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Innovative Treatment Strategies for High-Grade Gliomas

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Tumors of the Brain and Spine

Part of the book series: M. D. Anderson Cancer Care Series ((MDCCS))

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References

  • Archer GE, Bigner DD, Friedman AH, Heimberger AB, Sampson J. Induction of CD4 and CD8 T cells to the tumor-specific antigen EGFRvIII. 15th International Conference on Brain Tumor Research and Therapy. Sorrento, Italy. May 24–27, 2003. [Abstract] Neuro-Oncology 2003;5:5.

    Google Scholar 

  • Bloom HJ, Peckham MJ, Richardson AE, Alexander PA, Payne PM. Glioblastoma multiforme: a controlled trial to assess the value of specific active immunotherapy in patients treated by radical surgery and radiotherapy. Br J Cancer 1973;27: 253–267.

    PubMed  CAS  Google Scholar 

  • Brooks WH, Markesbery WR, Gupta GD, Roszman TL. Relationship of lymphocyte invasion and survival of brain tumor patients. Ann Neurol 1978;4:219–224.

    Article  PubMed  CAS  Google Scholar 

  • Cserr HF, DePasquale M, Harling-Berg CJ, Park JT, Knopf PM. Afferent and efferent arms of the humoral immune response to CSF-administered albumins in a rat model with normal blood-brain barrier permeability. J Neuroimmunol 1992; 41:195–202.

    Article  PubMed  CAS  Google Scholar 

  • Dresemann G. Temozolomide/pegylated liposomal doxorubicin (PLD) in progressive glioblastoma multiforme (GBM). In: Abstracts from the World Federation of Neuro-Oncology Second Quadrennial Meeting and the Sixth Meeting of the European Association for Neuro-Oncology. May 5–8, 2005. Edinburgh, United Kingdom. [Abstract 112] Society of Neuro-Oncology, 2005:310.

    Google Scholar 

  • Fecci PE, Mitchell DA, Whitesides JF, et al. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res 2006;66:3294–3302.

    Article  PubMed  CAS  Google Scholar 

  • Folkman J. Tumor angiogenesis. [Review] Adv Cancer Res 1974;19:331–358.

    Article  PubMed  CAS  Google Scholar 

  • Folkman J. From the lab to the clinic: one investigator's journey. J Law Med Ethics 2002;30:361–366.

    Article  PubMed  Google Scholar 

  • Folkman J. Fundamental concepts of the angiogenic process. [Review] Curr Mol Med 2003;3:643–651.

    Article  PubMed  CAS  Google Scholar 

  • Goudar R, Shi Q, Hjelmeland M, et al. Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. Mol Cancer Ther 2005;4:101–112.

    PubMed  CAS  Google Scholar 

  • Groves M, Puduvalli V, Conrad CA, et al. Matrix metalloproteinase inhibitor-induced joint-related toxicity predicts prolonged progression-free survival in recurrent high-grade glioma trials. In: Abstracts from the World Federation of Neuro-Oncology Second Quadrennial Meeting and the Sixth Meeting of the European Association for Neuro-Oncology. May 5–8, 2005. Edinburgh, United Kingdom. [Abstract 143] Society of Neuro-Oncology, 2005:318.

    Google Scholar 

  • Groves M, Puduvalli V, Hess K, et al. Phase II trial of temozolomide plus the matrix metalloproteinase inhibitor, marimastat, in recurrent and progressive glioblastoma multiforme. J Clin Oncol 2002;20:1383–1388.

    Article  PubMed  CAS  Google Scholar 

  • Hanahan D, Weinberg R. The hallmarks of cancer. Cell 2000;100:57–70.

    Article  PubMed  CAS  Google Scholar 

  • Heimberger A, Hlatky R, Suki D, et al. Prognostic effect of epidermal growth factor receptor and EGFRvIII in glioblastoma multiforme patients. Clin Cancer Res 2005;11:1462–1466.

    Article  PubMed  CAS  Google Scholar 

  • Heimberger AB, Crotty LE, Archer GE, et al. Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. Clin Cancer Res 2003;9:4247–4254.

    PubMed  CAS  Google Scholar 

  • Hickey WF, Hsu BL, Kimura H. T-lymphocyte entry into the central nervous system. J Neurosci Res 1991;28:254–260.

    Article  PubMed  CAS  Google Scholar 

  • Hussain SF, Yang D, Suki D, Aldape K, Grimm E, Heimberger AB. The role of human glioma-infiltrating microglia/macrophages in mediating antitumor immune responses. Neuro-Oncology 2006;8:261–279.

