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Ephrins and Eph Receptors in Spinogenesis and Synaptic Plasticity

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Molecular Mechanisms of Synaptogenesis

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1. Summary

Originally identified as repulsive axon guidance cues, Eph receptors and their cell surface-bound ligands ephrins have been increasingly implicated in the development and functional modulation of synapses. Two synaptic functions of ephrins and Eph receptors have now been well established by in vitro and in vivo studies, namely the induction and maintenance of dendritic spines and the regulation of synaptic plasticity. This chapter summarizes recent progress in this rapidly expanding area of ephrin-Eph research. An emerging view is that Eph receptors regulate spine morphology by activating multiple intracellular signaling cascades that involve Rho family GTPases. In contrast, genetic studies suggest that regulation of synaptic plasticity does not require extensive intracellular signaling.

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8. References

  1. Flanagan, J.G., and Vanderhaeghen, P. (1998) Annu Rev Neurosci 21, 309–345.

    Article  PubMed  CAS  Google Scholar 

  2. Kullander, K., and Klein, R. (2002) Nat Rev Mol Cell Biol 3, 475–486.

    Article  PubMed  CAS  Google Scholar 

  3. Pasquale, E.B. (2005) Nat Rev Mol Cell Biol 6, 462–475.

    Article  PubMed  CAS  Google Scholar 

  4. Kalo, M.S., and Pasquale, E.B. (1999) Biochemistry 38, 14396–14408.

    Article  PubMed  CAS  Google Scholar 

  5. Kalo, M.S., Yu, H.H., and Pasquale, E.B. (2001) J Biol Chem 276, 38940–38948.

    Article  PubMed  CAS  Google Scholar 

  6. Torres, R., Firestein, B.L., Dong, H., Staudinger, J., Olson, E.N., Huganir, R.L., Bredt, D.S., Gale, N.W., and Yancopoulos, G.D. (1998) Neuron 21, 1453–1463.

    Article  PubMed  CAS  Google Scholar 

  7. Buchert, M., Schneider, S., Meskenaite, V., Adams, M.T., Canaani, E., Baechi, T., Moelling, K., and Hovens, C.M. (1999) J Cell Biol 144, 361–371.

    Article  PubMed  CAS  Google Scholar 

  8. Shamah, S.M., Lin, M.Z., Goldberg, J.L., Estrach, S., Sahin, M., Hu, L., Bazalakova, M., Neve, R.L., Corfas, G., Debant, A., and Greenberg, M.E. (2001) Cell 105, 233–244.

    Article  PubMed  CAS  Google Scholar 

  9. Irie, F., and Yamaguchi, Y. (2002) Nat Neurosci 5, 1117–1118.

    Article  PubMed  CAS  Google Scholar 

  10. Tanaka, M., Ohashi, R., Nakamura, R., Shinmura, K., Kamo, T., Sakai, R., and Sugimura, H. (2004) EMBO J 23, 1075–1088.

    Article  PubMed  CAS  Google Scholar 

  11. Cowan, C.A., and Henkemeyer, M. (2002) Trends Cell Biol 12, 339–346.

    Article  PubMed  CAS  Google Scholar 

  12. Cowan, C.A., and Henkemeyer, M. (2001) Nature 413, 174–179.

    Article  PubMed  CAS  Google Scholar 

  13. Palmer, A., Zimmer, M., Erdmann, K.S., Eulenburg, V., Porthin, A., Heumann, R., Deutsch, U., and Klein, R. (2002) Mol Cell 9, 725–737.

    Article  PubMed  CAS  Google Scholar 

  14. Lu, Q., Sun, E.E., Klein, R.S., and Flanagan, J.G. (2001) Cell 105, 69–79.

    Article  PubMed  CAS  Google Scholar 

  15. Yamaguchi, Y., and Pasquale, E.B. (2004) Curr Opin Neurobiol 14, 288–296.

    Article  PubMed  CAS  Google Scholar 

  16. Grunwald, I.C., Korte, M., Adelmann, G., Plueck, A., Kullander, K., Adams, R.H., Frotscher, M., Bonhoeffer, T., and Klein, R. (2004) Nat Neurosci 7, 33–40.

