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Co-stimulation Regulation of Immune Tolerance and Autoimmunity

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Immune Regulation and Immunotherapy in Autoimmune Disease

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References

  • Agata, Y., Kawasaki, A., Nishimura, H., et al. (1996) Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8(5):765–772.

    Article  PubMed  CAS  Google Scholar 

  • Akbari, O., Freeman, G. J., Meyer, et al. (2002) Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8(9):1024–1032.

    Article  PubMed  CAS  Google Scholar 

  • Akiba, H., Takeda, K., Kojima, Y., et al. (2005) The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo. J. Immunol. 175(4):2340–2348.

    PubMed  CAS  Google Scholar 

  • Ansari, M. J., Abdi, R. (2003) Emerging immunomodulatory therapies targeting the co-stimulatory pathways for the prevention of transplant rejection. Drugs 6(10):964–969.

    CAS  Google Scholar 

  • Brown, J. A., Dorfman, D. M., Ma, F. R., et al. (2003) Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170(3):1257–1266.

    PubMed  CAS  Google Scholar 

  • Chabaud, M., Durand, J. M., Buchs, N., et al. (1999) Human interleukin-17: A T cell-derived proinflammatory cytokine produced by the rheumatoid synovium. Arthritis Rheum. 42:963–970.

    Article  PubMed  CAS  Google Scholar 

  • Chambers, C. A., Allison, J. P. (1999) Costimulatory regulation of T cell function. Curr. Opin. Cell Biol. 11(2):203–210.

    Article  PubMed  CAS  Google Scholar 

  • Chapoval, A. I., Ni, J., Lau, J. S., et al. (2001) B7–H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3):269–274.

    Article  PubMed  CAS  Google Scholar 

  • Chen, Y., Li, J., Zhang, J., et al. (2005) Sinomenine inhibits B7–H1 and B7-DC expression on human renal tubular epithelial cells. Int. Immunopharmaco., 5(9):1446–1457.

    Article  CAS  Google Scholar 

  • De Haij, S., Woltman, A. M., Trouw, L. A., et al. (2005) Renal tubular epithelial cells modulate T-cell responses via ICOS-L and B7–H1. Kidney Int. 68(5):2091–2102.

    Article  PubMed  Google Scholar 

  • Dong, C., Flavell, R. A. (2000a) Cell fate decision: T-helper 1 and 2 subsets in immune responses. Arthritis Res. 2(3):179–188.

    Article  PubMed  CAS  Google Scholar 

  • Dong, C., Flavell, R. A. (2000b) Control of T helper cell differentiation—in search of master genes. Sci STKE 2000(49):E1.

    Article  Google Scholar 

  • Dong, C., Juedes, A. E., Temann, U. A., et al. (2001a). ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409(6816):97–101.

    Article  PubMed  CAS  Google Scholar 

  • Dong, C., Nurieva, R. I. (2003). Regulation of immune and autoimmune responses by ICOS. J/ Autoimmun. 21(3):255–260.

    Article  Google Scholar 

  • Dong, C., Temann, U. A., Flavell, R. A. (2001b) Cutting edge: critical role of inducible costimulator in germinal center reactions. J. Immunol. 166(6):3659–3662.

    PubMed  CAS  Google Scholar 

  • Dong, H., Chen, L. (2003) B7–H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 81(5):281–287.

    PubMed  CAS  Google Scholar 

  • Dong, H., Zhu, G., Tamada, K., Chen, L. (1999) B7–H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5(12):1365–1369.

    Article  PubMed  CAS  Google Scholar 

  • Dong, H., Zhu, G., Tamada, K., et al. (2004) B7–H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity 20(3):327–336.

    Article  PubMed  CAS  Google Scholar 

  • Faria, A. M., Maron, R., Ficker. S. M., et al. (2003) Oral tolerance induced by continuous feeding: enhanced up-regulation of transforming growth factor-beta/interleukin-10 and suppression of experimental autoimmune encephalomyelitis. J. Autoimmun. 20:135–145.

    Article  PubMed  CAS  Google Scholar 

  • Finger, L. R., Pu, J., Wasserman, R., et al. (1997). The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in B cell progenitors. Gene 197(1–2):177–187.