    Article  PubMed  CAS  Google Scholar 

  • Kleiheus P, Burger P, Plate K, Ohgaki H, Cavenee W. Astrocytic tumors. In: Kleihues P, Cavenee W, eds. Pathology and Genetics: Tumors of the Nervous System. Vol. 1. Lyon, France: International Agency for Research on Cancer; 1997.

    Google Scholar 

  • Kunwar S. Convection enhanced delivery of IL13-PE38QQR for treatment of recurrent malignant glioma: presentation of interim findings from ongoing phase 1 studies. Acta Neurochir Suppl 2003;88:105–111.

    PubMed  CAS  Google Scholar 

  • Kurpad SN, Zhao XG, Wikstrand CJ, Batra SK, McLendon RE, Bigner DD. Tumor antigens in astrocytic gliomas. [Review] Glia 1995;15:244–256.

    Article  PubMed  CAS  Google Scholar 

  • Levin V, Silver P, Hannigan J, et al. Superiority of post-radiotherapy adjuvant chemotherapy with CCNU, procarbazine, and vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 1990;18:321–324.

    PubMed  CAS  Google Scholar 

  • Lu Y, Wang H, Mills G. Targeting PI3K-AKT pathway for cancer therapy. Rev Clin Exp Hematol 2003;7:205–228.

    PubMed  CAS  Google Scholar 

  • McCarthy B, Surawicz T, Bruner J, Kruchko C, Davis F. Consensus Conference on Brain Tumor Definition for registration. Neuro-oncology 2002;4:134–145.

    Article  PubMed  Google Scholar 

  • Palma L, Di Lorenzo N, Guidetti B. Lymphocytic infiltrates in primary glioblastomas and recidivous gliomas. Incidence, fate, and relevance to prognosis in 228 operated cases. J Neurosurg 1978;49:854–861.

    Article  PubMed  CAS  Google Scholar 

  • Plautz G, Miller D, Barnett G, et al. T cell adoptive immunotherapy of newly diagnosed gliomas. Clin Cancer Res 2000;6:2209–2218.

    PubMed  CAS  Google Scholar 

  • Prados M, Levin V. Biology and treatment of malignant glioma. Semin Oncol 2000;27:1–10.

    PubMed  CAS  Google Scholar 

  • Rasheed BK, Wiltshire RN, Bigner SH, Bigner DD. Molecular pathogenesis of malignant gliomas. [Review] Curr Opin Oncol 1999;11:162–167.

    Article  PubMed  CAS  Google Scholar 

  • Reardon DA, Akabani G, Coleman RE, et al. Phase II trial of murine 131I-labeled antitenascin monoclonal antibody 81C6 administered into surgically created resection cavities of patients with newly diagnosed malignant gliomas. J Clin Oncol 2002;20:1389–1397.

    Article  PubMed  CAS  Google Scholar 

  • Safdari H, Hochberg F, Richardson E. Prognostic value of round cell (lymphocyte) infiltration in malignant gliomas. Surg Neurol 1985;23:221–226.

    Article  PubMed  CAS  Google Scholar 

  • Salazar A, Levy H, Ondra S, et al. Long-term treatment of malignant gliomas with intramuscularly administered polyinosinic-polycytidylic acid stabilized with polylysine and carboxymethylcellulose: an open pilot study. Neurosurgery 1996;38:1096–1103; Discussion 1103–1104.

    Article  PubMed  CAS  Google Scholar 

  • Sampson JH, Crotty LE, Lee S, et al. Unarmed, tumor-specific monoclonal antibody effectively treats brain tumors. Proc Natl Acad Sci U S A 2000;97: 7503–7508.

    Article  PubMed  CAS  Google Scholar 

  • Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356–362.

    Article  PubMed  CAS  Google Scholar 

  • Stupp R, Mason W, van den Bent M, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 2005;352:987–996.

    Article  PubMed  CAS  Google Scholar 

  • Talapatra S, Thompson C. Growth factor signaling in cell survival: implications for cancer treatment. J Pharmacol Exp Ther 2001;298:873–878.

    PubMed  CAS  Google Scholar 

  • Traxler P, Allegrini P, Brandt RM, et al. AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. Cancer Res 2004;64:4931–4941.

    Article  PubMed  CAS  Google Scholar 

  • Trouillas P. Immunology and immunotherapy of cerebral tumors. Current status. Rev Neurol (Paris) 1973;128:23–38.

