Hematologic Disorders: Hemochromatosis, Hemoglobinopathies, and Rh Incompatibility

  • Daniel B. Bellissimo


Hereditary hemochromatosis (HHC) is an autosomal recessive disorder of iron metabolism resulting from excess iron storage in the liver, skin, pancreas, heart, joints, testes, and pituitary gland. If left untreated, life-threatening complications such as cirrhosis, diabetes, liver cancer, and cardiomyopathy may result. Iron overload and the resulting clinical complications can be avoided by early diagnosis and periodic phlebotomy to reduce the body’s iron stores.


Hereditary Hemochromatosis Locus Control Region H63D Mutation Polymerase Chain Reaction Restriction Fragment Length Polymorphism Maternal Cell Contamination 
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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Daniel B. Bellissimo
    • 1
  1. 1.Molecular Diagnostics LaboratoryBlood Center of Southeastern WisconsinMilwaukeeUSA

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