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Signal Transduction in DC Differentiation: Winged Messengers and Achilles’ Heel

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Book cover Crossroads between Innate and Adaptive Immunity

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 590))

Abstract

Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.

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  1. University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Inna Lindner, Pedro J. Cejas, Louise M. Carlson, Julie Torruellas, Gregory V. Plano & Kelvin P. Lee

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  1. Inna Lindner
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  2. Pedro J. Cejas
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  1. Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

    Peter D. Katsikis

  2. La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

    Stephen P. Schoenberger

  3. Emory Vaccine Center, Emory University, Atlanta, Georgia, USA

    Bali Pulendran

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Lindner, I., Cejas, P.J., Carlson, L.M., Torruellas, J., Plano, G.V., Lee, K.P. (2007). Signal Transduction in DC Differentiation: Winged Messengers and Achilles’ Heel. In: Katsikis, P.D., Schoenberger, S.P., Pulendran, B. (eds) Crossroads between Innate and Adaptive Immunity. Advances in Experimental Medicine and Biology, vol 590. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34814-8_1

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