    Article  PubMed  CAS  Google Scholar 

  17. Henderson, J.T., Georgiou, J., Jia, Z.P., Robertson, J., Elowe, S., Roder, J.C., and Pawson, T. (2001) Neuron 32, 1041–1056.

    Article  PubMed  CAS  Google Scholar 

  18. Henkemeyer, M., Itkis, O.S., Ngo, M., Hickmott, P.W., and Ethell, I.M. (2003) J Cell Biol 163, 1313–1326.

    Article  PubMed  CAS  Google Scholar 

  19. Murai, K.K., Nguyen, L.N., Irie, F., Yamaguchi, Y., and Pasquale, E.B. (2003) Nat Neurosci 6, 153–160.

    Article  PubMed  CAS  Google Scholar 

  20. Ethell, I.M., Irie, F., Kalo, M.S., Couchman, J.R., Pasquale, E.B., and Yamaguchi, Y. (2001) Neuron 31, 1001–1013.

    Article  PubMed  CAS  Google Scholar 

  21. Penzes, P., Beeser, A., Chernoff, J., Schiller, M.R., Eipper, B.A., Mains, R.E., and Huganir, R.L. (2003) Neuron 37, 263–274.

    Article  PubMed  CAS  Google Scholar 

  22. Vesce, S., Bezzi, P., and Volterra, A. (1999) Cell Mol Life Sci 56, 991–1000.

    Article  PubMed  CAS  Google Scholar 

  23. Gao, W.Q., Shinsky, N., Armanini, M.P., Moran, P., Zheng, J.L., Mendoza-Ramirez, J.L., Phillips, H.S., Winslow, J.W., and Caras, I.W. (1998) Mol Cell Neurosci 11, 247–259.

    Article  PubMed  CAS  Google Scholar 

  24. Gerlai, R., Shinsky, N., Shih, A., Williams, P., Winer, J., Armanini, M., Cairns, B., Winslow, J., Gao, W., and Phillips, H.S. (1999) J Neurosci 19, 9538–9549.

    PubMed  CAS  Google Scholar 

  25. Gerlai, R., and McNamara, A. (2000) Behav Brain Res 108, 133–143.

    Article  PubMed  CAS  Google Scholar 

  26. Grunwald, I.C., Korte, M., Wolfer, D., Wilkinson, G.A., Unsicker, K., Lipp, H.P., Bonhoeffer, T., and Klein, D. (2001) Neuron 32, 1027–1040.

    Article  PubMed  CAS  Google Scholar 

  27. Dalva, M.B., Takasu, M.A., Lin, M.Z., Shamah, S.M., Hu, L., Gale, N.W., and Greenberg, M.E. (2000) Cell 103, 945–956.

    Article  PubMed  CAS  Google Scholar 

  28. Contractor, A., Rogers, C., Maron, C., Henkemeyer, M., Swanson, G.T., and Heinemann, S.F. (2002) Science 296, 1864–1869.

    Article  PubMed  CAS  Google Scholar 

  29. Fukata, Y., Tzingounis, A.V., Trinidad, J.C., Fukata, M., Burlingame, A.L., Nicoll, R.A., and Bredt, D.S. (2005) J Cell Biol 169, 399–404.

