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5 Fabrication Issues of Biomedical Micro Devices

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BioMEMS and Biomedical Nanotechnology

Abstract

Biomedical micro devices (BMMD) are microsystems, which can be used in surgery, biomedical diagnostics, and therapeutic management [28]. These devices allow precise surgical procedures with spatial control in the micrometer range. The minimal invasive approach enables faster recovery for patients through shorter access pathways and reduced operation trauma. BMMDs for biomedical diagnostics and therapeutic management utilizes microfluidic technology that allows faster screening of common diseases as well as painless and effective drug delivery. The successful development and introduction of these technologies in health care will have a great impact on the living quality of patients, and significantly lower the total cost of medical treatment.

Biomedical micro devices (BMMD) are microsystems, which can be used in surgery, biomedical diagnostics, and therapeutic management [28]. These devices allow precise surgical procedures with spatial control in the micrometer range. The minimal invasive approach enables faster recovery for patients through shorter access pathways and reduced operation trauma. BMMDs for biomedical diagnostics and therapeutic management utilizes microfluidic technology that allows faster screening of common diseases as well as painless and effective drug delivery. The successful development and introduction of these technologies in health care will have a great impact on the living quality of patients, and significantly lower the total cost of medical treatment.

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References

  1. H. Becker and GÄrtner. Electrophoresis, 21:12, 2000.

    Article  Google Scholar 

  2. D.J. Beebe, G.A. Mensing, and G.M. Walker. Annu. Rev. Biomed. Eng., 4:261, 2002.

    Article  Google Scholar 

  3. J. Black. Biological Performance of Materials. Marcel Dekker, New York, 1992.

    Google Scholar 

  4. A. Braithwaite and F.J. Smith. Chromatographic Methods. 5. ed., Blackie Academic&Professional, London, 1996.

    Google Scholar 

  5. M.G. Cowie. Polymers: Chemistry and Physics of Modern Materials. Intertext, Aylesbury, 1973.

    Google Scholar 

  6. C.S. Effenhauser, A. Manz, and H.M. Widmer. Anal. Chem., 65:2637, 1993.

    Article  Google Scholar 

  7. V. Ghica and W. Glashauser (Verfahren für die spannungsfreie Entwicklung von bestrahlten Polymethylmethacrylate-Schichten. German Patent, #3039110, 1982).

    Google Scholar 

  8. C. Gonzalez, S.D. Collins, R.L. Smith. Sens. Actu. B, 49:40, 1998.

    Article  Google Scholar 

  9. D.J. Harrison, A. Manz, Z.H. Fan, H. Lüdi, and H.M. Widmer. Anal. Chem., 64:1926, 1992.

    Article  Google Scholar 

  10. A.C. Henry, T.J. Tutt, M. Galloway, Y.Y. Davidson, C.S. McWhorter, S.A. Soper, and R.L. McCarley. Anal. Chem., 72:5331, 2000.

    Article  Google Scholar 

  11. T.A. Horbett. Protein Adsorption on Biomaterials: Iterfacial Phenomena and Applications. American Chemical Society, Washington D.C., 2002.

    Google Scholar 

  12. Q.A. Huang and N.K.S. Lee. J. Micromech. Microeng., 9:64, 1999.

    Article  Google Scholar 

  13. D. Hülsenberg. Microelectron. J., 28:419, 1997.

    Article  Google Scholar 

  14. S.C. Jacobson, L.B. Kountny, R. Hergenröder, A.W. Moore, and J.M. Ramsey. Anal. Chem., 66:3472, 1994.

    Article  Google Scholar 

  15. S.C. Jacobson, R. Hergenröder, L.B. Coutny, and J.M. Ramsey. Anal. Chem., 66:2369, 1994.

    Article  Google Scholar 

  16. B.H. Jo et al. J. Micromech. Microeng., 9:76, 2000.

    Google Scholar 

  17. H. Klank, J.P. Kutter, and O. Geschke. Lab on a Chip, 2:242, 2002.

    Article  Google Scholar 

  18. P. Krulevitch, W. Benett, J. Hamilton, M. Maghribi, and K. Rose. Biomed. Microdev., 4:301, 2002.

    Article  Google Scholar 

  19. C.H. Lin, G.B. Lee, Y.H. Lin, and G.L. Chang. J. Micromech. Microeng., 11:726, 2001.

    Article  Google Scholar 

  20. A.P. London. Development and Test of a Microfabricated Bipropellant Rocket Engine. Ph.D. Thesis, Massachusetts Institute of Technology, 2000.

