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Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor

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Book cover Tissue Engineering

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 585))

Abstract

There is a significant need for therapies to enhance healing in large skeletal defects because there exist over 1 million cases each year of patients requiring bone graft procedures to correct such defects1. These defects can arise for a variety of reasons including trauma, congenital deformity, and tumor resection and thus exist in a wide range of shapes, sizes, and functional locations. The most successful of current treatments for large bone defects is autologous bone graft. This therapy is attractive because there is no risk of immune rejection to the transplanted tissue; however, there are two major drawbacks associated with this procedure. First, there is a limited supply of donor bone, which is harvested primarily from the trabecular bone of the iliac crest, or from a whole rib or fibula. Thus, there may not be enough donor tissue for proper shape reconstruction of the defect that can also support the necessary mechanical load during healing.2 Second, autologous bone graft therapies are associated with a risk of morbidity at the donor site which was healthy to begin with. Due to these issues, there is a need for alternative strategies to bone healing that allow exact shape reconstruction, are mechanically strong, and are biocompatible in both the short and long term. To this end, bone tissue engineering has evolved as a practical method of regenerating large bony defects.

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Authors and Affiliations

  1. Department of Bioengineering, Rice University, Houston, TX, USA

    Heidi L. Holtorf & Antonios G. Mikos

  2. Department of Periodontology and Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands

    John A. Jansen

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  1. Heidi L. Holtorf
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  2. John A. Jansen
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  3. Antonios G. Mikos
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Editors and Affiliations

  1. University of Maryland, College Park, MD, 20742, USA

    John P. Fisher

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Holtorf, H.L., Jansen, J.A., Mikos, A.G. (2006). Modulation of Cell Differentiation in Bone Tissue Engineering Constructs Cultured in a Bioreactor. In: Fisher, J.P. (eds) Tissue Engineering. Advances in Experimental Medicine and Biology, vol 585. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-34133-0_16

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  • DOI: https://doi.org/10.1007/978-0-387-34133-0_16

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