    Article  PubMed  CAS  Google Scholar 

  30. Hoogenraad, C.C., Milstein, A.D., Ethell, I.M., Henkemeyer, M., and Sheng, M. (2005) Nat Neurosci 8, 906–915.

    PubMed  CAS  Google Scholar 

  31. Ji, R.R., Kohno, T., Moore, K.A., and Woolf, C.J. (2003) Trends Neurosci 26, 696–705.

    Article  PubMed  CAS  Google Scholar 

  32. Battaglia, A.A., Sehayek, K., Grist, J., McMahon, S.B., and Gavazzi, I. (2003) Nat Neurosci 6, 339–340.

    Article  PubMed  CAS  Google Scholar 

  33. Landis, D.M., and Reese, T.S. (1983) J Cell Biol 97, 1169–1178.

    Article  PubMed  CAS  Google Scholar 

  34. Matus, A. (2000) Science 290, 754–758.

    Article  PubMed  CAS  Google Scholar 

  35. Bonhoeffer, T., and Yuste, R. (2002) Neuron 35, 1019–1027

    Article  PubMed  CAS  Google Scholar 

  36. Govek, E.E., Newey, S.E., and Van Aelst, L. (2005) Genes Dev 19, 1–49.

    Article  PubMed  CAS  Google Scholar 

  37. Luo, L., Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996) Nature 379, 837–840.

    Article  PubMed  CAS  Google Scholar 

  38. Nakayama, A.Y, Harms, M.B., and Luo, L. (2000) J Neurosci 20, 5329–5338.

    PubMed  CAS  Google Scholar 

  39. Scott, E.K., Reuter, J.E., and Luo, L. (2003) J Neurosci 23, 3118–3123.

    PubMed  CAS  Google Scholar 

  40. Ishikawa, Y., Katoh, H., and Negishi, M. (2003) J Neurosci 23, 11065–11072.

    PubMed  CAS  Google Scholar 

  41. Hering, H., and Sheng, M. (2003) J Neurosci 23, 11759–11769.

    PubMed  CAS  Google Scholar 

  42. Ma, X.M., Huang, J., Wang, Y., Eipper, B.A., and Mains, R.E. (2003) J Neurosci 23, 10593–10603.

    PubMed  CAS  Google Scholar 

  43. Takasu, M.A., Dalva, M.B., Zigmond, R.E., and Greenberg, M.E. (2002) Science 295, 491–495.

    Article  PubMed  CAS  Google Scholar 

  44. Irie, F., Okuno, M., Pasquale, E.B., and Yamaguchi, Y. (2005) Nat Cell Biol 7, 501–509.

    Article  PubMed  CAS  Google Scholar 

  45. Ethell, I.M., and Yamaguchi, Y. (1999) J Cell Biol 144, 575–586.

    Article  PubMed  CAS  Google Scholar 

  46. Krause, M., Dent, E.W., Bear, J.E., Loureiro, J.J., and Gertler, F.B. (2003) Annu Rev Cell Dev Biol 19, 541–564.

    Article  PubMed  CAS  Google Scholar 

  47. Li, W., Li, Y., and Gao, F.B. (2005) Dev Dyn 234, 512–522.

    Article  PubMed  CAS  Google Scholar 

  48. Cowan, C.W., Shao, Y.R., Sahin, M., Shamah, S.M., Lin, M.Z., Greer, P.L., Gao, S., Griffith, E.C., Brugge, J.S., and Greenberg, M.E. (2005) Neuron 46, 205–217.

    Article  PubMed  CAS  Google Scholar 

  49. Malinow, R., and Malenka, R.C. (2002) Annu Res Neurosci 25, 103–126.

    Article  CAS  Google Scholar 

  50. Bredt, D.S., and Nicoll, R.A. (2003) Neuron 40, 361–379.

    Article  PubMed  CAS  Google Scholar 

  51. Marston, D.J., Dickinson, S., and Nobes, C.D. (2003) Nat Cell Biol 5, 879–888.

    Article  PubMed  CAS  Google Scholar 

  52. Zimmer, M., Palmer, A., Kohler, J., and Klein, R. (2003) Nat Cell Biol 5, 869–878.

    Article  PubMed  CAS  Google Scholar 

  53. McPherson, P.S., Garcia, E.P., Slepnev, V.I., David, C., Zhang, X., Grabs, D., Sossin, W.S., Bauerfeind, R., Nemoto, Y., and De Camilli, P. (1996) Nature 379, 353–357.

