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Synapse Formation between Identified Molluscan Neurons: A Model System Approach

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Molecular Mechanisms of Synaptogenesis

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1. Summary

From simple reflexes to complex motor patterns and learning and memory, all nervous system functions hinge upon the precise synaptic connectivity that is orchestrated during early development. The synaptogenic program does not stop with the cessation of development, rather it continues well into adulthood, forming the basis for synaptic plasticity that underlies learning and memory. Despite extensive advances in the field of neurodevelopment, the precise cellular and molecular mechanisms of synapse formation between central neurons remain largely unknown, due primarily to the complexity of developing mammalian brain and the rate at which the synaptogenic program proceeds (20,000–30,000synapses/ 10 min). Here we report on the utility of various molluscan models whereby various steps underlying synapse formation can be investigated at the level of individual neurons and synapses. In these models, synaptogenesis can be examined both in vivo during regeneration and following single-cell transplantation, as well as in vitro through a variety of cell culture approaches.

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5. References

  1. Bulloch, A.G., and Syed, N.I. (1992) Trends Neurosci 15, 422–427.

    Article  PubMed  CAS  Google Scholar 

  2. Munno, D.W., and Syed, N.I. (2003) J Physiol 552, 1–11.

    Article  PubMed  CAS  Google Scholar 

  3. Wiersma-Meems, R., Van Minnen, J., and Syed, N.I. (2005) Neuroscientist 11, 228–237.

    Article  PubMed  CAS  Google Scholar 

  4. Haydon, P.G., and Drapeau, P. (1995) Trends Neurosci 18, 196–201.

    Article  PubMed  CAS  Google Scholar 

  5. Ghirardi, M., Casadio, A., Santarelli, L., and Montarolo, P.G. (1996) Invert Neurosci 2, 41–49.

    Article  PubMed  CAS  Google Scholar 

  6. Cibelli, G., Ghirardi, M., Onofri, F., Casadio, A., Benfenati, F., Montarolo, P.G., and Vitiello, F. (1996) Eur J Neurosci 8, 2530–2543.

    Article  PubMed  CAS  Google Scholar 

  7. Moffett, S., and Snyder, K. (1985) J Neurobiol 16, 193–209.

    Article  PubMed  CAS  Google Scholar 

  8. Benjamin, P.R. and. Allison., P. (1987) Growth and Plasticity of Neural Connections (Winlow, W., McCrohan, C.R., Eds.), Manchester University Press, Manchester.

