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Leptin pp 327–359Cite as

Clinical Applications of Leptin

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Part of the book series: Endocrine Updates ((ENDO,volume 25))

Abstract:

The discovery of the adipocyte hormone leptin has had a profound impact on our understanding of obesity and the role of the adipose tissue as an endocrine organ. Due primarily to the weight reducing effect of leptin in the ob/ob mouse, the initial enthusiasm for leptin clinical investigation was in human obesity. This review will trace the clinical studies from states of leptin deficiency (‘itOb/Ob’, lipodystrophy, hypothalamic amenorrhea), a physiological replacement paradigm, to the pharmacological applications in obesity (a purported state of leptin insensitivity). This chapter reviews the clinical applications of two leptin analogs for which there is relevant clinical data available (A-200, a long acting analog, will not be discussed, as there is little available data). Both animal and clinical data in multiple disease states provide strong support for a leptin analogue as a potent physiological replacement therapy in states of ‘leptin deficiency’. The pharmacological applications in obesity will require further work to identify populations that might respond to leptin alone or in combination with agents impacting other pathways. The available clinical studies provide invaluable insights into furthering our understanding of the relevance of this hormone in health and disease states. Future studies are needed to explore the many potential applications of this remarkable cytokine hormone.

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  1. Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI

    Elif Ariogly Oral

  2. Amgen Inc., Thousand Oaks, CA

    Alex M. DePaoli

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  1. Texas Tech University School of Medicine, Lubbock, Texas, USA

    V. Daniel Castracane PhD (Professor Emeritus and Director of Laboratory Operations) (Professor Emeritus and Director of Laboratory Operations)

  2. Foundation for Blood Research, P. O. Box 190, Scarborough, ME, USA

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  3. Department of Biological Sciences, Purdue University Calumet, Hammond, Indiana, USA

    Michael C. Henson PhD (Professor and Head) (Professor and Head)

  4. Dept. of Obstetrics and Gynecology, School of Medicine, Tulane University Health Sciences, New Orleans, LA, USA

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Oral, E.A., DePaoli, A.M. (2006). Clinical Applications of Leptin. In: Castracane, V.D., Henson, M.C. (eds) Leptin. Endocrine Updates, vol 25. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-31416-7_17

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