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Deubiquitinating Activity of the SARS-CoV Papain-Like Protease

  • Naina Barretto
  • Dalia Jukneliene
  • Kiira Ratia
  • Zhongbin Chen
  • Andrew D. Mesecar
  • Susan C. Baker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)

Keywords

Severe Acute Respiratory Syndrome Infectious Bronchitis Virus Severe Acute Respiratory Syndrome Catalytic Cysteine Catalytic Core Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Kim J.C., R.A. Spence, P.F. Currier, X. Lu and M.R. Denison. 1995. Coronavirus protein processing and RNA synthesis is inhibited by the cysteine proteinase inhibitor E64d. Virology 208:1–8.CrossRefPubMedGoogle Scholar
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    Barretto, N., D. Jukneliene, K. Ratia, Z. Chen, A.D. Mesecar and S.C. Baker. The papain-like protease of Severe Acute Respiratory Syndrome (SARS) coronavirus has deubiquitinating activity. J. Virol. 79: 15189–15198.Google Scholar
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    Herold J., S.G. Siddell and A.E. Gorbalenya. 1999. A human RNA viral cysteine proteinase that depends on a unique Zn2+ binding finger connecting the two domains of a papain-like fold. J. Biol. Chem. 274:14918–14925.CrossRefPubMedGoogle Scholar
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    Johnston, S.C., C.N. Larsen, W.J. Cook, K.D. Wilkinson, and C.P. Hill. 1997. Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution. EMBO J. 16:3787–3796.CrossRefPubMedGoogle Scholar
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    Sulea T., H.A. Lindner, E.O. Purisima and R. Menard. 2005. Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain-like protease? J. Virol. 79:4550–4551.CrossRefPubMedGoogle Scholar
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    Hu, M., P.Li, M. Li, W. Li, T. Yao, J.W. Wu, W. Gu, R.E. Cohen and Y. Shi. 2002. Crystal structure of a UBP-family deubiquitinating enzyme in isolation and complex with ubiquitin aldehyde. Cell. 111:1041–1054.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Naina Barretto
    • 1
  • Dalia Jukneliene
    • 2
  • Kiira Ratia
    • 3
  • Zhongbin Chen
    • 4
  • Andrew D. Mesecar
    • 5
  • Susan C. Baker
    • 6
  1. 1.Loyola University Chicago Stritch School of MedicineMaywoodUSA
  2. 2.Loyola University Chicago Stritch School of MedicineMaywoodUSA
  3. 3.Beijing Institute of Radiation MedicineChina
  4. 4.Loyola University Chicago Stritch School of MedicineMaywoodUSA
  5. 5.Beijing Institute of Radiation MedicineChina
  6. 6.Loyola University Chicago Stritch School of MedicineMaywoodUSA

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