Skip to main content
SpringerLink
Log in

Neuronal Dysfunction and Cognitive Impairment Resulting from Inactivation of the Egr-Family Transcription Factor zif268

  • Chapter
Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abraham WC, Dragunow M, Tate WP (1991). The role of immediate early genes in the stabilization of long-term potentiation. Mol Neurobiol 5:297–314.

    PubMed  CAS  Google Scholar 

  • Abraham WC, Mason SE, Demmer J, Williams JM, Richardson CL, Tate WP, Lawlor PA, Dragunow M (1993). Correlations between immediate early gene induction and the persistence of long-term potentiation. Neuroscience 56:717–727.

    Article  PubMed  CAS  Google Scholar 

  • Alberini CM (2005). Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci 26:51–56.

    Article  CAS  Google Scholar 

  • Beckman AM, Wilce PA (1997). Egr transcription factors in the nervous system. Neurochem Int 31:477–510.

    Article  Google Scholar 

  • Bliss TVP, Lomo T (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. J Physiol 232:331–356.

    PubMed  CAS  Google Scholar 

  • Bolhuis JJ, Zijlstra GO, den Boer-Visser AM, Van der Zee EA (2000). Localised neuronal activation in the zebra finch brain is related to the strength of song learning. Proc Natl Acad Sci USA 97:2282–2285.

    Article  PubMed  CAS  Google Scholar 

  • Bozon B, Davis S, Laroche S (2002). Regulated transcription of the immediate-early gene Zif268: mechanisms and gene dosage-dependent function in synaptic plasticity and memory formation. Hippocampus 12:570–577.

    Article  PubMed  CAS  Google Scholar 

  • Bozon B, Davis S, Laroche S (2003). A requirement for the immediate early gene zif268 in reconsolidation of recognition memory after retreival. Neuron 40:695–701.

    Article  PubMed  CAS  Google Scholar 

  • Burmeister SS, Fernald RD (2005). Evolutionary conservation of the egr-1 immediate-early gene response in a teleost. J Comp Neurol 48:220–232.

    Article  CAS  Google Scholar 

  • Chandhuri A, Matsubara JA, Cynader MS (1995). Neuronal activity in primate visual cortex assessed by immunostaining for the transcription factor Zif268. Vision Neurosci 12:35–50.

    Article  Google Scholar 

  • Christy BA, Lau LF, Nathans D (1988). A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with “zinc finger” sequences. Proc Natl Acad Sci USA 85:7857–7861

    Article  PubMed  CAS  Google Scholar 

  • Christy BA, Nathans D (1989). DNA binding site of the growth factor-inducible protein Zif268. Proc Natl Acad Sci USA 86:8737–8741.

    Article  PubMed  CAS  Google Scholar 

  • Clark RE, Zola SM, Squire LR (2000). Impaired recognition memory in rats after damage to the hippocampus. J Neurosci 20:8853–8860.

    PubMed  CAS  Google Scholar 

  • Cole AJ, Saffan DW, Baraban JM, Worley PF (1989). Rapid increase if an immediate early gene messsenger RNA in hippocampal neurons by synapticNMDA receptor activation. Nature 340:474–476.

    Article  PubMed  CAS  Google Scholar 

  • Davis HP, Squire LR (1984). Protein synthesis and memory. A review. Psychol Bull 95:518–559.

    Article  Google Scholar 

  • Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S (2000). The MAPK/ERK cascate targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J Neurosci 20:4563–4572.

    PubMed  CAS  Google Scholar 

  • Davis S, Bozon B, Laroche S (2003). How necessary is the activation of the immediate early gene zif268 in synaptic plasticity and learning? Behav Brain Res 142:17–30.

    Article  PubMed  CAS  Google Scholar 

  • Debiec J, LeDoux JE, Nader K (2002). Cellular and systems reconsolidation in the hippocampus. Neuron 36:527–538.

    Article  PubMed  CAS  Google Scholar 

  • Desjardins S, Mayo W, Vallee M, Hancock D, Le Moal M, Simon H, Abrous DN (1997). Effect of aging on the basal expression of c-Fos, c-Jun, and Egr-1 proteins in the hippocampus. Neurobiol Aging 18:37–44.

    Article  PubMed  CAS  Google Scholar 

  • Dickey CA, Loring JF, Montgomery J, Gordon MN, Eastman PS, Morgan D (2003). Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J Neurosci 23:5219–5226.

