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Intracellular Signaling and Synaptic Plasticity

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References

  1. Quirion R, Bowen WD, Itzhak Y, Junien JL, Musacchio JM, Rothman RB, Su TP, Tam SW, Taylor DP. Classification of o binding sites: a proposal. Trends Pharmacol Sci 1992, 1385–86.

    Article  PubMed  CAS  Google Scholar 

  2. Walker JM, Bowen WD, Walker FO, Matsumoto RR, De Costa BR, Rice KC. Sigma receptors: biology and function. Pharmacol Rev 1990, 42:355–402.

    PubMed  CAS  Google Scholar 

  3. Hanner M, Moebius FF, Flandorfer A, Knaus H-G, Striessnig J, Kemper E, Glossmann H. Purification, molecular cloning, and expression of the mammalian 0,-binding site. Proc Natl Acad Sci USA 1996, 93:8072–8077.

    Article  PubMed  CAS  Google Scholar 

  4. Kekuda R, Prasad PD, Fei YJ, Leibach FH, Ganapathy V. Cloning and functional expression of the human type 1 σ receptor (hSigmaR1). Biochem Biophys Res Commun 1996, 229:553–558.

    Article  PubMed  CAS  Google Scholar 

  5. Jbilo 0, Vidal H, Paul R, de Nyst N, Bensaid M, Silve S, Carayon P, Davi D, Galibgue S, Bourri C B, Guillemot JC, Ferrara P, Loison G, Maffrand JP, LeFur G, Casellas P. Purification and characterization of the human SR-3 1747A-binding protein. J Biol Chem 1997, 272:27107–27115.

    Article  PubMed  CAS  Google Scholar 

  6. Martin WR, Eades CG, Thompson JA, Huppler RE, Gilbert PE. The effects of morphine and nalorphine like drugs in the non dependent and morphine dependent chronic spinal dog. J Pharmacol Exp Ther 1976, l97:517–532.

    Google Scholar 

  7. Hayashi T, Su TP. Sigma-1 receptor ligands: potential in the treatment of neuropsychiatric disorders. CNS Drugs 2004, 18:269–284.

    Article  PubMed  CAS  Google Scholar 

  8. Itzhak Y. Multiple affinity binding states of the σ receptor: effect of GTP-binding protein-modifying agents. Mol Pharmacol 1989, 36512–517.

    PubMed  CAS  Google Scholar 

  9. Monnet FP, Debonnel G, de Montigny C. Potentiation by haloperidol of the antagonism by MK 801 of the excitatory effect of dicarboxylic amino acids: an electrophysiological study in the rat dorsal hippocampus. Soc Neurosci Abst 1988, 14:38 1.14.

    Google Scholar 

  10. Monnet FP, Debonnel G, Junien JL, de Montigny C. N-methyl-D-aspartate-induced neuronal activation is selectively modulated by 0 receptors. Eur J Pharmacol 1990, 179:441–445.

    Article  PubMed  CAS  Google Scholar 

  11. Golstein SR, Matsumoto RR, Thomson TL, Patrick RL, Bowen WD, Walker JM. Motor effects of two a ligands mediated by nigrostriatal dopamine neurons. Synapse 1989, 4:254–258.

    Article  Google Scholar 

  12. Iyengar S, Mick S, Dilworth V, Michel J, Rao TS, Farah JM, Wood PL. o receptors modulate the hypothalamic-pituitary-adrenal (HPA) axis centrally: evidence for a functional interaction with NMDA receptors, in vivo. Neuropharmacology 1990, 29:299–303.

    Article  PubMed  CAS  Google Scholar 

  13. Rogers CA, Lemaire S. Role of the σ receptor in the inhibition of [3H]noradrenaline uptake in brain synaptosomes and adrenal chromaffin cells. Br J Pharmacol 1991, 103:1917–1922.

    PubMed  CAS  Google Scholar 

  14. Kim MB, Bickford PC. Electrophysiological effects of phencyclidine and the o agonist ditolylguanidine in the cerebellum of the rat. Neuropharmacology 1992, 31:77–83.

    Article  PubMed  CAS  Google Scholar 

  15. Bowen WD, Kirschner BN, Newman AH, Rice KC. σ Receptor negatively modulate agonist-stimulated phosphoinositide metabolism in rat brain. Eur J Pharmacol 1988, 149:399–400.

