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Specimen Identification Through DNA Analysis

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Molecular Pathology in Clinical Practice

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Abstract

Analysis of identity through DNA typing has its origins in forensic identity testing and parentage testing. These same analyses also have found tremendous clinical utility in pathology laboratories for a variety of sample identification applications.1–9 These applications include identification of mislabeled specimens of all types, identification of histologic “floaters” in surgical pathology specimens, and detection of maternal cell contamination in prenatal specimens. The scientific principles and technologies of identity testing are described in the preceding chapters. This chapter focuses on sample issues and result interpretation, which are specific to sample identification and related applications of identity testing in the clinical laboratory.

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References

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Author information

Authors and Affiliations

  1. Molecular Pathology Laboratory, Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, NH, 03756, USA

    Gregory J. Tsongalis PhD (Director)

  2. Department of Pathology, Hartford Hospital, Hartford, CT, 06102, USA

    Andrew Ricci Jr. MD

Authors
  1. Gregory J. Tsongalis PhD
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  2. Andrew Ricci Jr. MD
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Editor information

Editors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital, New York, NY, 10021, USA

    Debra G. B. Leonard MD, PhD (Professor and Vice Chair for Laboratory Medicine) (Professor and Vice Chair for Laboratory Medicine)

  2. Hematology, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Adam Bagg MD (Director) (Director)

  3. Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA, 30322, USA

    Angela M. Caliendo MD, PhD (Vice Chair and Associate Professor) (Vice Chair and Associate Professor)

  4. Northwestern University Feinberg School of Medicine, Evanston, IL, 60201

    Karen L. Kaul MD, PhD (Professor) (Professor)

  5. Department of Pathology and Laboratory Medicine, Evanston Northwestern Healthcare, Evanston, IL, 60201, USA

    Karen L. Kaul MD, PhD (Professor) (Professor)

  6. Molecular Pathology Laboratory, Department of Pathology and Laboratory Medicine, University of Pennsylvania Health System, Philadelphia, PA, 19104, USA

    Vivianna M. Van Deerlin MD, PhD (Director) (Director)

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© 2007 Springer Science+Business Media, LLC

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Tsongalis, G.J., Ricci, A. (2007). Specimen Identification Through DNA Analysis. In: Leonard, D.G.B., Bagg, A., Caliendo, A.M., Kaul, K.L., Van Deerlin, V.M. (eds) Molecular Pathology in Clinical Practice. Springer, New York, NY. https://doi.org/10.1007/978-0-387-33227-7_47

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  • DOI: https://doi.org/10.1007/978-0-387-33227-7_47

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-33226-0

  • Online ISBN: 978-0-387-33227-7

  • eBook Packages: MedicineMedicine (R0)

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