    PubMed  CAS  Google Scholar 

  • Dragunow M (1996). A role for immediate early transcription factors in learning and memory. Behav Genetics 20:293–299.

    Article  Google Scholar 

  • Duvarci S, Nader K, LeDoux JE (2005). Activation of extracellular signal-regulated kinase-mitogenactivated protein kinase cascade in the amygdala is required for memory reconsolidation of auditory fear conditioning. Eur J Neurosci 21:283–289.

    Article  PubMed  Google Scholar 

  • Ennanceur A, Delacour J (1988). A new one-trial test for neurobiological studies of memory in rats: 1. Behavioural data. Behav Brain Res 100:85–92.

    Google Scholar 

  • Frankland PW, Bontempi B, Talton LE, Kaczmarek L, Silva AJ (2004). The involvement of the anterior cingulate cortex in remote contextual fear memory. Science 304:881–883.

    Article  PubMed  CAS  Google Scholar 

  • French PJ, O’Connor V, Jones MW, Davis S, Errington ML, Voss K, Truchet B, Wotjak C, Stean T, Doyere V, Maroun M, Laroche S, Bliss TVP (2001). Subfield-specific immediate early gene expression associated with hippocampal long-term potentiation in vivo. Eur J Neurosci 13:868–976.

    Article  Google Scholar 

  • Frey U, Morris RG (1997). Synaptic tagging and long-term potentiation. Nature 385:533–536.

    Article  PubMed  CAS  Google Scholar 

  • Gashler A, Sukhatme VP (1995). Early growth-response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog Nucl Acid Res Mol Biol 50:191–224.

    Article  CAS  Google Scholar 

  • Grimm R, Tishmeyer W (1997). Complex patterns of immediate early gene induction in rat brain following brightness discrimination training and pseudotraining. Behav Brain Res 84:109–116.

    Article  PubMed  CAS  Google Scholar 

  • Guzowski JF, Setlow B, Wagner EK, McGaugh JL (2001). Experience-dependent gene expression in the rat hippocampus after spatial learning: a comparison of the immediate-early genes Arc, c-fos, and zif268. J Neurosci 21:5089–5098.

    PubMed  CAS  Google Scholar 

  • Guzowski JF (2002). Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus 12:86–104.

    Article  PubMed  CAS  Google Scholar 

  • Hall J, Thomas KL, Everitt BJ (2000). Rapid and selective induction of BDNF expression expression in the hippocampus during contextual learning. Nat Neurosci 3:533–535.

    Article  PubMed  CAS  Google Scholar 

  • Hall J, Thomas KL, Everitt BJ (2001). Cellular imaging of zif268 expression in the hippocampus and amygdala during contextual and cued fear memory retreival: selective activation of hippocampal CA1 neurons during the recall of contextual memories. J Neurosci 21:2186–2193.

    PubMed  CAS  Google Scholar 

  • Herms J, Zurmöhle U, Schlingensiepen R, Brysch W, Schlingensiepen KH (1994). Developmental expression of the transcription factor zif268 in rat brain. Neurosci Lett 165:171–174.

    Article  PubMed  CAS  Google Scholar 

  • Heynen AJ, Bear MF (2001). Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo. J Neurosci 15:9801–9813.

    Google Scholar 

  • Jarvis ED, Mello CV, Nottebohm F (1995). Associative learning and stimulus novelty influence in the song-induced expression of an immediate early gene in the canary forebrain. Learn Memory 2:62–80.

    CAS  Google Scholar 

  • Jones MW, French PJ, Bliss TVP, Rosenblum K (1999). Molecular mechanisms of long-term potentiation in the insular cortex in vivo. J Neurosci 19:RC36.

    PubMed  CAS  Google Scholar 

  • Jones MW, Errington ML, French PJ, Fine A, Bliss TV, Garel S, Charnay P, Bozon B, Laroche S, Davis S (2001). A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories. Nat Neurosci 4:289–296.

    Article  PubMed  CAS  Google Scholar 

  • Judge ME, Quartermain D (1982). Characteristics of retrograde amnesia following reactivation of memory in mice. Physiol Behav 28:585–590.

    Article  PubMed  CAS  Google Scholar 

  • Kelly A, Laroche S, Davis S (2003). Activation of mitogen-activated protein kinase/extracellular signal-regulated kinase in hippocampal circuitry is required for consolidation and reconsolidation of recognition memory. J Neurosci 23:5354–5360.