    CAS  Google Scholar 

  • Tucker GC. Alpha v integrin inhibitors and cancer therapy. Curr Opin Investig Drugs 2003;4:723–731.

    Google Scholar 

  • Ueki K, Ono Y, Henson JW, Efird JT, von Deimling A, Louis DN. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated. Cancer Res 1996;56:150–153.

    PubMed  CAS  Google Scholar 

  • Vinkemeier U. Getting the message across, STAT! Design principles of a molecular signaling circuit. J Cell Biol 2004;167:197–201.

    Article  PubMed  CAS  Google Scholar 

  • von Deimling A, Eibl R, Ohgaki H, et al. p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma. Cancer Res 1992; 52:2987–2990.

    Google Scholar 

  • von Hanwehr RI, Hofman FM, Taylor CR, Apuzzo ML. Mononuclear lymphoid populations infiltrating the microenvironment of primary CNS tumors. Characterization of cell subsets with monoclonal antibodies. J Neurosurg 1984;60:1138–1147.

    Article  Google Scholar 

  • Warburg O. On the origin of cancer cells. Science 1956;123:309–314.

    Article  PubMed  CAS  Google Scholar 

  • Wheeler CJ, Das A, Liu G, Yu J, Black K. Clinical responsiveness of glioblastoma multiforme to chemotherapy after vaccination. Clin Cancer Res 2004;10: 5316–5326.

    Article  PubMed  CAS  Google Scholar 

  • Wikstrand CJ, Bigner DD. Hyperimmunization of non-human primates with BCG-CW and cultured human glioma-derived cells. Production of reactive antisera and absence of EAE induction. J Neuroimmunol 1981;1:249–260.

    Article  PubMed  CAS  Google Scholar 

  • Wikstrand CJ, Fredman P, Svennerholm L, Humphrey PA, Bigner SH, Bigner DD. Monoclonal antibodies to malignant human gliomas. [Review] Mol Chem Neuropathol 1992;17:137–146.

    Article  PubMed  CAS  Google Scholar 

  • Yu J, Liu G, Ying H, Yong WH, Black KL, Wheeler CJ. Vaccination with tumor lysate-pulsed dendritic cells elicits antigen-specific, cytotoxic T-cells in patients with malignant glioma. Cancer Res 2004;64:4973–4979.

    Article  PubMed  CAS  Google Scholar 

  • Yu J, Wheeler C, Zeltzer P, et al. Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic cytotoxicity and intracranial T-cell infiltration. Cancer Res 2001;61:842–847.

    PubMed  CAS  Google Scholar 

  • Yung WK, Prados MD, Yaya-Tur R, et al. Multicenter phase II trial of temozolomide in patients with anaplastic astrocytoma or anaplastic oligoastrocytoma at first relapse. Temodal Brain Tumor Group [published erratum appears in J Clin Oncol 1999;17:3693], J Clin Oncol 1999;17:2762–2771.

    Google Scholar 

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Authors
  1. Charles A. Conrad MD
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  2. Amy B. Heimberger MD
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Editor information

Editors and Affiliations

  1. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 442, 77030-4009, Houston, TX, USA

    Franco DeMonte MD

  2. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 431, 77030-4009, Houston, TX, USA

    Mark R. Gilbert MD

  3. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 97, 77030-4009, Houston, TX, USA

    Anita Mahajan MD

  4. The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 442, 77030-4009, Houston, TX, USA

    Ian E. McCutcheon MD

  5. The University of Texas M. D. Anderson Cancer Center, 77030-4009, Houston, TX, USA

    Aman U. Buzdar MD

  6. The University of Texas M. D. Anderson Cancer Center, 77030-4009, Houston, TX, USA

    Ralph S. Freedman MD, PhD

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© 2007 Springer Science+Business Media, LLC

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Conrad, C.A., Heimberger, A.B. (2007). Innovative Treatment Strategies for High-Grade Gliomas. In: DeMonte, F., Gilbert, M.R., Mahajan, A., McCutcheon, I.E., Buzdar, A.U., Freedman, R.S. (eds) Tumors of the Brain and Spine. M. D. Anderson Cancer Care Series. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-29202-1_9

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  • DOI: https://doi.org/10.1007/978-0-387-29202-1_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-29201-4

  • Online ISBN: 978-0-387-29202-1

  • eBook Packages: MedicineMedicine (R0)

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