Red Blood Cells and Hemoglobin in Hypoxic Pulmonary Vasoconstriction

  • Steven Deem
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 588)


Nitric oxide (NO) plays an important role in the modulation of hypoxic pulmonary vasoconstriction; in turn, red blood cells (RBCs) augment HPV by hemoglobin-mediated oxidation and inactivation of NO. In addition, scavenging of reactive oxygen species by RBCs may play a role in augmentation of HPV. NO delivery and/or production by RBCs does not appear to be important in the control of pulmonary vasomotor tone. This review will discuss regulation of HPV by RBCs with an emphasis on hemoglobin-NO interactions. In addition, the review will discuss how biologic (S-nitrosation) or pharmacologic (cross-linking) modification of hemoglobin may affect pulmonary circulatory-hemoglobin interactions.

Key Words

pulmonary blood flow gas exchange oxygen delivery 


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Authors and Affiliations

  • Steven Deem
    • 1
  1. 1.Departments of Anesthesiology and MedicineUniversity of Washington, Harborview Medical CenterSeattleUSA

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