Abstract
Entry of Plasmodium falciparum into human red blood cells is a stressful event for both the host and the parasite. Conversion of hemoglobin into usable food by P. falciparum is accompanied by the production of chemically reactive and toxic molecules called oxidants. Examination of the temporal sequence of gene expression during the intraerythrocytic development cycle (IDC) [Bozdech, Z., et al., PLoS Biology, 1(1) (2003), 1–16] can help elucidate how Plasmodium responds to these self-generated harmful chemicals while proceeding through its normal developmental program. Our study has three parts: identification of temporally-defined sets of co-regulated oxidative stress response genes in this parasite; comparison of the temporal patterns of the oxidative stress response to that of co-regulated gene sets involved in other processes; and identification of putative transcription factor binding sites by finding DNA motifs unique to the upstream regions of co-regulated oxidative stress response genes.
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References
Bailey, T.L. and Elkan, C., Fitting a mixture model by expectation maximization to discover motifs in biopolymers, in: Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, AAAI Press, Menlo Park, CA, 1994, pp. 28–36.
Becker, K., Tilley, L., Vennerstrom, J.L., Roberts, D., Rogerson, S., and Ginsburg, H., Oxidative stress in malaria parasite-infected erythrocytes: Host-parasite interactions, International Journal for Parasitology, 34 (2004), 163–189.
Bozdech, Z. and Ginsburg, H., Antioxidant defense in Plasmodium falciparum: Data mining of the transcriptone, Malaria Journal, 3 (2004), 23.
Bozdech, Z., Llinás, M., Pulliam, B.L., Wong, E.D., Zhu, J., and DeRisi, J.L., The transcriptome of the intraerythrocytic development cycle of Plasmodium falciparum, PLoS Biology, 1(1) (2003), 1–16.
Carmel-Harel, O. and Storz, G., Roles of the glutathione-and thioredoxin-dependent reduction systems in Escherichia coli and Saccharomyces cervisiae responses to oxidative stress, Annu. Rev. Microbiol., 54 (2000), 439–461.
Causton, H.C., et al., Remodeling of yeast genome expression in response to environmental changes, Mol. Biol. Cell, 12(2) (2001), 323–337.
Chen, D., et al., Global transcriptional responses of fission yeast to environmental stress, Mol. Biol. Cell, 14(1) (2003), 214–229.
Gasch, A.P., Spellman, P.T., Kao, C.M., Carmel-Harel, O., Eisen, M.B., Storz, G., Botstein, D., and Brown, P.O., Genomic expression programs in the response of yeast cells to environmental changes, Molecular Biology of the Cell, 11 (2000), 4241–4257.
Grundy, W.N., Bailey, T.L., Elkan, C.P., and Baker, M.E., Meta-MEME: Motif-based hidden Markov models of protein families, Computer Applications in the Biosciences, 13(4) (1997), 397–406.
Pomposiello, P.J. and Demple, B., Global adjustment of microbial physiology during free radical stress, Adv. Microb. Physiol., 46 (2002), 319–341.
Zheng, M., et al., DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide, J. Bacteriol., 183(15) (2001), 4562–4570.
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Noyola-Martinez, J. et al. (2007). Oxidative Stress Genes in Plasmodium falciparum as Indicated by Temporal Gene Expression. In: McConnell, P., Lin, S.M., Hurban, P. (eds) Methods of Microarray Data Analysis V. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34569-7_4
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DOI: https://doi.org/10.1007/978-0-387-34569-7_4
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-34568-0
Online ISBN: 978-0-387-34569-7
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