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Mechanisms That Regulate Neuronal Protein Clustering at the Synapse

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Molecular Mechanisms of Synaptogenesis

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1. Summary

There is considerable evidence that synaptic contact formation and remodeling is regulated by assembly of several important classes of proteins, including neurotransmitter receptors, adhesion molecules, and scaffolding proteins. This process is regulated by intricate mechanisms that regulate protein trafficking and clustering at the synapse. In this chapter we discuss some of the newly discovered mechanisms that govern protein targeting to the synapse and how this process contributes to clustering of ion channels and adhesion molecules at contact sites, with emphasis on the role of scaffolding proteins in this process.

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Author information

Authors and Affiliations

  1. University of British Columbia, Vancouver, BC, Canada, V6T 1Z3

    Rochelle M. Hines & Alaa El-Husseini

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  1. Rochelle M. Hines
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  2. Alaa El-Husseini
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Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Hines, R.M., El-Husseini, A. (2006). Mechanisms That Regulate Neuronal Protein Clustering at the Synapse. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_5

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