    PubMed  CAS  Google Scholar 

  • Kida S, Josselyyn SA, Pena de Ortiz S, Kogan JH, Chevere I, Masushige S, Silva AJ (2002). CREB required for the stability of new and reactivated memories. Nat Neurosci 5:248–355.

    Article  CAS  Google Scholar 

  • Kilduff TS, Vugrinic C, Lee SL, Milbrandt JD, Mikkelsen JD, O’Hara BF, Heller HC (1998). Characterization of the circadian system of NGFI-A and NGFI-A/NGFI-B deficient mice. J Biol Rhythms 13:347–357.

    Article  PubMed  CAS  Google Scholar 

  • Knapska E, Kaczmarek L (2004). A gene for neuronal plasticity in the mammalian brain: Zif268/Egr-1/NGFI-A/Krox-24/TIS8/ZENK? Prog Neurobiol 74:183–211.

    Article  PubMed  CAS  Google Scholar 

  • Krug M, Lossner, B, Ott T (1984). Anisomycin blocks the late phase of LTP in the dentate gyrus of freely moving rats. Brain Res Bull 13:39–42.

    Article  PubMed  CAS  Google Scholar 

  • Lee SL, Sadovsky Y, Swirnoff AH, Polish JA, Goda P, Gavrinian G, Milbrandt J (1996). Luteininzing hormone deficiency and female infertility in mice lacking the transcription factor NGF1-A (Egr-1). Science 273:1219–1221.

    PubMed  CAS  Google Scholar 

  • Lee JL, Everitt BJ, Thomas KL (2004). Independent cellular processes for hippocampal memory consolidation and reconsolidation. Science 304:839–843.

    Article  PubMed  CAS  Google Scholar 

  • Lemaire P, Revelant O, Bravo R, Charnay P (1988). Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells. Proc Natl Acad Sci USA 85:4691–4695.

    Article  PubMed  CAS  Google Scholar 

  • Lewis DJ (1979). Psychobiology of active and inactive memory. Psychol Bull 86:1054–1083.

    Article  PubMed  CAS  Google Scholar 

  • Mack K, Day M, Milbrandt J, Gottlieb DI (1990). Localization of the NGF1-A protein in the rat brain. Mol Brain Res 8:177–180.

    Article  PubMed  CAS  Google Scholar 

  • Mactus CF, Ricco DC, Ferek JM (1979). Retrograde amnesia for old (reactivated) memory:some anomalous characteristics. Science 204:1319–1320.

    Article  Google Scholar 

  • Malkani S, Rosen JB (2000). Specific induction of early growth response gene 1 in the lateral nucleus of the amygdalal following contextual fear conditioning in rats. Neuroscience 97:693–702.

    Article  PubMed  CAS  Google Scholar 

  • Malkani S, Wallace KJ, Donley MP, Rosen JB (2004). An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning. Learn Memory 11:617–624.

    Article  Google Scholar 

  • Manns JR, Hopkins RO, Reed JM, Kitchener EG, Squire LR (2003). Recognition memory and the human hippocampus. Neuron 37:171–180.

    Article  PubMed  CAS  Google Scholar 

  • Mataga N, Fujishima S, Condie BG, Hensch TK (2001). Experience-dependent plasticity of mouse visual cortex in the absence of the neuronal activity-dependent marker egr1/zif268. J Neurosci 21:9724–9732.

    PubMed  CAS  Google Scholar 

  • Meiri N, Rosenblum K (1998). Lateral ventricle injection of the protein synthesis inhibitor anisomycin impairs long-term memory in a spatial memory task. Brain Res 789:48–55.

    Article  PubMed  CAS  Google Scholar 

  • Mello CV, Vicario DS, Clayton DF (1992). Song presentation induces gene expression in the sondbird forebrain. Proc Natl Acad Sci USA 89:6818–6822.

    Article  PubMed  CAS  Google Scholar 

  • Milbrandt J (1987). A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797–799.

    Article  PubMed  CAS  Google Scholar 

  • Milekic MH, Alberini CM (2002). Temporally graded requirement for protien synthsisi following memory reactivation. Neuron 36:521–525.