    Article  PubMed  CAS  Google Scholar 

  16. de Haven-Hudkins DL, Hudkins RL. Binding of dexetimide and levetimide to [3HI(+)-pentazocine and [3H]1,3Hdi(2-tolyl)guanidine-defined o recognition sites. Life Sci 1991, 49:PL135–PL139.

    Article  Google Scholar 

  17. Kobayashi T, Ikeda K, Ichikawa T, Togashi S, Kumanishi T. Effects of σ ligands on the cloned mu-, delta-and kappa-opioid receptors co-expressed with G-protein-activated Kf(GIRK) channel in Xenopus oocytes. Br J Pharmacol 1996, 119:73–80.

    PubMed  CAS  Google Scholar 

  18. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 1995, 52:998–1007.

    PubMed  CAS  Google Scholar 

  19. Tam SW. Potential therapeutic application of σ receptor antagonists. In Sigma Receptors. Y Itzhak, ed. Academic Press, San Diego, pp 191–204, 1994.

    Google Scholar 

  20. Su TP. Delineating biochemical and functional properties of a receptors: emerging concepts. Crit Rev Neurobiol 1993, 7: 187–203.

    PubMed  CAS  Google Scholar 

  21. Chavkin C. The o enigma: biochemical and functional correlates emerge for the haloperidol-sensitive σ binding site. Trends Neurosci 1990, 11:213–215.

    CAS  Google Scholar 

  22. Carpenter CL, Marks SS, Watson DL, Greenberg DA. Dextromethorphan and dextrorphan as calcium channel antagonists. Brain Res 1988, 449:372–375.

    Article  Google Scholar 

  23. Korkotian E, Segal M. Release of calcium from stores alters the morphology of dendritic spines in cultured hippocampal neurons. Proc Natl Acad Sci USA 1999, 96:12068–12072.

    Article  PubMed  CAS  Google Scholar 

  24. Ltischer C, Nicoll RA, Malenka RC, Muller M. Synaptic plasticity and dynamic modulation of the postsynaptic membrane. Nature Neurosci 2000, 3:545–550.

    Article  Google Scholar 

  25. Abel T, Lattal KM. Molecular mechanisms of memory acquisition, consolidation and retrieval. Curr Opinion Neurobiol2001, 11: 180–187.

    Article  CAS  Google Scholar 

  26. Palacios G, Muro A, Vela JM, Molina-Holgado E, Guitart X, Ovalle S, Zamanillo D. Immunohistochemical localization of the ol-receptor in oligodendrocytes in the rat central nervous system. Brain Res 2003, 96:92–99.

    Article  Google Scholar 

  27. Monnet FP, Mahk V, Robe1 P, Baulieu EE. Neurosteroids, via σ receptors, modulate the [3H]norepinephrine release evoked by NMDA in the rat hippocampus. Proc Natl Acad Sci USA 1995, 92:3774–3778.

    Article  PubMed  CAS  Google Scholar 

  28. Cammarota M, Bernabeu R, Levi De Stein M, Izquierdo I, Medina JH. Learningspecific, time-dependent increases in hippocampal Ca2+/calmodulin-dependent protein kinase I1 activity and AMPA GluRl subunit immunoreactivity. Eur J Neurosci 1998, 10:2669–76.

    Article  PubMed  CAS  Google Scholar 

  29. Maurice T, Su TP, Parish DW, Nabeshima T, Privat A. PRE-084, a selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. Pharmacol Biochem Behav 1994, 49239–869.

    Article  Google Scholar 

  30. Maurice T, Phan VL, Urani A, Kamei H, Noda Y, Nabeshima T. Neuroactive neurosteroids as endogeneous effectors for sigma-1 (oI) receptor: pharmacological evidence and therapeutic opportunities. Jpn J Pharmacol 1999, 81:125–155.

    Article  PubMed  CAS  Google Scholar 

  31. Matsumoto RR, Bowen W, Tom M, Vo V, Truong D, De Costa B. Characterization of two novel a receptor ligands: antidystonic effects in rats suggest σ receptor antagonism. Eur J Pharmacol 1995, 280:301–310.

    Article  PubMed  CAS  Google Scholar 

  32. Morin-Surun MP, Collin T, Denavit-Saubi C M, Baulieu EE, Monnet FP. Sigma-1 receptor modulate PLCIPKC cascade in the motor brainstem. Proc Natl Acad Sci USA 1999, 96:8196–8199.