    Google Scholar 

  9. Kruk, P.J., and Bulloch, A.G. (1992) J Neurosci Res 31, 401–412.

    Article  PubMed  CAS  Google Scholar 

  10. Murphy, A.D., and Kater, S.B. (1980) Brain Res 186, 251–272.

    Article  PubMed  CAS  Google Scholar 

  11. Schacher, S., and Proshansky, E. (1983) J Neurosci 3, 2403–2413.

    PubMed  CAS  Google Scholar 

  12. Rayport, S.G., and Schacher, S. (1986) J Neurosci 6, 759–763.

    PubMed  CAS  Google Scholar 

  13. Syed, N.I., Bulloch, A.G., and Lukowiak, K. (1990) Science 250, 282–285.

    Article  PubMed  CAS  Google Scholar 

  14. Spencer, G.E., Lukowiak, K., and Syed, N.I. (2000) J Neurosci 20, 8077–8086.

    PubMed  CAS  Google Scholar 

  15. Wiersma-Meems, R. (2005) Thesis: at Department of Molecular and Cellular Neurobiology, Free University, Amsterdam.

    Google Scholar 

  16. Zoran, M.J., Doyle, R.T., and Haydon, P.G. (1991) Neuron 6, 145–151.

    Article  PubMed  CAS  Google Scholar 

  17. Landis, S.C. (1990) Trends Neurosci 13, 344–350.

    Article  PubMed  CAS  Google Scholar 

  18. Lovell, P., McMahon, B., and Syed, N.I. (2002) J Neurophysiol 88, 1328–1338.

    PubMed  CAS  Google Scholar 

  19. Syed, N.I., Lukowiak, K., and Bulloch, A.G. (1992) Neuroreport 3, 793–796.

    Article  PubMed  CAS  Google Scholar 

  20. Lukowiak, K., Syed, N.I., Ridgway, R.L., and Bulloch, A.G. (1993) Acta Biol Hung 44, 115–119.

    PubMed  CAS  Google Scholar 

  21. Fuchs, P.A., Nicholls, J.G., and Ready, D.F. (1981) J Physiol 316, 203–223.

    PubMed  CAS  Google Scholar 

  22. Fuchs, P.A., Henderson, L.P., and Nicholls, J.G. (1982) J Physiol 323, 195–210.

    PubMed  CAS  Google Scholar 

  23. Haydon, P.G. (1988) J Neurosci 8, 1032–1038.

    PubMed  CAS  Google Scholar 

  24. Feng, Z.P., Klumperman, J., Lukowiak, K., and Syed, N.I. (1997) J Neurosci 17, 7839–7849.

    PubMed  CAS  Google Scholar 

  25. Feng, Z.P., Grigoriev, N., Munno, D., Lukowiak, K., MacVicar, B.A., Goldberg, J.I., and Syed, N.I. (2002) J Physiol 539, 53–65.

    Article  PubMed  CAS  Google Scholar 

  26. Woodall, A.J., Naruo, H., Prince, D.J., Feng, Z.P., Winlow, W., Takasaki, M., and Syed, N.I. (2003) J Neurophysiol 90, 2232–2239.

    Article  PubMed  Google Scholar 

  27. Naruo, H., Onizuka, S., Prince, D., Takasaki, M., and Syed, N.I. (2005) Anesthesiology 102, 920–928.

    Article  PubMed  CAS  Google Scholar 

  28. Hamakawa, T., Woodin, M.A., Bjorgum, M.C., Painter, S.D., Takasaki, M., Lukowiak, K., Nagle, G.T., and Syed, N.I. (1999) J Neurosci 19, 9306–9312.

    PubMed  CAS  Google Scholar 

  29. Woodin, M.A., Hamakawa, T., Takasaki, M., Lukowiak, K., and Syed, N.I. (1999) Learn Mem 6, 307–316.

    PubMed  CAS  Google Scholar 

  30. Woodin, M.A., Munno, D.W., and Syed, N.I. (2002) J Neurosci 22, 505–514.

    PubMed  CAS  Google Scholar 

  31. Fiumara, F., Leitinger, G., Milanese, C., Montarolo, P.G., and Ghirardi, M. (2005) Neuroscience 134, 1133–1151.

    Article  PubMed  CAS  Google Scholar 

  32. Meems, R., Munno, D., van Minnen, J., and Syed, N.I. (2003) J Neurophysiol 89, 2611–2619.

    Article  PubMed  CAS  Google Scholar 

  33. Hermann, P.M., van Kesteren, R.E., Wildering, W.C., Painter, S.D., Reno, J.M., Smith, J.S., Kumar, S.B., Geraerts, W.P., Ericsson, L.H., Smit, A.B., Bulloch, A.G., and Nagle, G.T. (2000) J Neurosci 20, 6355–6364.

    PubMed  CAS  Google Scholar 

  34. Feng, Z.P., Hasan, S.U., Lukowiak, K., and Syed, N.I. (2000) J Neurobiol 42, 357–369.

    Article  PubMed  CAS  Google Scholar 

  35. van Kesteren, R.E., Syed, N.I., Munno, D.W., Bouwman, J., Feng, Z.P., Geraerts, W.P., and Smit, A.B. (2001) J Neurosci 21, RC161.

    Google Scholar 

  36. El-Husseini, A.E., and Vincent, S.R. (1999) J Biol Chem 274, 19771–19777.

    Article  PubMed  CAS  Google Scholar 

  37. van Kesteren, R.E. (personal communication).

    Google Scholar 

  38. Sangha, S., Scheibenstock, A., McComb, C., and Lukowiak, K. (2003) J Exp Biol 206, 1605–1613.

    Article  PubMed  CAS  Google Scholar 

  39. Scheibenstock, A., Krygier, D., Haque, Z., Syed, N.I., and Lukowiak, K. (2002) J Neurophysiol 88, 1584–1591.

    PubMed  Google Scholar 

  40. Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J.C., Chen, M., Bailey, C.H., and Kandel, E.R. (1997) Cell 91, 927–938.

