Conclusion
Complement is a major opsonin in blood and in extracellular fluids that is a major mechanism for recognition and destruction of potential pathogen invaders. An important part of complement’s role in this process is the recognition by phagocytes of complement components, particularly C3, bound to the surfaces of these dangerous organisms. Of the C3 receptors on the phagocytes, the two in the integrin family appear extremely important. In particular, the exquisite sensitivity of these integrin complement receptors to cues from the environment of the phagocytic cells help increase the efficiency with which they internalized opsonized targets for destruction and help limit their function to sites of inflammatory perturbation of homeostasis. Much has been learned about the molecular mechanisms involved in regulation of integrin receptor function, but many important events in the signal transduction cascades that lead to increased affinity for ligand and increased integrin clustering required for ingestion remain to be elucidated.
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Brown, E. (2005). Complement Receptors, Adhesion, and Phagocytosis. In: Molecular Mechanisms of Phagocytosis. Medical Intelligence Unit. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-28669-3_4
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DOI: https://doi.org/10.1007/978-0-387-28669-3_4
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