Molecular Detection of Occult Tumor Cells

  • Karen L. Kaul


One of the key roles performed by pathologists is determination of the presence or absence of tumor cells in clinical samples. This is the basis for most approaches to staging, monitoring response to treatment, and detecting relapse of neoplasia and, as such, is a critical step in determining the course of patient management. Pathologists have utilized a variety of approaches, continually seeking to improve performance and thus patient outcome. The literature reflects this quest, including reports assessing the increased sensitivity afforded by step sectioning, immunohistochemistry, flow cytometry, and, more recently, molecular approaches for the detection of tumor cells in blood, bone marrow, and lymph node samples. The goal is, of course, the more accurate detection of disease spread and, ultimately, better patient care.


Breast Cancer Clin Oncol Radical Prostatectomy Circulate Tumor Cell Molecular Detection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Karen L. Kaul
    • 1
    • 2
  1. 1.Northwestern University Feinberg School of MedicineEvanston
  2. 2.Department of Pathology and Laboratory MedicineEvanston Northwestern HealthcareEvanstonUSA

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