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Molecular Mechanisms of Synaptogenesis pp 125–135Cite as

SynCAM in Formation and Function of Synaptic Specializations

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1. Summary

SynCAM 1 (Synaptic Cell Adhesion Molecule 1), a member of the immunoglobulin (Ig) superfamily of proteins, is an intercellular adhesion molecule at synapses in the central nervous system (CNS). It mediates interactions that bridge the synaptic cleft between pre- and postsynaptic membranes. SynCAM 1 has an active role in synaptic differentiation and induces formation of new presynaptic terminals. In keeping with this activity, SynCAM 1 is expressed throughout the developing brain, indicating a general role in synaptogenesis. SynCAM 1 is a member of a family of four genes found solely in vertebrates. The domain structure of all SynCAM family members is well defined. Three Ig-like domains constitute their extracellular sequence, followed by a single transmembrane region and a short cytosolic tail. Their intracellular sequences display an interaction motif for PDZ domain-containing adaptor molecules and for components of the actin cytoskeleton. These cytosolic protein interaction motifs are highly conserved among all four SynCAM proteins, underscoring their important role in mediating membrane differentiation.

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Author information

Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry, Yale University Medical School, 333 Cedar Street, New Haven, CT, 06520, USA

    Thomas Biederer

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  1. Thomas Biederer
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Editor information

Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Biederer, T. (2006). SynCAM in Formation and Function of Synaptic Specializations. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_9

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