    Article  PubMed  CAS  Google Scholar 

  41. Liu, K., Hu, J.Y., Wang, D., and Schacher, S. (2003) J Neurobiol 56, 275–286.

    Article  PubMed  CAS  Google Scholar 

  42. Fiumara, F., Onofri, F., Benfenati, F., Montarolo, P.G., and Ghirardi, M. (2001) Neuroscience 104, 271–280.

    Article  PubMed  CAS  Google Scholar 

  43. Fiumara, F., Giovedi, S., Menegon, A., Milanese, C., Merlo, D., Montarolo, P.G., Valtorta, F., Benfenati, F., and Ghirardi, M. (2004) J Cell Sci 117, 5145–5154.

    Article  PubMed  CAS  Google Scholar 

  44. Sossin, W.S., Sacktor, T.C., and Schwartz, J.H. (1994) Learn Mem 1, 189–202.

    PubMed  CAS  Google Scholar 

  45. Wu, F., Friedman, L., and Schacher, S. (1995) J Neurosci 15, 7517–7527.

    PubMed  CAS  Google Scholar 

  46. Manseau, F., Sossin, W.S., and Castellucci, V.F. (1998) J Neurophysiol 79, 1210–1218.

    PubMed  CAS  Google Scholar 

  47. Sacktor, T.C., Kruger, K.E., and Schwartz, J.H. (1988) J Physiol (Paris) 83, 224–231.

    Google Scholar 

  48. Purcell, A.L., Sharma, S.K., Bagnall, M.W., Sutton, M.A., and Carew, T.J. (2003) Neuron 37, 473–484.

    Article  PubMed  CAS  Google Scholar 

  49. Sharma, S.K., and Carew, T.J. (2004) Learn Mem 11, 373–378.

    Article  PubMed  Google Scholar 

  50. Martin, K.C., Michael, D., Rose, J.C., Barad, M., Casadio, A., Zhu, H., and Kandel, E.R. (1997) Neuron 18, 899–912.

    Article  PubMed  CAS  Google Scholar 

  51. Turrigiano, G.G., Leslie, K.R., Desai, N.S., Rutherford, L.C., and Nelson, S.B. (1998) Nature 391, 892–896.

    Article  PubMed  CAS  Google Scholar 

  52. Leslie, K.R., Nelson, S.B., and Turrigiano, G.G. (2001) J Neurosci 21, 170.

    Google Scholar 

  53. Casadio, A., Martin, K.C., Giustetto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C.H., and Kandel, E.R. (1999) Cell 99, 221–237.

    Article  PubMed  CAS  Google Scholar 

  54. Munno, D.W., Prince, D.J., and Syed, N.I. (2003) J Neurosci 23, 4146–4155.

    PubMed  CAS  Google Scholar 

  55. Syed, N.I., Ridgway, R.L., Lukowiak, K., and Bulloch, A.G. (1992) Neuron 8, 767–774.

    Article  PubMed  CAS  Google Scholar 

  56. Lee, T.K., and Syed, N.I. (2004) Synapse 51, 186–193.

    Article  PubMed  CAS  Google Scholar 

  57. Li, K.W. et al. (2004) J Biol Chem 279, 987–1002.

    Article  PubMed  CAS  Google Scholar 

  58. Jimenez, C.R., Stam, F.J., Li, K.W., Gouwenberg, Y., Hornshaw, M.P., De Winter, F., Verhaagen, J., and Smit, A.B. (2005) Mol Cell Proteomics 4, 120–132.

    Article  PubMed  CAS  Google Scholar 

  59. Jimenez, C., Spijker, S., de Schipper, S., Lodder, J.C., Janse, C., Geraerts, W.P.M., van Minnen, J., Syed, N.I., Burlingame, A.L., Smit, A.B., and Li, K.W. (2006) J Neurosci 26, 518–529.

    Article  PubMed  CAS  Google Scholar 

  60. Merz, M. (2004) Thesis at Max-Planck Institute for Biochemistry, Technical University Munchen, Munchen.

    Google Scholar 

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Author information

Authors and Affiliations

  1. University of Calgary, Calgary, AB, T2N 1N4, Canada

    Ryanne Wiersma-Meems

  2. Departments of Anatomy and Physiology, Health Sciences Center, 3330 Hospital Dr. N.W., Calgary, AB, Canada, T2N 4N1

    Naweed I. Syed

Authors
  1. Ryanne Wiersma-Meems
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  2. Naweed I. Syed
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Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Wiersma-Meems, R., Syed, N.I. (2006). Synapse Formation between Identified Molluscan Neurons: A Model System Approach. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_3

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