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Lupus Glomerulonephritis

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Fundamentals of Renal Pathology

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Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown cause that can occur at almost any age, although it affects mostly women in their 20s. The annual incidence of SLE is 50 to 70 people per million of the population, and prevalence is 500 per million (1). Epidemiologic data show that the incidence of new cases and the survival of patients with SLE are both increasing (2). The disease is characterized by a large variety of organ disorders involving many different immune mechanisms. This is reflected in particular by the spectrum of glomerular lesions, resulting in a strong variation of the clinical symptoms of the renal disease. Clinical or morphologic involvement of the kidney in SLE occurs in 50% to 80% of lupus patients at any moment during the course of their disease. Moreover, renal alterations are found in almost 90% of lupus patients at autopsy. The lowest 5-year survival has been reported for patients with central nervous system and renal involvement (1).

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  1. Jan A. Bruijn
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Editors and Affiliations

  1. Vanderbilt University Medical Center, Nashville, TN, USA

    Agnes B. Fogo M.D.

  2. Cedars-Sinai Medical Center, UCLA School of Medicine, Los Angeles, CA, USA

    Arthur H. Cohen M.D.

  3. University of North Carolina, Chapel Hill, NC, USA

    J. Charles Jennette M.D.

  4. Leiden University Medical Center, Leiden, the Netherlands

    Jan A. Bruijn M.D., Ph.D.

  5. Massachusetts General Hospital, Boston, MA, USA

    Robert B. Colvin M.D.

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Bruijn, J.A. (2006). Lupus Glomerulonephritis. In: Fogo, A.B., Cohen, A.H., Jennette, J.C., Bruijn, J.A., Colvin, R.B. (eds) Fundamentals of Renal Pathology. Springer, New York, NY. https://doi.org/10.1007/978-0-387-31127-2_8

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