Skip to main content
  • 1157 Accesses

Abstract

The practitioner of pediatric nuclear medicine should have some knowledge of radiation effects and the potential hazards that may result from low-level radiation exposures. There are several reasons such information is essential. First, specialists should ensure that the exposure of patients to radiation from diagnostic or therapeutic procedures is not excessive. Although all current radiopharmaceuticals deliver radiation doses within a readily acceptable range, such was not the case 30 years ago when the radionuclides employed were generally longer-lived and emitted significant particulate radiation, e.g., iodine-131, strontium 87. As a result, before 1970 at Children’s Hospital Boston, radionuclides were administered only to patients with advanced neoplastic diseases. Today, as new agents are introduced, it is imperative to understand the kinetics of their distribution and the resulting radiation doses delivered to various organs. Moreover, for those who participate in clinical trials, an estimation of the absorbed radiation dose is required by institutional review boards, as is some assessment of the potential hazard.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 209.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rothkamm K, Löbrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci USA 2003;100:5057–62.

    Article  PubMed  CAS  Google Scholar 

  2. Dale RG. Dose-rate effects in targeted radiotherapy. Phys Med Biol 1996;41:1871–84.

    Article  PubMed  CAS  Google Scholar 

  3. National Council on Radiation Protection and Measurements. Evaluation of the linearnonthreshold dose-response model for ionizing radiation. NCRP Report No. 136. Bethesda,MD: National Council on Radiation Protection and Measurements, 2001.

    Google Scholar 

  4. Ullrich RL, Storer JB. Influence of γ irradiation on the development of neoplastic disease in mice. III. Dose-rate effects. Radiat Res 1979;80: 325–42.

    Article  PubMed  CAS  Google Scholar 

  5. United Nations Scientific Committee on the Effects of Atomic Radiation. Hereditary effects of radiation, UNSCEAR 2001 Report to the General Assembly with scientific annex. New York: United Nations, 2001.

    Google Scholar 

  6. Asakawa J, Kuick R, Kodaira M, et al. A genome scanning approach to assess the genetic effects of radiation in mice and humans. Radiat Res 2004;161:380–90.

    Article  PubMed  CAS  Google Scholar 

  7. United Nations Scientific Committee on the Effects of Atomic Radiation. Sources and effects of ionizing radiations. UNSCEAR 2000 Report to the General Assembly with scientific annexes, vol. II: effects. New York: United Nations, 2000.

    Google Scholar 

  8. Preston DL, Shimizu Y, Pierce DA, et al. Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950-1997. Radiat Res 2003;160:381–407.

    Article  PubMed  CAS  Google Scholar 

  9. Brenner DJ. Estimating cancer risks from pediatric CT: going from the qualitative to the quantitative. Pediatr Radiol 2002;32:228–31.

    Article  PubMed  Google Scholar 

  10. Fagin JA. Editorial: challenging dogma in thyroid cancer molecular genetics-role of RET/PTC and BRAF in tumor initiation. J Clin Endocrinol Metab 2004;89:4264–6.

    Article  PubMed  CAS  Google Scholar 

  11. Schull WJ, Otake M. Cognitive function and prenatal exposure to ionizing radiation. Teratology 1999;59:222–6.

    Article  PubMed  CAS  Google Scholar 

  12. Adelstein SJ. Administered radionuclides in pregnancy. Teratology 1999;59:236–9.

    Article  PubMed  CAS  Google Scholar 

  13. Brenner DJ, Doll R, Goodhead DT, et al. Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc Natl Acad Sci USA 2003;100:13761–6.

    Article  PubMed  CAS  Google Scholar 

  14. Ishii K, Hosoi Y, Yamada S, et al. Decreased incidence of thymic lymphoma in AKR mice as a result of chronic, fractionated low-dose total-body X irradiation. Radiat Res 1996;146: 582–5.

    Article  PubMed  CAS  Google Scholar 

  15. Johansson L. Hormesis: an update of the present position. Eur J Nucl Med Mol Imaging 2003; 30:921–33.

    Article  PubMed  Google Scholar 

  16. Mitchell SA, Marino SA, Brenner DJ, et al. Bystander effect and adaptive response in C3H 10T1/2 cells. Int J Radiat Biol 2004;80: 465–72.

    Article  PubMed  CAS  Google Scholar 

  17. Adelstein SJ. Uncertainty and relative risks of radiation exposure. JAMA 1987;258:655–7.

    Article  PubMed  CAS  Google Scholar 

  18. Sankaranarayanan K. Estimation of the hereditary risks of exposure to ionizing radiation: history, current status, and emerging perspectives. Health Phys 2001;80:363–9.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

James Adelstein, S. (2007). Radiation Risk. In: Treves, S.T. (eds) Pediatric Nuclear Medicine/PET. Springer, New York, NY. https://doi.org/10.1007/978-0-387-32322-0_19

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-32322-0_19

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-0-387-32321-3

  • Online ISBN: 978-0-387-32322-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics