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Leptin pp 79–101Cite as

Leptin-Insulin Interrelationships

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Part of the book series: Endocrine Updates ((ENDO,volume 25))

Abstract

The relationship of leptin to insulin is complex and our understanding of the interaction is evolving. Leptin is secreted from white adipocytes and levels correlate with adipose tissue mass. Via hypothalamic leptin receptors (ObR), it restricts food intake and increases energy expenditure in normal individuals. Leptin is implicated in decreased production and secretion of insulin by the pancreatic beta (β) cell. Insulin, conversely, stimulates leptin secretion in an adipocyte-insulin feedback loop. The studies available to date, however, have had varying results as to whether leptin is an antidiabetogenic protein. This chapter will delineate the relationships on leptin secretion and action.

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Authors and Affiliations

  1. Medstar Research Institute, Washington, DC

    Asha Thomas-Geevarghese & Robert Ratner

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  1. Asha Thomas-Geevarghese
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  2. Robert Ratner
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Editors and Affiliations

  1. Texas Tech University School of Medicine, Lubbock, Texas, USA

    V. Daniel Castracane PhD (Professor Emeritus and Director of Laboratory Operations) (Professor Emeritus and Director of Laboratory Operations)

  2. Foundation for Blood Research, P. O. Box 190, Scarborough, ME, USA

    V. Daniel Castracane PhD (Professor Emeritus and Director of Laboratory Operations) (Professor Emeritus and Director of Laboratory Operations)

  3. Department of Biological Sciences, Purdue University Calumet, Hammond, Indiana, USA

    Michael C. Henson PhD (Professor and Head) (Professor and Head)

  4. Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, LA, USA

    Michael C. Henson PhD (Professor and Head) (Professor and Head)

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Thomas-Geevarghese, A., Ratner, R. (2006). Leptin-Insulin Interrelationships. In: Castracane, V.D., Henson, M.C. (eds) Leptin. Endocrine Updates, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-31416-7_5

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  • DOI: https://doi.org/10.1007/978-0-387-31416-7_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-31415-0

  • Online ISBN: 978-0-387-31416-7

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