Skip to main content

Nonmyeloablative Stem Cell Transplantation for Multiple Sclerosis

  • Chapter
Immune Regulation and Immunotherapy in Autoimmune Disease

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alvarez-Dolado, M., Pardal, R., Garcia-Verdugo, J. M., et al. (2003) Fusion of bone marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425:968–973.

    Article  PubMed  CAS  Google Scholar 

  • Ben-Hur, T., Einstein, O., Mizrachi-Kol, R., et al. (2003) Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis. Glia 41:73–80.

    Article  PubMed  Google Scholar 

  • Bjorklund, L. M., Sanchez-Pernaute, R., Chung, S., et al. (2002) Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc. Natl. Acad. Sci. USA 99:2344–2349.

    Article  PubMed  CAS  Google Scholar 

  • Burt, R. K., Burns, W., Hess, A. (1995) Bone marrow transplantation for multiple sclerosis. Bone Marrow Transplant. 16:1–6.

    PubMed  CAS  Google Scholar 

  • Burt, R. K., Padilla, J., Begolka, W. S., et al. (1998) Effect of disease stage on clinical outcome after syngeneic bone marrow transplantation for relapsing experimental autoimmune encephalomyelitis. Blood 91:2609–2616.

    PubMed  CAS  Google Scholar 

  • Burt, R. K., Cohen, B. A., Russell, E., et al. (2003) Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores. Blood 102:2373–2378.

    Article  PubMed  CAS  Google Scholar 

  • Burt, R. K., Oyama, Y., Verda, L., et al. (2004a) Induction of remission of severe and refractory rheumatoid arthritis by allogeneic mixed chimerism. Arthritis Rheum. 50:2466–2470.

    Article  PubMed  Google Scholar 

  • Burt, R. K., Verda, L., Kim, D. A., et al. (2004b) Embryonic stem cells as an alternate marrow donor source: engraftment without graft-versus-host disease. J. Exp. Med. 199:895–904.

    Article  PubMed  CAS  Google Scholar 

  • Carpenter, M. K., Rosler, E., Rao, M. S. (2003) Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells 5:79–88.

    Article  PubMed  CAS  Google Scholar 

  • Di Nicola, M., Carlo-Stella, C., Magni, M., Milanesi, M., et al. (2002) Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838–3843.

    Article  PubMed  Google Scholar 

  • Edwards, R. G. (1987) In vitro fertilization: past and future. Ann. Biol. Clin. 45:321–329.

    CAS  Google Scholar 

  • Edwards, R. G. (2004) Stem cells today. A. Origin and potential of embryo stem cells. Reprod. Biomed. Online 8:275–306.

    Article  PubMed  CAS  Google Scholar 

  • Eglitis, M. A., Mezey, E. (1997) Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice. Proc. Natl. Acad. Sci. USA 94:4080–4085.

    Article  PubMed  CAS  Google Scholar 

  • Fassas, A., Anagnostopoulos, A., Kazis, A., et al. (2000) Autologous stem cell transplantation in progressive multiple sclerosis—an interim analysis of efficacy. J. Clin. Immunol. 20:24–30.

    Article  PubMed  CAS  Google Scholar 

  • Fassas, A., Passweg, J. R., Anagnostopoulos, A., et al. (2002) Hematopoietic stem cell transplantation for multiple sclerosis: a retrospective multicenter study. J. Neurol. 249:1088–1097.

    Article  PubMed  CAS  Google Scholar 

  • Inglese, M., Mancardi, G. L., Pagani, E., et al. (2004) Brain tissue loss occurs after suppression of enhancement in patients with multiple sclerosis treated with autologous haematopoietic stem cell transplantation. J. Neurol. Neurosurg. Psychiatry 75:643–644.

    PubMed  CAS  Google Scholar 

  • Inoue, M., Honmou, O., Oka, S., et al. (2003) Comparative analysis of remyelinating potential of focal and intravenous administration of autologous bone marrow cells into the rat demyelinated spinal cord. Glia 44:111–118.

