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Germinal Center-Derived B Cell Memory

  • Craig P. Chappell
  • Joshy Jacob
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 590)

Abstract

B cell memory is characterized by persistent levels of Ag-specific serum antibody (Ab) following immunization and the ability to rapidly produce Ab upon secondary Ag exposure1. During primary immune responses in mammals, B cell activation occurs within or at the border of T cell-rich periarteriolar lymphoid sheaths following cognate interaction with CD4 TH cells2,3. This interaction induces B lymphocytes to differentiate into either foci of antibody-forming cells (AFC) found in red pulp and follicular borders or germinal center (GC) B cells located within secondary follicles2, 3, 4. The primary foci response in mice is relatively short lived (5–10 days); in contrast, the GC response is a more sustained program of cellular differentiation in which extensive B cell proliferation, somatic hypermutation of IgV gene segments, and memory cell selection occurs4, 5, 6, 7, 8. While GC B cells are readily identified using cell surface attributes, no such markers have been identified on murine memory B cells. The inability to reliably identify memory B cells has hampered the study of memory B cell development and differentiation.

Keywords

Cell Memory Germinal Center Adoptive Transfer ELISPOT Assay Primary Immune Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Craig P. Chappell
    • 1
  • Joshy Jacob
    • 1
  1. 1.Department of Microbiology and ImmunologyEmory UniversityAtlanta

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