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Advanced Image-Guided External Beam Radiotherapy

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Radiation Oncology Advances

Part of the book series: Cancer Treatment and Research ((CTAR,volume 139))

In 2003, Schultz and Kagan speculated that even with a perfect ability to deliver the ideal radiation dose distribution, it would be unlikely that outcomes would be improved. They imagined a perfect radiation treatment machine, which they called the “Infinitron,” that could deliver a dose distribution with any dose level and a zero dose outside of the target volume. They proposed that the Infinitron might not be preferable to surgery except for the reduced morbidity that would accompany its use. Schultz and Kagan were overly pessimistic as their argument that better radiation technology would not affect cure was easily countered by Keall and Williamson (2003) who provided several examples to the contrary. However, Schultz and Kagan (2003) were correct on one point; without the knowledge of where the disease is and where it is not present, the Infinitron could not guarantee a cure. As more and better treatment systems to deliver radiation come into existence, the key to their use will be to identify the target volume more exactly and to ensure that the targeted region is treated as prescribed.

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Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4/310, 53792, Madison, WI, USA

    Thomas Rockwell Mackie Ph.D & Associate Professor Wolfgang A. Tomé M.D., Ph.D

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  1. Thomas Rockwell Mackie Ph.D
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  2. Associate Professor Wolfgang A. Tomé M.D., Ph.D
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  1. University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4/310, 53792, Madison, WI, USA

    Søren M. Bentzen Ph.D., D.Sc , Paul M. Harari M.D , Wolfgang A. Tomé M.D., Ph.D  & Minesh P. Mehta M.D , ,  & 

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Mackie, T.R., Tomé, W.A. (2008). Advanced Image-Guided External Beam Radiotherapy. In: Bentzen, S.M., Harari, P.M., Tomé, W.A., Mehta, M.P. (eds) Radiation Oncology Advances. Cancer Treatment and Research, vol 139. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36744-6_2

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