    Article  PubMed  CAS  Google Scholar 

  • Fossiez, F., Djossou, O., Chomarat, P., et al. (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183:2593–2603.

    Article  PubMed  CAS  Google Scholar 

  • Fontenot, J. D., Rudensky, A. Y. (2005) A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3. Nat. Immunol. 6(4):331–337.

    Article  PubMed  CAS  Google Scholar 

  • Freeman, G. J., Long, A. J., Iwai, Y., et al. (2000) Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192(7):1027–1034.

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez, L. C., Loyet, K. M., Calemine-Fenaux, J., et al. (2005) A coreceptor interaction between the CD28 and TNF receptor family members B and T lymphocyte attenuator and herpesvirus entry mediator 10.1073/pnas.0409071102. Proc. Natl. Acad. Sci. U S A 102(4):1116–1121.

    Article  PubMed  CAS  Google Scholar 

  • Greenwald, R. J., Freeman, G. J., Sharpe, A. H. (2005) The B7 family revisited. Annu. Rev. Immunol. 23(1);515–548.

    Article  PubMed  Google Scholar 

  • Grimbacher, B., Hutloff, A., Schlesier, M., et al. (2003) Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nat. Immunol. 4(3):261–268.

    Article  PubMed  CAS  Google Scholar 

  • Harrington, L. E., Hatton, R. D., Mangan, P. R., et al. (2005) Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6(11):1123–1132.

    Article  PubMed  CAS  Google Scholar 

  • Heath, W. R., Carbone, F. R. (2001) Cross-presentation, dendritic cells, tolerance and immunity. Annu. Rev. Immunol. 19:47–64.

    Article  PubMed  CAS  Google Scholar 

  • Herman, A. E., Freeman, G. J., Mathis, D., Benoist, C. (2004) CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesion. J. Exp. Med. 199(11):1479–1489.

    Article  PubMed  CAS  Google Scholar 

  • Ho, I. C., Lo, D., Glimcher, L. H. (1998). c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 188(10):1859–1866.

    Article  PubMed  CAS  Google Scholar 

  • Hurchla, M. A., Sedy, J. R., Gavrielli, M., et al. (2005) B and T lymphocyte attenuator exhibits structural and expression polymorphisms and is highly induced in anergic CD4+ T cells J. Immunol. 174(6):3377–3385.

    PubMed  CAS  Google Scholar 

  • Hutloff, A., Dittrich, A. M., Beier, K. C., et al. (1999) ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397:263–266.

    Article  PubMed  CAS  Google Scholar 

  • Ishida, Y., Agata, Y., Shibahara, K., Honjo, T. (1992) Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11(11):3887–3895.

    PubMed  CAS  Google Scholar 

  • Iwai, H., Abe, M., Hirose, S., et al. (2003) Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J. Immunol. 171(6):2848–2854.

    PubMed  CAS  Google Scholar 

  • Iwai, H., Kozono, Y., Hirose, S., et al. (2002) Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. J. Immunol. 169(8):4332–4339.

    PubMed  CAS  Google Scholar 

  • Janeway, C. A., Jr., Medzhitov, R. (2002) Innate immune recognition. Annu. Rev. Immunol. 20:197–216.

    Article  PubMed  CAS  Google Scholar 

  • Kanai, T., Totsuka, T., Uraushihara, K., et al. (2003) Blockade of B7–H1 suppresses the development of chronic intestinal inflammation. J. Immunol. 171(8):4156–4163.

    PubMed  CAS  Google Scholar 

  • Kim, J. I., Ho, I. C., Grusby, M. J., Glimcher, L. H. (1999) The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokines. Immunity 10:745–751.

    Article  PubMed  CAS  Google Scholar 

  • Krieg, C., Han, P., Stone, R., et al. (2005) Functional analysis of B and T lympho-cyte attenuator engagement on CD4+ and CD8+ T cells J. Immunol, 175(10):6420–6427.