    Article  PubMed  CAS  Google Scholar 

  54. Slepnev, V.I., and De Camilli, P. (2000) Nat Rev Neurosci 1, 161–172.

    Article  PubMed  CAS  Google Scholar 

  55. Man, H.Y., Lin, J.W., Ju, W.H., Ahmadian, G., Liu, L., Becker, L.E., Sheng, M., Wang, Y.T. (2000) Neuron 25, 649–662.

    Article  PubMed  CAS  Google Scholar 

  56. Lee, S.H., Liu, L., Wang, Y.T., and Sheng, M. (2002) Neuron 36, 661–674.

    Article  PubMed  CAS  Google Scholar 

  57. Cottrell, J.R., Borok, E., Horvath, T.L. and Nedivi, E. (2004) Neuron 44, 677–690.

    PubMed  CAS  Google Scholar 

  58. Cooney, J.R., Hurlburt, J.L., Selig, D.K., Harris, K.M. and Fiala, J.C. (2002) J Neurosci 22, 2215–2224.

    PubMed  CAS  Google Scholar 

  59. Maxfield, F.R., and McGrow, T.E. (2004) Nat Rev Mol Cell Biol 5, 121–132.

    Article  PubMed  CAS  Google Scholar 

  60. Rudelli, R.D, Brown, W.T., Wisniewski, K., Jenkins, E.C., Laure-Kaminowska, M., Connell F., and Wisniewski, H.M. (1985) Acta Neuropathol (Berl) 67, 289–295.

    Article  CAS  Google Scholar 

  61. Hinton, V.J, Brown, W.T., Wisniewski, K., and Rudelli, R.D. (1991) Am J Med Genet 41, 289–294.

    Article  PubMed  CAS  Google Scholar 

  62. Glantz, L.A., and Lewis, D.A. (2000) Arch Gen Psychiatry 57, 65–73.

    Article  PubMed  CAS  Google Scholar 

  63. Kaufmann, W.E., and Moser, H.W. (2000) Cerebral Cortex 10, 981–991.

    Article  PubMed  CAS  Google Scholar 

  64. Goff, D.C., and Coyle, J.T. (2001) Am J Psychiatry 158, 1367–1377.

    Article  PubMed  CAS  Google Scholar 

  65. Purcell, A.E., Jeon, O.H., Zimmerman, A.W., Blue, M.E., and Pevsner, J. (2001) Neurology 57, 1618–1628.

    PubMed  CAS  Google Scholar 

  66. Yue, Y., Widmer, D.A.J., Halladay, A.K., Ceretti, D.P., Wagner, G.C., Dreyer, J.-L., and Zhou, R. (1999) J Neurosci 19, 2090–2101.

    PubMed  CAS  Google Scholar 

  67. Halladay, A.K., Yue, Y., Michna, L., Widmer, D.A.J., Wagner, G.C., and Zhou, R. (2000) Mol Brain Res 85, 171–178.

    Article  PubMed  CAS  Google Scholar 

  68. Nestler, E.J. (2001) Nat Rev Neurosci 2, 119–128.

    Article  PubMed  CAS  Google Scholar 

  69. Robinson, T.E., and Kolb, B. (2004) Neuropharmacology 47,Suppl 1, 33–46.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Developmental Neurobiology Program, Burnham Institute for Medical Research, La Jolla, CA, USA

    Yu Yamaguchi & Fumitoshi Irie

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  1. Yu Yamaguchi
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  2. Fumitoshi Irie
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Editors and Affiliations

  1. University Medical Center Hamburg-Eppendorf, 52 Martinistrasse, Hamburg, 20246, Germany

    Alexander Dityatev

  2. University of British Columbia, 2255 Wesbrook Mall, Vancouver, British Columbia, Canada, V6T 2A1

    Alaa El-Husseini

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Yamaguchi, Y., Irie, F. (2006). Ephrins and Eph Receptors in Spinogenesis and Synaptic Plasticity. In: Dityatev, A., El-Husseini, A. (eds) Molecular Mechanisms of Synaptogenesis. Springer, Boston, MA . https://doi.org/10.1007/978-0-387-32562-0_11

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