    Article  PubMed  CAS  Google Scholar 

  • Misanin JR, Miller RR, Lewis DJ (1968). Retrograde amnesia produced by electroconvulsive shock after ractivation of consolidated memory trace. Science 160:554–555.

    Article  PubMed  CAS  Google Scholar 

  • Myers KM, and Davis M (2002). System-level reconsolidation: reengagement of the hippocampus with memory reactivation. Neuron 36:340–343.

    Article  PubMed  CAS  Google Scholar 

  • Nader K, Schafe GE, LeDoux JE (2000). Fear memories require protein synthesis in the amygdala for reconsolidation after retrieval. Nature 406:722–726.

    Article  PubMed  CAS  Google Scholar 

  • Nader K (2003). Memory traces unbound. Trends Neurosci 26:65–72.

    Article  PubMed  CAS  Google Scholar 

  • Nguyen PV, Abel T, Kandel ER (1994). Requirement of a critical period of transcription for induction of a late phase of LTP. Science 265:1104–1107.

    Article  PubMed  CAS  Google Scholar 

  • Nikolaev E, Kaminska B, Tishmeyer W, Matthies H, Kaczmarek L (1992). Induction of expression of genes encoding transcription factors in the rat brain elicted by gehavioural traning. Brain Res Bull 28:479–484.

    Article  PubMed  CAS  Google Scholar 

  • O’Donovan KJ, Tourtellotte WG, Milbrandt J, Baraban JM (1999). The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuronscience. Trends Neurosci 22:167–173.

    Article  PubMed  CAS  Google Scholar 

  • Okuno H, Miyashita Y (1996). Expression of the transcription factor Zif268 in the temoral cortex of monkeys during visual paired associate learning. Eur J Neurosci 8:2118–2128.

    Article  PubMed  CAS  Google Scholar 

  • Otani S, Marshall CJ, Tate WP, Goddard GV, Abraham WC (1989). Maintenance of LTP in rat dentate gyrus requires protein synthesis but not mRNA synthesis immediately post-tetanization. Neuroscience 28:519–526.

    Article  PubMed  CAS  Google Scholar 

  • Pinaud R (2004). Experience-dependent immediate early gene expression in the adult central nervous system: evidence from enriched-environment studies. Int J Neurosci 114:321–333.

    Article  PubMed  CAS  Google Scholar 

  • Przybyslawski J, Sara S (1997). Reconsolidation of memory after its reactivation. Behav Brain Res 84:241–246.

    Article  PubMed  CAS  Google Scholar 

  • Richardson CL, Tate WP, Mason SE, Lawlor PA, Dragunow M, Abraham WC (1992). Correlation between the induction of an immediate early gene, zif/268, and long-term potentiation in the dentate gyrus. Brain Res 580:147–154.

    Article  PubMed  CAS  Google Scholar 

  • Sara S (2000). Retrieval and reconsolidation toward a neurobiology of remembering. Learn Memory 7:73–84.

    Article  CAS  Google Scholar 

  • Spektor BS, Miller DW, Hollingsworth ZR, Kaneko YA, Solano SM, Johnson JM, Penney JB Jr, Young AB, Luthi-Carter R (2002). Differential D1 and D2 receptor-mediated effects on immediate early gene induction in a transgenic mouse model of Huntington’s disease. Mol Brain Res 102:118–128.

    Article  PubMed  CAS  Google Scholar 

  • Sukhatme VP, Cao XM, Chang LC, Tsai-Morris CH, Stamenkovich D, Ferreira PC, Cohen DR, Edwards SA, Shows TB, Curran T (1988). A zinc finger-encoding gene coregulated wit hc-fos during growth and differentiation, and after cellular depolarization. Cell 53:37–43.

    Article  PubMed  CAS  Google Scholar 

  • Swirnoff AH, Milbrandt J (1995). DNA-binding specificity of NGF1-A and related zinc finger transcription factors. Mol Cell Biol 15:2275–2287.

    PubMed  CAS  Google Scholar 

  • Thomas KL, Hall J, Everitt BJ (2002). Cellular imaging with zif268 expression in the rat nucleus accumbens and the frontal cortex further dissociated the neural pathways activated following the retrieval of contextual and cued memory. Eur J Neurosci 16:1789–1996.

    Article  PubMed  Google Scholar 

  • Tishmeyer W, Grimm R (1999). Activation immediate early genes and memory formation. Cell Mol Life Sci 55:564–574.