    PubMed  CAS  Google Scholar 

  • Kroner, A., Mehling, M., Hemmer, B., et al. (2005) A PD-1 polymorphism is associated with disease progression in multiple sclerosis. Ann. Neurol. 58(1):50–57.

    Article  PubMed  CAS  Google Scholar 

  • Langrish, C. L., Chen, Y., Blumenschein, W. M., et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201(2):233–240.

    Article  PubMed  CAS  Google Scholar 

  • Latchman, Y., Wood, C. R., Chernova, T., et al. (2001) PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2(3):261–268.

    Article  PubMed  CAS  Google Scholar 

  • Latchman, Y. E., Liang, S. C., Wu, Y., et al. (2004) PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells 10.1073/pnas.0307252101. Proc. Natl. Acad. Sci. U S A 101(29):10691–10696.

    Article  PubMed  CAS  Google Scholar 

  • Leonard, W. J., Spolski, R. (2005) Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat. Rev. Immunol. 5(9):688–698.

    Article  PubMed  CAS  Google Scholar 

  • Liang, S. C., Latchman, Y. E., Buhlmann, J. E., et al. (2003) Regulation of PD-1, PD-L1, and PD-L2 expression during normal and autoimmune responses. Eur. J. Immunol. 33(10):2706–2716.

    Article  PubMed  CAS  Google Scholar 

  • Lohning, M., Hutloff, A., Kallinich, T., et al. (2003) Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197(2):181–193.

    Article  PubMed  CAS  Google Scholar 

  • Loke, P., Allison, J. P. (2003) PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells. Proc. Natl. Acad. Sci. U S A 100(9):5336–5341.

    Article  PubMed  CAS  Google Scholar 

  • Lubberts, E., Joosten, L. A., Oppers, B., et al. (2001) IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis. J. Immunol. 167(2):1004–1013.

    PubMed  CAS  Google Scholar 

  • Lubberts, E., Joosten, L. A., van de Loo, F. A., et al. (2002) Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction. Inflamm. Res. 51(2):102–104.

    Article  PubMed  CAS  Google Scholar 

  • Mak, T. W., Shahinian, A., Yoshinaga, S. K., et al. (2003) Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nat. Immunol. 4(8):765–772.

    Article  PubMed  CAS  Google Scholar 

  • Massey, E. J., Sundstedt, A., Day, M. J., et al. (2002) Intranasal peptide-induced peripheral tolerance: the role of IL-10 in regulatory T cell function within the context of experimental autoimmune encephalomyelitis. Vet. Immunol. Immunopathol. 87(3–4): 357–372.

    Article  PubMed  CAS  Google Scholar 

  • Mazanet, M. M., Hughes, C. C. (2002) B7–H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 169(7):3581–3588.

    PubMed  CAS  Google Scholar 

  • McAdam, A. J., Greenwald, R. J., Levin, M. A., et al. (2001) ICOS is critical for CD40-mediated antibody class switching. Nature 409:102–105.

    Article  PubMed  CAS  Google Scholar 

  • Miyamoto, K., Kingsley, C. I., Zhang, X., et al. (2005) The ICOS molecule plays a crucial role in the development of mucosal tolerance. J. Immunol. 175(11):7341–7347.

    PubMed  CAS  Google Scholar 

  • Mueller, D. L., Jenkins, M. K., Schwartz, R. H. (1989) Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7:445–480.

    PubMed  CAS  Google Scholar 

  • Nielsen, C., Hansen, D., Husby, S., et al. (2003) Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes. Tissue Antigens 62(6):492–497.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura, H., Nose, M., Hiai, H., et al. (1999) Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11(2):141–151.

    Article  PubMed  CAS  Google Scholar 

  • Nishimura, H., Okazaki, T., Tanaka, Y., et al. (2001) Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291(5502):319–322.

    Article  PubMed  CAS  Google Scholar 

  • Nurieva, R. I. (2005) Regulation of immune and autoimmune responses by ICOS-B7h interaction. Clin. Immunol. 115(1):19–25.

    Article  PubMed  CAS  Google Scholar 

  • Nurieva, R. I., Duong, J., Kishikawa, H., et al. (2003a) Transcriptional regulation of th2 differentiation by inducible costimulator. Immunity 18(6):801–811.