    Article  PubMed  CAS  Google Scholar 

  33. Maurice T, Lockhart BP, Privat A. Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res 1996, 706: 181–193

    Article  PubMed  CAS  Google Scholar 

  34. Pande AC, GenBve J, Scherrer B. IgmCsine, a novel σ ligand, has antidepressant properties XXI CINP Abst 1998,30S–30M 0505.

    Google Scholar 

  35. Matsumoto RR, Bowen WD, Walker JM. Age-related differences in the sensitivity of rats to a selective σ ligand. Brain Res 1989, 504:145–148.

    Article  PubMed  CAS  Google Scholar 

  36. Hemstreet MK, Matsumoto RR, Bowen WD, Walker JM. Sigma binding parameters in developing rats predict behavioral efficacy of a σ ligand. Brain Res 1993, 627:291–198.

    Article  PubMed  CAS  Google Scholar 

  37. Hayashi T, Su TP. Regulating ankyrin dynamics: roles of a, receptors. Proc Natl Acad Sci USA 2001, 98:491–496.

    Article  PubMed  CAS  Google Scholar 

  38. Takebayashi M, Hayashi T, Su TP. Nerve growth factor-induced neurite sprouting in PC-12 cells involves σ1 receptors: implications for antidepressants. J Pharmacol Exp Ther 2002, 303: 1227–1237.

    Article  PubMed  CAS  Google Scholar 

  39. Vilner BJ, de Costa BJ, Bowen WD. Cytotoxic effects of σ ligands: σ receptor-mediated alterations in cellular morphology and variability. J Neurosci 1995, 15:117–134.

    PubMed  CAS  Google Scholar 

  40. Vilner BJ, John CS, Bowen WD. Sigma-1 and σ2 receptors are expressed in a wild variety of human and rodent tumor cell lines. Cancer Res 1995, 55:408–413.

    PubMed  CAS  Google Scholar 

  41. Vilner BJ, Bowen WD. Modulation of cellular calcium by σ2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. J Pharmacol Exp Ther 2000, 292:900–911.

    PubMed  CAS  Google Scholar 

  42. Itzhak Y, Khouri M. Regulation of the binding of σ-and phencyclidine(PCP)-receptor ligands in rat brain membranes by guanine nucleotides and ions. Neurosci Lett 1988, 85:147–152.

    Article  PubMed  CAS  Google Scholar 

  43. Monnet FP, Blier P, Debonnel G, de Montigny C. Modulation by σ ligands of N-methyl-D-aspartate-induced [3H]norepinephrine release in the rat hippocampus: G-protein dependency. Naunyn-Schmiedeberg Arch Pharmacol 1992a 346:32–39.

    Article  CAS  Google Scholar 

  44. Bowen WD. Interaction of σ receptors with signal transduction pathways and effects on second messengers, In Sigma Receptors. Y Itzhak, ed. Academic Press, San Diego, pp 139–170, 1994.

    Google Scholar 

  45. Monnet FP, Debonnel G, de Montigny C. In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by σ ligands. J Pharmacol Exp Ther 1992b, 261: 123–130.

    PubMed  CAS  Google Scholar 

  46. Lesage AS, De Loore KL, Peeters L, Leysen JE. Neuroprotective σ ligands interfere with the glutamate-activated NOS pathway in hippocampal cell culture. Synapse 1995, 20:156–164.

    Article  PubMed  CAS  Google Scholar 

  47. Hayashi T, Maurice T, Su TP. Ca2+ signaling via σ1 receptors: novel regulatory mechanism affecting intracellular Ca++ concentration. J Pharmacol Exp Ther 2000, 293:788–798.

    PubMed  CAS  Google Scholar 

  48. Ueda H, Yoshida A, Tokuyama S, Mizuno K, Maruo J, Matsuno K, Mita S. Neurosteroids stimulate G protein-coupled a receptors in mouse brain synaptic membrane. Neurosci Res 2001a, 41:33–40.

    Article  PubMed  CAS  Google Scholar 

  49. Ueda H, Inoue M, Yoshida A, Mizuno K, Yamamoto H, Maruo J, Matsuno K, Mita S. Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice. J Pharmacol Exp Ther 2001b, 298:703–710.

    PubMed  CAS  Google Scholar 

  50. Lupardus PJ, Wilke RA, Aydar E, Palmer CP, Chen Y, Ruoho AE, Jackson MB. Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol 2000, 526527–539.

