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BioMEMS and Biomedical Nanotechnology pp 305–323Cite as

Supported Lipid Bilayers as Mimics for Cell Surfaces and as Tools in Biotechnology

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Abstract

The phospholipid bilayer is a universal molecular architecture that is shared by all cell membranes. The canonical vision of this material is a fluid mosaic [1] of proteins, lipids, and cholesterol that exhibits both a high degree of lateral fluidity and heterogeneity [2, 3]. There is widespread evidence for miscibility phase separation in membranes [4–6]. The membrane thus consists of a nanoemulsion of two-dimensional phase domains, often referred to as rafts, which are dynamic entities populated with distinctive and changing sets of proteins. The localization and cooperative arrangement of membrane components, especially in the 1–1000nmsize range, is broadly implicated in many facets of cell membrane function. There is tremendous interest, both from academy and industry, in membrane lateral structure and the way it regulates the activity of constituent membrane proteins.

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Authors and Affiliations

  1. Department of Chemistry, University of California Berkeley, Berkeley, CA, 94720

    JayT. Groves

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Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  2. University of Texas M.D. Anderson Cancer Center, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  5. Houston, TX

    Mauro Ferrari Ph.D. (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth) (Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President,the Texas Alliance for NanoHealth)

  6. Dept. of Bioengineering and Physiology, University of California, San Francisco, CA

    Tejal Desai

  7. Harvard—MIT Division of Health Sciences & Technology, Electrical Engineering & Computer Science, Massachusetts Institute of Technology, MA

    Sangeeta Bhatia

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Groves, J. (2006). Supported Lipid Bilayers as Mimics for Cell Surfaces and as Tools in Biotechnology. In: Ferrari, M., Desai, T., Bhatia, S. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25844-7_17

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