    Article  Google Scholar 

  • Tokuyama W, Okuno H, Hashimoto T, Li YX, Miyashita Y (2002). Selective zif268 mRNA induction in the perirhinal cortex of macaque monkeys during formation of visual pair-association memory. J Neurochem 81:60–70.

    Article  PubMed  CAS  Google Scholar 

  • Topilko P, Schneider-Maunoury S, Levy G, Trembleau A, Gourdji D, Driancourt MA, Rao CV, Charnay P (1998). Multiple pituitary and ovarian defcts in krox-24 (NGF1-A, Egr-1)-targeted mice. Mol Endocrinol 12:107–122.

    Article  PubMed  CAS  Google Scholar 

  • Watson MA, Milbrandt J (1990). Expression of the nerve growth factor-regulated NGF1-A and NGF1-B genes in the developing rat. Development 110:173–183.

    PubMed  CAS  Google Scholar 

  • Wei F, Xu ZC, Qu Z, Milbrandt J, Zhuo M (2000). Role of EGR1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation. J Cell Biol 149:1325–1334.

    Article  PubMed  CAS  Google Scholar 

  • Weitemier AZ, Ryabinin AE (2004). Subregion-specific differences in hippocampal activity between Delay and Trace fear conditioning: an immunohistochemical analysis. Brain Res 995:55–65.

    Article  PubMed  CAS  Google Scholar 

  • Williams J, Dragunow M, Lawlor PA, Mason SE, Abraham WC, Leah J, Bravo R, Demmer J, Tate W (1995). Krox20 may play a key role in the stabilisation of long-term potentiation. Mol Brain Res 28:87–93.

    Article  PubMed  CAS  Google Scholar 

  • Wisden W, Errington ML, Williams S, Dunnett SB, Waters C, Hitchcock D, Evans G, Bliss TV, Hunt SP (1990). Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4:603–614.

    Article  PubMed  CAS  Google Scholar 

  • Worley PF, Christy BA, Nakabeppu Y, Bhat RV, Cole AJ, Baraban JM (1991). Constitutive expression of zif268 in neocortex is regulated by synaptic activity. Proc Natl Acad Sci USA 88:5106–5110.

    Article  PubMed  CAS  Google Scholar 

  • Worley PF, Bhat RV, Baraban JM, Erickson CA, McNaughton BL, Barnes CA (1993). Thresholds of synaptic activation of transcription factors in hippocampus: correlation with long-term enhancement. J Neurosci 13:4776–4786.

    PubMed  CAS  Google Scholar 

  • Yamagata K, Kaufmann WE, Lanahan A, Papapavlous M, Barnes CA, Andreasson KI, Worley PF (1994). Egr/Pilot Egr-1, a zinc finger transcription factor, is rapidly regulated by activity in brain neurons and colocalize with Egr-1/zif268. Learn Memory 1:140–152.

    CAS  Google Scholar 

  • Yau JL, Olsson T, Morris RG, Noble J, Seckl JR (1996). Decreased NGFI-A gene expression in the hippocampus of cognitively impaired aged rats. Mol Brain Res 42:354–357.

    Article  PubMed  CAS  Google Scholar 

  • Zheng D, Butler LS, McNamara JO (1998). Kindling and associated mossy fibre sprouting are not affected in mice deficient of NGFI-A/NGFI-B genes. Neuroscience 83:251–258.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratoire de Neurobiologie de l’Apprentissage, de la Mémoire et de la Communication, CNRS UMR 8620, Université Paris-Sud, 91405, Orsay, France

    Sabrina Davis, Megan Libbey & Serge Laroche

Authors
  1. Sabrina Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Megan Libbey
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Serge Laroche
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Neurobiology, Duke University Medical Center, Durham, NC, USA

    Raphael Pinaud Ph.D.  & Liisa A. Tremere Ph.D.  & 

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Springer Science + Business Media, LLC

About this chapter

Cite this chapter

Davis, S., Libbey, M., Laroche, S. (2006). Neuronal Dysfunction and Cognitive Impairment Resulting from Inactivation of the Egr-Family Transcription Factor zif268. In: Pinaud, R., Tremere, L.A. (eds) Immediate Early Genes in Sensory Processing, Cognitive Performance and Neurological Disorders. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-33604-6_10

Download citation

Publish with us

Policies and ethics

Search

Navigation