    Google Scholar 

  21. H. Lorenz et al. J. Micromech. Microeng., 7:121, 1997.

    Article  Google Scholar 

  22. C. Luo, J. Garra, T. Schneider, R. White, J. Currie, and M. Paranjape. A New Method to Release SU-8 Structures Using Polystyrene for MEMS Applications. In Proceedings of the 16th European Conference on Solid-StateTranducers, 2002.

    Google Scholar 

  23. M.J. Madou. Fundamentals of Microfabrication: The Science of Miniaturization. (2. ed., CRC Press, Boca Raton, 2002.

    Google Scholar 

  24. J.C. McDonald, D.C. Duffy, J.R. Anderson, D.T. Chiu, H. Wu, O.J.A. Schueller, and G.M. Whitesides. Electrophoresis, 21:27, 2000.

    Article  Google Scholar 

  25. E. Meng, S.Wu, andY.-C. Tai. Micro Total Analysis System 2000. Kluwer Academic Publishers, Netherlands, 2000.

    Google Scholar 

  26. N.T. Nguyen and S.T. Wereley. Fundametals and Applications of Microfluidics. Artech House, Boston, 2002.

    Google Scholar 

  27. N.T. Nguyen, T.Q. Truong, K.K. Wong, S.S. Ho, L.N. Low. J. Micromech. Microeng., 14:69, 2003.

    Google Scholar 

  28. D.L. Polla, A.G. Erdman, W.P. Robbins, D.T. Markus, J. Diaz-Diaz., R. Rizq, Y. Nam, H.T. Brickner, A. Wang, and P. Krulevitch. Annu. Rev. Biomed. Eng., 2:551, 2000.

    Article  Google Scholar 

  29. R. Salim, H. Wurmus, A. Harnisch, and D. Hülsenberg. Microsys. Technol., 4:32, 1997.

    Article  Google Scholar 

  30. K. Seiler, D.J. Harrison, and A. Manz. Anal. Chem., 65:1481, 1993.

    Article  Google Scholar 

  31. S.A. Soper, S.M. Ford, S. Qi, R.L. McCarley, K. Kelley, and M.C. Murphy. Anal. Chem., 72:643A, 2000.

    Article  Google Scholar 

  32. G. Spierings. J. Mater. Sci., 28:6261, 1993.

    Article  Google Scholar 

  33. R. Srinivasan. Appl. Phys., 73:6, 1993.

    Google Scholar 

  34. L.F. Thompson, C.G. Willson, and M.J. Bowden. Introduction to Microlithography. Americal Chemical Society, Washington D.C., 1994.

    Google Scholar 

  35. T.Q. Truong and N.T. Nguyen. J. Micromech. Microeng., 14:632, 2004.

    Article  Google Scholar 

  36. W. Wijngarrt et al. The First Self-Priming and Bi-Directional Valve-Less Diffuser Micropump for Both Liquid and Gas. In Proceedings of MEMS’00 the 13th IEEE International Workshop on MEMS, 2000.

    Google Scholar 

  37. A.T. Wolly and R.A. Mathies. Anal. Chem., 67:3676, 1995.

    Article  Google Scholar 

  38. Y. Xia and G.M. Whitesides. Annu. Rev. Mater. Sci., 28:153, 1998.

    Article  Google Scholar 

  39. T.J. Yao et al. Micromachined Rubber O-Ring Micro-Fluidic Couplers. In Proceedings of MEMS’00 the 13th IEEE International Workshop on MEMS, 2000.

    Google Scholar 

  40. G. Voskericiana, M.S. Shivea, R.S. Shawgoc, H. von Recumd, J.M. Andersona, M.J. Cimac, and R. Langere. Biomaterials, 24:1959, 2003.

    Article  Google Scholar 

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Authors and Affiliations

  1. School of Mechanical and Production Engineering, Nanyang Technological University, 50. Nanyang Avenue, Singapore, 639798

    Nam -Trung Nguyen

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  1. Nam -Trung Nguyen
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  5. Texas Alliance for NanoHealth, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  6. Purdue University, West Lafayette, Indiana

    Rashid Bashir  & Steve Wereley  & 

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Nguyen, N.T. (2006). 5 Fabrication Issues of Biomedical Micro Devices. In: Ferrari, M., Bashir, R., Wereley, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25845-4_5

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  • DOI: https://doi.org/10.1007/978-0-387-25845-4_5

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25566-8

  • Online ISBN: 978-0-387-25845-4

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