CD4+ T Cells Cooperate With Macrophages for Specific Elimination of MHC Class II-Negative Cancer Cells

  • Alexandre Corthay
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 590)


Our present knowledge of how T cells eliminate cancer is mainly based on memory immune responses investigated with vaccinated mice1,2. In-vivo depletion studies with anti-CD4 monoclonal antibodies (mAb) have revealed that the antitumor immunity conferred by prophylactic vaccination is usually CD4+ T cell dependent. CD4+ T cells were required for vaccination-induced immunity against the B16 melanoma3, 4, 5, against the Mc51.9 fibrosarcoma6, against the J558 plasmacytoma7, and against the A20 lymphoma7.


Myeloma Cell SCID Mouse Antitumor Immunity Tumor Rejection Tumor Eradication 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Alexandre Corthay
    • 1
  1. 1.Institute of ImmunologyUniversity of Oslo and Rikshospitalet-Radiumhospitalet Medical CenterOsloNorway

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