    Article  PubMed  CAS  Google Scholar 

  • Nurieva, R. I., Mai, X. M., Forbush, K., et al. (2003b) B7h is required for T cell activation, differentiation, and effector function. Proc. Natl. Acad. Sci. U S A 100(24): 14163–14168.

    Article  PubMed  CAS  Google Scholar 

  • Okazaki, T., Maeda, A., Nishimura, H., et al. (2001) PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. U S A 98(24):13866–13871.

    Article  PubMed  CAS  Google Scholar 

  • Okazaki, T., Otaka, Y., Wang, J., et al. (2005) Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB/c-Fcgr2b-/-Pdcd1-/- mice. J Exp Med 202(12):1643–1648.

    Article  PubMed  CAS  Google Scholar 

  • Okazaki, T., Tanaka, Y., Nishio, R., et al. (2003) Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice. Nat. Med. 9(12):1477–1483.

    Article  PubMed  CAS  Google Scholar 

  • Ozaki, K., Spolski, R., Ettinger, R., et al. (2004) Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173:5361–5371.

    PubMed  CAS  Google Scholar 

  • Park, H., Li, Z., Yang, X. O., et al. (2005) A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6(11):1133–1141.

    Article  PubMed  CAS  Google Scholar 

  • Petroff, M. G., Chen, L., Phillips, T. A., Hunt, J. S. (2002) B7 family molecules: novel immunomodulators at the maternal-fetal interface. Placenta 23(Suppl A):S95–S101.

    Article  PubMed  Google Scholar 

  • Prasad, D. V., Richards, S., Mai, X. M., Dong, C. (2003) B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18(6):863–873.

    Article  PubMed  CAS  Google Scholar 

  • Prasad, D. V. R., Nguyen, T., Li, Z., et al. (2004) Mouse B7–H3 is a negative regulator of T cells. J. Immunol. 173:2500–2506.

    PubMed  CAS  Google Scholar 

  • Prokunina, L., Castillejo-Lopez, C., Oberg, F., et al. (2002) A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat. Genet. 32(4):666–669.

    Article  PubMed  CAS  Google Scholar 

  • Prokunina, L., Padyukov, L., Bennet, A., et al. (2004) Association of the PD-1.3A allele of the PDCD1 gene in patients with rheumatoid arthritis negative for rheumatoid factor and the shared epitope. Arthritis Rheum. 50(6):1770–1773.

    Article  PubMed  CAS  Google Scholar 

  • Rottman, J. B., Smith, T., Tonra, J. R., et al. (2001) The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE. Nat. Immunol. 2(7), 605–611.

    Article  PubMed  CAS  Google Scholar 

  • Salama, A. D., Chitnis, T., Imitola, J., et al. (2003) Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 198(1):71–78.

    Article  PubMed  CAS  Google Scholar 

  • Schwartz, R. H. (2003) T cell anergy. Annu. Rev. Immunol. 21:305–334.

    Article  PubMed  CAS  Google Scholar 

  • Sedy, J. R., Gavrieli, M., Potter, K. G., et al. (2005) B and T lymphocyte attenuator regulates T cell activation through interaction with herpesvirus entry mediator. Nat. Immunol. 6(1):90–98.

    Article  PubMed  CAS  Google Scholar 

  • Shinohara, T., Taniwaki, M., Ishida, Y., et al. (1994) Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics 23(3):704–706.

    Article  PubMed  CAS  Google Scholar 

  • Sica, G. L., Choi, I. H., Zhu, G., et al. (2003) B7–H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 18(6):849–861.

    Article  PubMed  CAS  Google Scholar 

  • Steinman, R. M., Hawiger, D., Nussenzweig, M. C. (2003) Tolerogenic dendritic cells. Annu. Rev. Immunol. 21(1):685–711.

    Article  PubMed  CAS  Google Scholar 

  • Subudhi, S. K., Zhou, P., Yerian, L. M., et al. (2004) Local expression of B7–H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113(5):694–700.