    Article  PubMed  CAS  Google Scholar 

  51. Monnet FP, Debonnel G, de Montigny C. The effects of σ ligands and of neuropeptide Y on N-methyl-D-aspartate-induced neuronal activation are differentially affected by pertussis toxin in the rat CA3 dorsal hippocampus. Br J Pharmacol 1994, 112:709–715.

    PubMed  CAS  Google Scholar 

  52. Sommermeyer H, Dompert WU, Glaser T. Signalling via rat doparnine D2-receptors expressed in mouse fibroblasts is not influenced by compounds binding to the o sites of these cells. Cell Signal 1993, 5:747–752.

    Article  PubMed  CAS  Google Scholar 

  53. Soriani 0, LeFoll F, Roman F, Vaudry H, Monnet FP, Cazin L. A-current downregulated by σ ligands in frog pituitary melanotrope cells through a G-protein-dependent pathway. J Pharmacol Exp Ther 1999, 289:321–328.

    PubMed  CAS  Google Scholar 

  54. Klein M, Santiago LJ, Musacchio JM. Effect of calcium and other ion channel blocking agents on the high affinity binding of dextromethorphan to guinea pig brain. Soc Neurosci Abst 1985, 14236.

    Google Scholar 

  55. Rothman RB, Reid A, Mahboubi A, Kim CH, de Costa BJ, Jacobson AE, Rice KC. Labeling by [3H]1,3-di(2-tolyl)guanidine of two high affinity binding sites in guinea pig brain: evidence for allosteric regulation by calcium channel antagonists and pseudoallosteric modulation by σ ligands. Mol Pharmacol 1991, 39:222–232.

    PubMed  CAS  Google Scholar 

  56. Basile AS, Paul IA, Mirchevich A, Kuijpers G, de Costa BJ. Modulation of (+)[3H]pentazocine binding to guinea pig cerebellum by divalent ions. Mol Pharmacol 1992, 42:882–889.

    PubMed  CAS  Google Scholar 

  57. Kostyuk P, Akaike N, Osipchuk Y, Shvchenko A, Shuba Y. Gating and permeation of different types of Ca channels. Ann N Y Acad Sci 1989, 560:63–79.

    Article  PubMed  CAS  Google Scholar 

  58. Zhang H, Cuevas J. Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons. J Neurophysiol2002, 87:2867–79.

    PubMed  CAS  Google Scholar 

  59. Church J, Fletcher EJ. Blockade by σ site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurons. Br J Pharmacol 1995, 116:2801–2810.

    PubMed  CAS  Google Scholar 

  60. Paul IA, Basile AS, Rojas E, Youdim MBH, de Costa BJ, Skolnick P, Pollard HB, Kuijpers GAJ. Sigma receptors modulate nicotine receptor function in adrenal chromafin cells. FASEB J 1993, 7:1171–1178.

    PubMed  CAS  Google Scholar 

  61. Hayashi T, Kagaya A, Takebayashi M, Shimizu M, Uchitomi Y, Motohashi N, Yamawaki S. Modulation by sigma ligands of intracellular free CaZ+ mobilization by N-methyl-D-aspartate in primary culture of rat frontal cortical neurons. J Pharmacol Exp Ther 1995, 275:207–214.

    PubMed  CAS  Google Scholar 

  62. Klette KL, Lin Y, Clapp LE, de Coster MA, Moreton JE, Tortella FC. Neuroprotective sigma ligands attenuate NMDA and trans-ACPD-induced Ca signaling in rat primary neurons. Brain Res 1997, 756:231–240.

    Article  PubMed  CAS  Google Scholar 

  63. Monnet FP, de Costa BR, Bowen WD. Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]noradrenaline release in rat hippocampal slices. Br J Pharmacol 1996, 119:65–72.

    PubMed  CAS  Google Scholar 

  64. Brent PJ, Pang G, Little G, Dosen PJ, van Helden DF. The σ receptor ligand, reduced haloperidol, induces apoptosis and increases intracellular-free Ca levels [Ca+]i in colon and mammary adenocarcinoma cells. Biochem Biophys Res Commun 1996, 219:219–226.

    Article  PubMed  CAS  Google Scholar 

  65. Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR. Protein phosphorylation and Ca uptake into rat forebrain synaptosomes: modulation by σ ligands. J Neurochem 1997, 68:2201–2211.

    Article  PubMed  CAS  Google Scholar 

  66. Novakova M, Ela C, Bowen WD, Hasin Y, Eilam Y. Highly selective a receptor ligands elevate inositol 1,4,5-triphosphate production in rat cardiac myocytes. Eur J Pharmacol 1998, 353:315–327.