    Article  PubMed  Google Scholar 

  • Johnson, J., Bagley, J., Skaznik-Wikiel, M., et al. (2005) Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood. Cell 122:303–315.

    Article  PubMed  CAS  Google Scholar 

  • Karussis, D. M., Slavin, S., Lehmann, D., et al. (1992) Prevention of experimental autoimmune encephalomyelitis and induction of tolerance with acute immunosuppression followed by syngeneic bone marrow transplantation. J. Immunol. 148:1693–1698.

    PubMed  CAS  Google Scholar 

  • Karussis, D. M., Vourka-Karussis, U., Lehmann, D., et al. (1993) Prevention and reversal of adoptively transferred, chronic relapsing experimental autoimmune encephalomyelitis with a single high-dose cytoreductive treatment followed by syngeneic bone marrow transplantation. J. Clin. Invest. 92:765–772.

    Article  PubMed  CAS  Google Scholar 

  • Kozak, T., Havrdova, E., Pit’ha, J., et al. (2001) Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis. Transplant. Proc. 33:2179–2181.

    Article  PubMed  CAS  Google Scholar 

  • Krause, D. S., Theise, N. D., Collector, M. I., et al. (2001) Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369–377.

    Article  PubMed  CAS  Google Scholar 

  • Le Blanc, K., Rasmusson, I., Sundberg, B., et al. (2004) Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal cells. Lancet 363:1439–1441.

    Article  PubMed  Google Scholar 

  • Mancardi, G. L., Saccardi, R., Filippi, M., et al. (2001) Autologous hematopoietic stem cell transplantation suppresses Gd enhanced MRI activity in MS. Neurology 57:62–68.

    PubMed  CAS  Google Scholar 

  • Mancardi, G., Saccardi, R., Murialdo, A., et al. (2004) Intense immunosuppression followed by autologous stem cell transplantation in severe multiple sclerosis cases: MRI and clinical data. In: Burt, R. K., Marmont, A. (eds) Stem Cell Therapy for Autoimmune Diseases. Landes Bioscience, Georgetown, pp 302–307.

    Google Scholar 

  • McDonald, J. W., Liu, X. Z., Qu, Y., et al. (1999) Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat. Med. 5:1410–1412.

    Article  PubMed  CAS  Google Scholar 

  • Mezey, E., Key, S., Vogelsang, G., et al. (2003) Transplanted bone marrow generates new neurons in human brains. Proc. Natl. Acad. Sci. USA 100:1364–1369.

    Article  PubMed  CAS  Google Scholar 

  • Monje, M. L., Mizumatsu, S., Fike, J. R., Palmer, T. D. (2002) Irradiation induces neural precursor-cell dysfunction. Nat. Med. 8:955–962.

    Article  PubMed  CAS  Google Scholar 

  • Muraro, P. A., Douek, D. C., Packer, A., et al. (2005) Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J. Exp. Med. 201:805–816.

    Article  PubMed  CAS  Google Scholar 

  • Nash, R. A., Bowen, J. D., McSweeney, P. A., et al. (2003) High-dose immunosuppressive therapy and autologous peripheral blood stem cell transplantation for severe multiple sclerosis. Blood 102:2364–2372.

    Article  PubMed  CAS  Google Scholar 

  • Nunes, M. C., Roy, N. S., Keyoung, H. M., et al. (2003) Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain. Nat. Med. 9:439–447.

    Article  PubMed  CAS  Google Scholar 

  • Openshaw, H., Lund, B. T., Kashyap, A., et al. (2000) Peripheral blood stem cell transplantation in multiple sclerosis with busulfan and cyclophosphamide conditioning: report of toxicity and immunological monitoring. Biol. Blood Marrow Transplant. 6:563–575.

    Article  PubMed  CAS  Google Scholar 

  • Pluchino, S., Quattrini, A., Brambilla, E., et al. (2003) Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422:688–694.