    PubMed  CAS  Google Scholar 

  • Suh, W. K., Gajewska, B. U., Okada, H., et al. (2003) The B7 family member B7–H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 4(9):899–906.

    Article  PubMed  CAS  Google Scholar 

  • Suh, W-K., Tafuri, A., Berg-Brown, N. N., et al. (2004) The inducible constimulator plays the major costimulatory role in humoral immune responses in the absence of CD28. J. Immunol. 172(10): 5917–5923.

    PubMed  CAS  Google Scholar 

  • Sun, M., Richards, S., Prasad, D. V., et al. (2002) Characterization of mouse and human B7–H3 genes. J. Immunol. 168(12):6294–6297.

    PubMed  CAS  Google Scholar 

  • Swallow, M. M., Wallin, J. J., Sha, W. C. (1999) B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFa. Immunity 11:423–432.

    Article  PubMed  CAS  Google Scholar 

  • Tafuri, A., Shahinian, A., Bladt, F., et al. (2001) ICOS is essential for effective T-helper-cell responses. Nature 2001(409):105–109.

    Article  Google Scholar 

  • Tiegs, G., Hentschel, J., Wendel, A. (1992) A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90(1):196–203.

    Article  PubMed  CAS  Google Scholar 

  • Totsuka, T., Kanai, T., Makita, S., et al. (2005) Regulation of murine chronic colitis by CD4+CD25-programmed death-1+T cells. Eur. J. Immunol. 35(6):1773–1785.

    Article  PubMed  CAS  Google Scholar 

  • Tseng, S. Y., Otsuji, M., Gorski, K., et al. (2001) B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193(7):839–846.

    Article  PubMed  CAS  Google Scholar 

  • Vinuesa, C. G., Cook, M. C., Angelucci, C., et al. (2005a) A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 435(7041):452–458.

    Article  PubMed  CAS  Google Scholar 

  • Vinuesa, C. G., Tangye, S. G., Moser, B., Mackay, C. R. (2005b) Follicular B helper T cells in antibody responses and autoimmunity. Nat. Rev. Immunol. 5(11):853–865.

    Article  PubMed  CAS  Google Scholar 

  • Wang, J., Yoshida, T., Nakaki, F., et al. (2005) Establishment of NOD-Pdcd1-/- mice as an efficient animal model of type I diabetes. Proc. Natl. Acad. in U S A, 102(33): 11823–11828.

    Article  CAS  Google Scholar 

  • Watanabe, N., Gavrieli, M., Sedy, J. R., et al. (2003) BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 4(7): 670–679.

    Article  PubMed  CAS  Google Scholar 

  • Wong, S. C., Oh, E., Ng, C. H., Lam, K. P. (2003) Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7–H2. Blood 102(4):1381–1388.

    Article  PubMed  CAS  Google Scholar 

  • Yamazaki, T., Akiba, H., Iwai, H., et al. (2002) Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169(10):5538–5545.

    PubMed  CAS  Google Scholar 

  • Yao, Z., Painter, S. L., Fanslow, W. C., et al. (1995) Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155(12):5483–5486.

    PubMed  CAS  Google Scholar 

  • Yoshinaga, S. K., Whoriskey, J. S., Khare, S. D., et al. (1999) T-cell co-stimulation through B7RP-1 and ICOS. Nature 402(6763):827–832.

    Article  PubMed  CAS  Google Scholar 

  • Zang, X., Loke, P., Kim, J., et al. (2003) B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. U S A, 100(18):10388–10392.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Immunology, MD Anderson Cancer Centre, Houston, TX, USA

    Chen Dong, Roza Nurieva & Natalia Martin-Orozco

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  1. Chen Dong
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  1. Shanghai JiaoTong University School of Medicine, Shanghai, China

    Jingwu Zhang M.D., Ph.D.

  2. Baylor College of Medicine, Houston, Texas, USA

    Jingwu Zhang M.D., Ph.D.

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Dong, C., Nurieva, R., Martin-Orozco, N. (2007). Co-stimulation Regulation of Immune Tolerance and Autoimmunity. In: Zhang, J. (eds) Immune Regulation and Immunotherapy in Autoimmune Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36003-4_7

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