CD28 and Cd27 Costimulation of Cd8+ T Cells: A Story of Survival

  • Douglas V. Dolfi
  • Peter D. Katsikis
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 590)


The role of costimulation in antiviral CD8+ T cells responses is becoming increasingly important as we try to develop adjuvant technologies for therapeutic or vaccine applications. Understanding how costimulation signals work and being able to harness their function to promote robust and protective immune responses is of particular interest. Much of current immunological research is addressing the many costimulatory molecules that are being discovered and characterized in order to elucidate the different mechanisms by which they work. It is becoming clear that multiple costimulation molecules are involved during the different phases of the CD8+ T cell response providing important proliferative and survival signals for these cells. The concept of T cell costimulation has evolved from the initial concept of the single CD28 second signal to an increasingly complex array of costimulation signals that involve multiple members of the B7:CD28 and TNFα/TNFR families. This review will focus on CD28 and CD27 costimulation and examine their involvement in the costimulation of CD8+ T cell responses and the role of such costimulation in the survival of activated, resting, and memory CD8+ T cells. We will also examine the importance of costimulatory-induced survival in antiviral CD8+ T cell responses.


Cell Response Costimulatory Molecule Secondary Response CD27 Costimulation Single Positive 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Douglas V. Dolfi
    • 1
  • Peter D. Katsikis
    • 1
  1. 1.Department of Microbiology and ImmunologyDrexel University College of MedicinePhiladelphiaUSA

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