoxins Worldwide: Current Issues in Africa.” In D. Barug, H.P. van Egmond, R. Lopez-Garcia, W.A. van Osenbruggen, and A. Visconti, eds., Meeting the Mycotoxin Menace. Wageningen, the Netherlands: Wageningen Academic.

    Google Scholar 

  • Sinha, A.K. 1994. “The Impact of Insect Pests on Aflatoxin Contamination of Stored Wheat and Maize.” In E. Highley, E.J. Wright, H.J. Banks, and B.R. Champ, eds., Stored Product Protection: Proceedings of the 6th International Working Conference on Storedproduct Protection. Wallingford, UK: CAB International.

    Google Scholar 

  • Sydenham, E.W., G.S. Shephard, P.G. Thiel, W.F.O. Marasas, and S. Stockenstrom. 1991. “Fumonisin Contamination of Commercial Corn-Based Human Foodstuffs.” Journal of Agricultural Food Chemistry 39(11): 2014–2018.

    Article  CAS  Google Scholar 

  • Turner, P.C., S.E. Moore, A.J. Hall, A.M. Prentice, and C.P. Wild. 2003. “Modification of Immune Function Through Exposure to Dietary Aflatoxin in Gambian Children.” Environmental Health Perspectives 111(2): 217–220.

    Article  PubMed  CAS  Google Scholar 

  • U.S. Department of Agriculture. 2003a. World Corn Trade. Foreign Agricultural Service, Production, Supply and Distribution.

    Google Scholar 

  • ____. 2003b. World Coarse Grains Situation and Outlook. Foreign Agricultural Service (available online at http://www.fas.usda.gov/grain/circular/2003/10-03/cgra_txt.htm).

    Google Scholar 

  • ____. 2004. Acreage. USDA National Agricultural Statistics Service, Agricultural Statistics Board, Washington, D.C.

    Google Scholar 

  • U.S. Food and Drug Administration. 2000. “Background Paper in Support of Fumonisin Levels in Corn and Corn Products Intended for Human Consumption” (available online at http://www.cfsan.fda.gov/~dms/fumonbg3.html).

    Google Scholar 

  • U.S. Environmental Protection Agency. 2001. Biopesticides Registration Action Document (BRAD)—Bacillus thuringiensis Plant-Incorporated Protectants. Available online at www.epa.gov/pesticides/biopesticides/pips/bt_brad.htm.

    Google Scholar 

  • van Egmond, H.P. 2002. “Worldwide Regulations for Mycotoxins.” Advances in Experimental Medical Biology 504: 257–269.

    Google Scholar 

  • Wang, J.S., T. Huang, J. Su, F. Liang, Z. Wei, Y. Liang, H. Luo, S.Y. Kuang, G.S. Qian, G. Sun, X. He, T.W. Kensler, and J.D. Groopman. 2001. “Hepatocellular Carcinoma and Aflatoxin Exposure in Zhuqing Village, Fusui County, People’s Republic of China.” Cancer Epidemiological Markers 10(2): 143–146.

    CAS  Google Scholar 

  • Wicklow, D.T. 1994. “Preharvest Origins of Toxigenic Fungi in Stored Grain.” In E. Highley, E.J. Wright, H.J. Banks, and B.R. Champ, eds., Stored Product Protection: Proceedings of the 6th International Working Conference on Stored-product Protection. Wallingford, UK: CAB International.

    Google Scholar 

  • Williams, W.P., G.L. Windham, P.M. Buckley, and C.A. Daves. 2002. “Aflatoxin Accumulation in Conventional and Transgenic Corn Hybrids Infested with Southwestern Corn Borer (Lepidoptera: Crambidae).” Journal of Agricultural and Urban Entomology 19(4): 227–236.

    Google Scholar 

  • Windham, G.L., W.P. Williams, and F.M. Davis. 1999. “Effects of the Southwestern Corn Borer on Aspergillus flavus Kernel Infection and Aflatoxin Accumulation in Maize Hybrids.” Plant Disease 83(6): 535–540.

    Article  Google Scholar 

  • Wu, F. 2004. “Mycotoxin Risk Assessment for the Purpose of Setting International Regulatory Standards.” Environmental Science and Technology 38(15): 4049–4055.

    Article  PubMed  CAS  Google Scholar 

  • Wu, F., J.D. Miller, and E.A. Casman. 2004. “Bt Corn and Mycotoxin Reduction: An Economic Perspective.” Journal of Toxicology, Toxin Reviews 23(2–3): 397–424.

    Article  CAS  Google Scholar 

  • Wyatt, R.D. 1991. “Poultry.” In J.E. Smith and R.S. Henderson, eds., Mycotoxins and Animal Foods. Boca Raton, FL: CRC Press.

    Google Scholar 

  • Yoshizawa, T., A. Yamashita, and Y. Luo. 1994. “Fumonisin Occurrence in Corn from High-and Low-Risk Areas for Human Esophageal Cancer in China.” Applied and Environmental Microbiology 60(5): 1626–1629.

    PubMed  CAS  Google Scholar 

  • Zhang, J.Y., X. Wang, S.G. Han, and H. Zhuang. 1998. “A Case-Control Study of Risk Factors for Hepatocellular Carcinoma in Henan, China.” American Journal of Tropical Medicine and Hygiene 59(6): 947–951.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Graduate School of Public Health, University of Pittsburgh, Pittsburgh

    Felicia Wu

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  1. Felicia Wu
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Editors and Affiliations

  1. University of Maryland, USA

    Richard E. Just

  2. University of California, Davis

    Julian M. Alston

  3. University of California, Berkeley

    David Zilberman

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Wu, F. (2006). Bt Corn’s Reduction of Mycotoxins: Regulatory Decisions and Public Opinion. In: Just, R.E., Alston, J.M., Zilberman, D. (eds) Regulating Agricultural Biotechnology: Economics and Policy. Natural Resource Management and Policy, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36953-2_9

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