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Centrifuge Based Fluidic Platforms

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BioMEMS and Biomedical Nanotechnology

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Abstract

Once it became apparent that individual chemical or biological sensors used in complex samples would not attain the hoped for sensitivity or selectivity, wide commercial use became severely hampered and sensor arrays and sensor instrumentation were proposed instead. It was projected that by using orthogonal sensor array elements (e.g., in electronic noses and tongues) selectivity would be improved dramatically [1]. Instrumentation—it was envisioned—would reduce matrix complexities through filtration, separation, and concentration of the target compound, while, at the same time, ameliorating selectivity and sensitivity of the overall system by frequent recalibration and washing of the sensors. Through miniaturization of analytical equipment (using microfluidics), shortcomings associated with large and expensive instrumentation may potentially be overcome: reduction in reagent volumes, favorable scaling properties of several important instrument processes (basic theory of hydrodynamics and diffusion predicts faster heating and cooling and more efficient chromatographic and electrophoretic separations in miniaturized equipment) and batch-fabrication which may enable low cost, disposable instruments to be used once and then thrown away to prevent sample contamination [2]. Micromachining (MEMS) might also allow co-fabrication of many integrated functional instrument blocks. Tasks that are now performed in a series of conventional bench top instruments could then be combined into one unit, reducing labor and minimizing the risk of sample contamination.

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References

  1. E. Verpoorte, Manz, C.S. Effenhauser, N. Burggraf, D.E. Raymond, D.J. Harrison, and H.M. Widmer. Miniaturization of separation techniques using planar chip technology, HRC High Resol. Chromatogra., 16:433–36, 1993.

    Article  Google Scholar 

  2. Marc J. Madou. Fundamentals of Microfabrication, 2nd Ed., CRC Press, Boca Raton, London, New York, Washington D.C., 2002.

    Google Scholar 

  3. S. Miyazaki, T. Kawai, and M. Araragi. A Piezo-Electric Pump Driven by a Flexural Progressive Wave. In Proceedings: IEEE Micro Electro Mechanical Systems (MEMS’ 91), Nara, Japan, pp. 283–88, 1991.

    Google Scholar 

  4. J.W. Jorgenson and E.J. Guthrie. Liquid chromatography in open-tubular columns, J. Chromatogr., 255:335–48, 1983.

    Article  Google Scholar 

  5. D.J. Harrison, Z. Fan, K. Fluri, and K. Seiler. Integrated Electrophoresis Systems for Biochemical Analyses. In Technical Digest: 1994 Solid State Sensor and Actuator Workshop, Hilton Head Island, S.C., pp. 21–24, 1994.

    Google Scholar 

  6. D.C. Duffy, H.L. Gills, J. Lin, N.F. Sheppard, and G.J. Kellogg. Microfabicated centrifugal microfluidic systems: characterization and multiple enzymatic assays, Anal. Chemi., 71(20):4669–4678, 1999.

    Article  Google Scholar 

  7. M.J. Madou and G.J. Kellogg. The LabCDTM: a centrifuge-based microfluidic platform for diagnostics. In G.E. Cohn and A. Katzir (eds.), Systems and Technologies for Clinical Diagnostics and Drug Discovery, Vol. 3259, San Jose, Calif.: SPIE, pp. 80–93, 1998.

    Google Scholar 

  8. G.T.A. Kovacs. Micromachined Transducers Sourcebook, WCB/McGraw-Hill, Boston, chapter 9, pp. 787–793, 1998.

    Google Scholar 

  9. Gunnar Ekstrand, