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Receptors and Pathways in Innate Antifungal Immunity

The Implication for Tolerance and Immunity to Fungi
  • Teresa ZelanteEmail author
  • Claudia Montagnoli
  • Silvia Bozza
  • Roberta Gaziano
  • Silvia Bellocchio
  • Pierluigi Bonifazi
  • Silvia Moretti
  • Francesca Fallarino
  • Paolo Puccetti
  • Luigina Romani
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 590)

Abstract

In the last years, the clinical relevance of fungal diseases has gained importance because of an increasing population of immunocompromised hosts, such as patients who have undergone transplants, patients with various types of leukemia, and people infected with HIV. Although some virulence factors are of obvious importance, pathogenicity cannot be considered an inherent characteristic of fungi.1 Fungi seem to have a complex relationship with the vertebrate immune system, mainly due to some prominent features: among these, the ability of dimorphic fungi to exist in different forms and to reversibly switch from one to the other in infection. Although association between morphogenesis and virulence has long been presumed for fungi that are human pathogens2, no molecular data unambiguously establish a role for fungal morphogenesis as a virulence factor. What fungal morphogenesis implicates through antigenic variability, phenotypic switching, and dimorphic transition is the existence of a multitude of recognition and effector mechanisms to oppose fungal infectivity at the different body sites.

Keywords

Treg Cell Invasive Aspergillosis Chronic Mucocutaneous Candidiasis Chronic Mucocutaneous Candidiasis Tryptophan Catabolism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Teresa Zelante
    • 1
    Email author
  • Claudia Montagnoli
    • 1
  • Silvia Bozza
    • 1
  • Roberta Gaziano
    • 1
  • Silvia Bellocchio
    • 1
  • Pierluigi Bonifazi
    • 1
  • Silvia Moretti
    • 1
  • Francesca Fallarino
    • 1
  • Paolo Puccetti
    • 1
  • Luigina Romani
    • 1
  1. 1.Dept. of Experimental Medicine and Biochemical SciencesUniversity of PerugiaPerugiaItaly

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