    Article  PubMed  CAS  Google Scholar 

  67. Monnet FP, Morin-Surun MP, Leger J, Combettes L. Protein kinase C-dependent potentiation of intracellular Ca mobilization by σ1 receptor agonists in rat hippocampal neurons. J. Pharmacol Exp Ther 2003, 307:705–712.

    Article  PubMed  CAS  Google Scholar 

  68. Novakova M, Ela C, Barg J, Vogel Z, Hasin Y, Eilam Y. Ionotropic action of σ receptor ligands in isolated cardiac myocytes from adult rats. Eur J Pharmacol 1995, 286:19–30.

    Article  PubMed  CAS  Google Scholar 

  69. Aydar E, Palmer CP, Klyachko VA, Jackson MB. The a receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 2002, 34:399–410.

    Article  PubMed  CAS  Google Scholar 

  70. Candura SM, Coccini T, Manzo L, Costa LG. Interaction of o-compounds with receptorstimulated phosphoinositide metabolism in the rat brain. J Neurochem 1990, 55:1741–1748.

    Article  PubMed  CAS  Google Scholar 

  71. Monnet FP, Morin-Surun MP. Electrophysiological evidence for the role of protein kinase C in the action of σ1 receptor ligands. Soc Neurosci Abst 1997, 23:905.5.

    Google Scholar 

  72. Brent PJ, Haynes H, Jarvie PE, Mudge L, Sim AT, Dunkley PR. Phosphorylation of synapsin I and dynamin in rat forebrain synaptosomes: modulation by sigma (o) ligands. Neurosci Lett 1995, 1-2:71–74.

    Article  Google Scholar 

  73. Matsumoto RR, Walker JM. Inhibition of rubral neurons by a specific ligand for σ receptors. Eur J Pharmacol 1988, 158:161–165.

    Article  PubMed  CAS  Google Scholar 

  74. Tanaka C, Nishizuka Y. The protein kinase C family for neuronal signaling. Ann Rev Neurosci 1994, 17:551–567.

    Article  PubMed  CAS  Google Scholar 

  75. Newton AC. Protein kinase C: structure, function, and regulation. J Biol Chem 1995, 270:28495–28498.

    Article  PubMed  CAS  Google Scholar 

  76. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, Duhamel L, Charon D, Kirilovsky J. J Biol Chem 1991, 266:15771–15781.

    PubMed  CAS  Google Scholar 

  77. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D, Schachtele C. Selective inhibition of protein kinase C isozymes by the indolocarbazole Go-6976. J Biol Chem 1993, 268:9194–9197.

    PubMed  CAS  Google Scholar 

  78. McCann DJ, Su TP. Solubilization and characterization of haloperidol-sensitive (+)-[3H]-SKF 10,047 binding sites (o sites) from rat liver membranes. J Pharmacol Exp Ther 1991, 257:547–554.

    PubMed  CAS  Google Scholar 

  79. Klouz A, Sapena R, Liu J, Maurice T, Tillement JP, Papadopoulos V, Morin D. Evidence for 0,-like receptors in isolated rat liver mitochondria1 membranes. Br J Pharmacol2002, 135: 1607–1615.

    Article  PubMed  CAS  Google Scholar 

  80. Cheung WM, Chu AH, Chu PW, Ip NY. Cloning and expression of a novel nuclear matrix-associated protein that is regulated during the retinoic acid-induced neuronal differentiation. J Biol Chem 2001, 276: 17083–17091.

    Article  PubMed  CAS  Google Scholar 

  81. Nuwayhid SJ, Werling LL. Sigma-1 receptor agonist-mediated regulation of N-methyl-D-aspartate-stimulated [3H]dopamine release is dependent upon protein kinase C. J Pharmacol Exp Ther 2003, 304:364–369.

    Article  PubMed  CAS  Google Scholar 

  82. Ela C, Hasin Y, Eilam Y. Apparent desensitization of a σ receptor subpopulation in neonatal rat cardiac myocytes by pre-treatment with σ receptor ligands. Eur J Pharmacol 1996.295:275–280.

    Article  PubMed  CAS  Google Scholar 

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Monnet, F.P. (2007). Intracellular Signaling and Synaptic Plasticity. In: Su, TP., Matsumoto, R.R., Bowen, W.D. (eds) Sigma Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36514-5_9

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