Abstract
XNBC is software to model and simulate biological neural networks. Four models of neurons are available: a phenomenological model, a leaky integrator, a conditional burster model, and a Hodgkin-Huxley type model with 14 different ionic currents. Inputs to the simulated neurons can be provided by data stored in files from actual experiments, allowing the making of ‘hybrid’ networks. The modelled neurons as well as the network are described using graphic tools. Neuron and network parameters can be modified during the simulation to mimic electrical stimulations and the action of drugs. After the simulation, the temporal behaviour of the network or of selected neurons can be visualised, and point process, frequential and dynamic analyses can be performed.
The XNBC project is supported by the DRET (Contract 91/1246A and 94/2526A).
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References
Bower, J, Beeman D. (1995) The Book of Genesis: exploring realistic neural models with the GEneral NEural Simulation System. Springer-Verlag, New-York.
De Schutter E. (1992) A consumer guide to neuronal modeling software. TINS 15, 462–464.
Geoffrois E, Edeline J-M., Vibert J-F. (1994) Learning by delay modifications. In F. H. Eeckman (ed.) Computation in neurons and neural systems. Kluwer Academic Publishers, Boston (USA), pp. 133–138.
Hines M. (1994) The Neuron simulation program. In J. Skrzypek (ed.) Neural Network Simulation Environments. Kluwer Academic Publishers, Boston (USA), pp. 148–163.
Hodgkin, A.L., Huxley, A.F., (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. Lond. 117, 500–544.
MacGregor, R.J., 1987, Neural and Brain Modeling. Academic Press,San Diego.
Segundo J. P., Vibert J-F, Stiber M., Hanneton S. (1995a) Periodically modulated inhibition and its post-synaptic consequences. I. General features. Influence of modulation frequency. Neuroscience 68, 657–692.
Segundo J. P., Stiber M., Vibert J-F, Hanneton S. (1995b) Periodically modulated inhibition and its post-synaptic consequences. II. Influence of pre-synaptic slope, depth, range, noise and of post-synaptic natural discharges. Neuroscience 68, 693–719.
Segundo J. P., Vibert J-F, Stiber M.. (1998) Periodically modulated inhibition and its post-synaptic consequences. III. The heterogeneity of the post synaptic spike train, and how control parameters affect it. Neuroscience 71.
Skrzypek J. (1994) Neural network simulation environments. Kluwer Academic Publishers, Boston, USA.
Vibert J-F, Pakdaman K., Azmy N. (1994a) Inter-neural delay modification synchronizes biologically plausible neural networks. Neural Networks, 7: 589–607.
Vibert J-F, Pakdaman K, Cloppet F, Azmy N. (1994b) NBC: a workstation for biological neural network simulation. In Skrzypek J (ed.) Neural network simulation environments. Kluwer Academic Publishers, Boston (USA), pp. 113–133.
Vibert J-F, Pakdaman K., Boussard E., Av-Ron E. (1996) Computational neuroscience and neurology. Nature-Medecine 1 1247–1248.
Vibert J-F., Pakdaman K., Boussard E., Av-Ron E. (1997) XNBC: a simulation tool. Application to the study of neural coding using hybrid networks. BioSystems 40 211–218.
Vibert J-F., Pham J., Pakdaman K, Azmy N. (1995) XNBC: A simulation tool for neurobiologists. In J. Bower (ed.) The neurobiology of Computation. Kluwer Academic Pub., Boston, USA, pp. 346–352.
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Vibert, JF. (2001). XNBC: Simulating Biological Neural Networks. In: Rasmussen, L.B., Beardon, C., Munari, S. (eds) Computers and Networks in the Age of Globalization. IFIP — The International Federation for Information Processing, vol 57. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-35400-2_20
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DOI: https://doi.org/10.1007/978-0-387-35400-2_20
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