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More than 18,000 people were diagnosed with and more than 13,000 died from primary brain tumors in 2003.1 The most common of the primary brain tumors is gliomas. Depending on the grade and morphologic type of glioma, newly diagnosed patients receive watchful waiting, surgical resection, radiotherapy, or chemotherapy, or some combination of these therapies. Regardless of therapy, most patients will progress and have a high risk of mortality and reduced quality of life. Thus, there has been intense interest in understanding the biology and genetics of gliomas, to provide better diagnostic tools and new therapeutic approaches. Molecular pathology markers are being identified that have been or will soon prove to be clinically useful in the practice of clinical neurooncology (see Table 27-1).
KeywordsEpidermal Growth Factor Receptor Glioblastoma Multiforme TP53 Mutation Anaplastic Astrocytoma Astrocytic Tumor
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- 14.Feldkamp MM, Roncari L, Lau N, Salhia B, Guha A. Expression of EGFRvIII is a better prognostic marker for GBM than either EGFR expression or the Ki-67 labeling index. Neuro-oncol. 2002;4:343.Google Scholar
- 29.Randazzo L, Scarpace L, Lemke N, et al. Tumoral and chromosomal heterogeneity in oligodendrogliomas detected with medium-throughput 1p/19q LOH analysis. Neuro-oncol. 2002;4:346.Google Scholar
- 34.Mischel PS, Shai R, Choe GY, et al. Identification of distinctive subtypes of primary glioblastoma multiforme by gene expression profiling. Neuro-oncol. 2002;4:330.Google Scholar
- 35.Nutt CL, Mani DR, Betensky RA, et al. An accurate microarray class prediction model for high grade gliomas. Neuro-oncol. 2002;4:345.Google Scholar
- 36.Misra A, Pellarin M, Moore D, et al. A high-resolution genome wide map of genetic aberrations in human astrocytoma. Neuro-oncol. 2002;4:330.Google Scholar
- 37.Brennan C, Kim H, Cauwels C, et al. Identification of candidate genetic alterations from array-CGH in human glioblastomas. Neurooncol. 2002;4:327.Google Scholar