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JNK Pathway as Therapeutic Target to Prevent Degeneration in the Central Nervous System

  • Mariaelena Repici
  • Tiziana Borsello
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 588)

Abstract

JNKs (c-Jun N-terminal kinases) are important transducing enzymes involved in many faces of cellular regulation such as gene expression, cell proliferation and programmed cell death. The activation of JNK pathway is critical for naturally occurring neuronal death during development as well as for pathological death of adult brain following different insults. In particular, JNKs play an important role in excitotoxicity and all related phenomena. Initial research concentrated on defining the components and organization of JNK signalling cascades, but more recent studies have begun to see JNK as the appropriate target for prevent cell loss. We used a specific JNK inhibitor, the cell permeable peptide D-JNKI1, to block JNK action in neuronal death following excitotoxicity in vitro and cerebral ischemia in vivo. Here we review our recent findings and we discuss the possibility of using D-JNKI1 as a therapeutic agent to prevent cell loss in the central nervous system.

Key Words

JNK inhibitors excitotoxicity neurodegeneration ischemic damage 

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Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Mariaelena Repici
    • 1
  • Tiziana Borsello
    • 1
    • 2
  1. 1.University of LausanneLausanneSwitzerland
  2. 2.Biol. Neurodeg. Disorders LabIstituto di ricerche Farmacologiche “Mario Negri”MilanoItaly

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