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Small GTP Binding Proteins and the Control of Phagocytic Uptake

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Book cover Molecular Mechanisms of Phagocytosis

Part of the book series: Medical Intelligence Unit ((MIUN))

Abstract

Phagocytosis is a conserved cellular process in Eukaryotes. A multi-step process, it involves the recognition of paniculate material, e.g., microbes and apoptotic cells, their F-actin-driven engulfment and the subsequent destruction of the phagocytized material in phagolysosomes. Distinct sets of small GTP-binding proteins (Rap1, Arf6, Rho and Rab proteins) control and coordinate the successive steps of the phagocytic process. Moreover, these proteins are often targeted by microbial virulence factors. This review summarizes and discusses the evidence implicating Ras, Rho, Arf and Rab-family GTPases in the signalling pathways driving particle recognition and uptake.

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  1. Department of Biological Sciences, Centre for Molecular Microbiology and Infection, Imperial College London, London, UK

    Agnès Wiedemann, Jenson Lim & Emmanuelle Caron

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  1. Agnès Wiedemann
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Wiedemann, A., Lim, J., Caron, E. (2005). Small GTP Binding Proteins and the Control of Phagocytic Uptake. In: Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-28669-3_6

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