A Previously Unrecognized Unr Stem-Loop Structure in the Coronavirus 5’ Untranslated Region Plays a Functional role in Replication

  • Pinghua Liu
  • Jason J. Millership
  • Lichun Li
  • David P. Giedroc
  • Julian L. Leibowitz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 581)


Hairpin Loop Mouse Hepatitis Virus Nuclease Mapping Minimum Free Energy Structure Bovine Coronavirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R.-Y. Chang, M. A. Hofmann, P. B. Sethna, and D. A. Brian, A cis-acting function for the coronavirus leader in defective interfering RNA replication, J. Virol. 68, 8223–8231 (1994).PubMedGoogle Scholar
  2. 2.
    Y. Kim, Y. S. Jeong, and S. Makino, Analysis of cis-acting sequences essential for coronavirus defective interfering RNA replication, Virology 197, 53–63 (1993).CrossRefPubMedGoogle Scholar
  3. 3.
    S. Raman, P. Bouma, G. D. Williams, and D. A. Brian, Stem-loop III in the 5' untranslated region is a cis-acting element in bovine coronavirus defective interfering RNA replication, J. Virol. 77, 6720–6730 (2003).CrossRefPubMedGoogle Scholar
  4. 4.
    I. L. Hofacker, Vienna RNA secondary structure server, Nucleic Acids Res. 31, 3429–3431 (2003).CrossRefPubMedGoogle Scholar
  5. 5.
    B. Yount, M. R. Denison, S. R. Weiss, and R. S. Baric, Systematic assembly of a full-length infectious cDNA of mouse hepatitis virus strain A59, J. Virol. 76, 11065–11078 (2002).CrossRefPubMedGoogle Scholar
  6. 6.
    R. F. Johnson, M. Feng, P. Liu, J. J. Millership, B. Yount, R. S. Baric, and J. L. Leibowitz, The effect of mutations in the mouse hepatitis virus 3'(+)42 protein binding element on RNA replication, J. Virol. (in press).Google Scholar
  7. 7.
    R.-Y. Chang, R. Krishnan, and D. A. Brian, The UCUAAAC promoter motif is not required for high-frequency leader recombination in bovine coronavirus defective interfering RNA, J. Virol. 70, 2720–2729 (1996).PubMedGoogle Scholar
  8. 8.
    R. R. Gutell, J. J. Cannone, D. Konings, and D. Gautheret, Predicting U-turns in ribosomal RNA with comparative sequence analysis, J. Mol. Biol. 300, 791–803 (2000).CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2006

Authors and Affiliations

  • Pinghua Liu
    • 1
  • Jason J. Millership
    • 2
  • Lichun Li
    • 3
  • David P. Giedroc
    • 4
  • Julian L. Leibowitz
    • 5
  1. 1.Texas A&M University System-HCSCollege StationUSA
  2. 2.Texas A&M University System-HCSCollege StationUSA
  3. 3.Texas A&M UniversityCollege StationUSA
  4. 4.Texas A&M UniversityCollege StationUSA
  5. 5.Texas A&M University System-HCSCollege StationUSA

Personalised recommendations