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Signal Transduction in DC Differentiation: Winged Messengers and Achilles’ Heel

  • Inna Lindner
  • Pedro J. Cejas
  • Louise M. Carlson
  • Julie Torruellas
  • Gregory V. Plano
  • Kelvin P. Lee
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 590)

Abstract

Dendritic cells (DC) are centrally involved in the initiation and regulation of the adaptive immune response, and different DC can have markedly different (e.g., opposing) function. Acquisition of specific functions is likely to be a result of both nature and nurture, namely differentiation of progenitors into distinct DC subsets as well as the influence of environmental signals. This is not unlike what is seen for T and B cells. This review will focus on the signal transduction pathways that allow an unusually wide range of hematopoietic progenitors to differentiate into DC, the functional characteristics regulated by these pathways, and the ability of pathogens to alter DC function by subverting these pathways during progenitor→DC differentiation.

Keywords

Dendritic Cell Yersinia Enterocolitica Human Dendritic Cell Dendritic Cell Subset Dendritic Cell Differentiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Inna Lindner
    • 1
  • Pedro J. Cejas
    • 1
  • Louise M. Carlson
    • 1
  • Julie Torruellas
    • 1
  • Gregory V. Plano
    • 1
  • Kelvin P. Lee
    • 1
  1. 1.University of Miami Miller School of MedicineMiamiUSA

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