    Article  PubMed  CAS  Google Scholar 

  • PRISMS Study Group. (1998) Randomised, double-blind, placebo-controlled study of interferon-beta 1a in relapsing-remitting multiple sclerosis. Lancet 352:1498–1504.

    Article  Google Scholar 

  • Reubinoff, B. E., Itsykson, P., Turetsky, T., et al. (2001) Neural progenitors from human embryonic stem cells. Nat. Biotechnol. 19:1134–1140.

    Article  PubMed  CAS  Google Scholar 

  • Saccardi, R., Mancardi, G. L., Solari, A., et al. (2005) Autologous HSCT for severe progressive multiple sclerosis in a multicenter trial: impact on disease activity and quality of life. Blood 105:2601–2607.

    Article  PubMed  CAS  Google Scholar 

  • Saiz, A., Carreras, E., Berenguer, J., et al. (2001) MRI and CSF oligoclonal bands after autologous hematopoietic stem cell transplantation in MS. Neurology 56:1084–1089.

    PubMed  CAS  Google Scholar 

  • Saiz, A., Blanco, Y., Carreras, E., et al. (2004) Clinical and MRI outcome after autologous hematopoietic stem cell transplantation in MS. Neurology 62:282–284.

    PubMed  CAS  Google Scholar 

  • Samijn, J. P., te Boekhorst, P. A., Mondria, T., et al. (2006) Intense T cell depletion followed by autologous bone marrow transplantation for severe multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 77:46–50.

    Article  PubMed  CAS  Google Scholar 

  • Thompson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., et al. (1998) Embryonic stem cell lines derived from human blastocysts. Science 283:1145–1147.

    Article  Google Scholar 

  • Van Gelder, M., van Bekkum, D. W. (1996a) Effective treatment of relapsing experimental autoimmune encephalomyelitis with pseudoautologous bone marrow transplantation. Bone Marrow Transplant. 18:1029–1034.

    PubMed  Google Scholar 

  • Van Gelder, M., Mulder, A. H., van Bekkum, D. W. (1996b) Treatment of relapsing experimental autoimmune encephalomyelitis with largely MHC-mismatched allogeneic bone marrow transplantation. Transplantation 62:810–818.

    Article  PubMed  Google Scholar 

  • Wagers, A. J., Sherwood, R. I., Christensen, J. L., Weissman, I. L. (2002) Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297:2256–2259.

    Article  PubMed  CAS  Google Scholar 

  • Wobus, A. M., Holzhausen, H., Jakel, P., Schoneich, J. (1984) Characterization of a pluripotent stem cell line derived from a mouse embryo. Exp. Cell. Res. 152:212–219.

    Article  PubMed  CAS  Google Scholar 

  • Xian, H. Q., McNichols, E., St. Clair, A., Gottlieb, D. I. (2003) A subset of ES-cell-derived neural cells marked by gene targeting. Stem Cells 21:41–49.

    Article  PubMed  CAS  Google Scholar 

  • Zappia, E., Casazza, S., Pedemonte, E., et al. (2005) Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 106:1755–1761.

    Article  PubMed  CAS  Google Scholar 

  • Zhang, S. C., Wernig, M., Duncan, I. D., et al. (2001) In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat. Biotechnol. 19:1129–1133.

    Article  PubMed  CAS  Google Scholar 

  • Zhao, R. C., Liao, L., Han, Q. (2003) Mechanisms of and perspectives on the mesenchymal stem cells in immunotherapy. J. Lab. Clin. Med. 143:284–291.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Burt, R.K., Loh, Y., Verda, L. (2007). Nonmyeloablative Stem Cell Transplantation for Multiple Sclerosis. In: Zhang, J. (eds) Immune Regulation and Immunotherapy in Autoimmune Disease. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-36003-4_17

Download citation

Publish with us

Policies and ethics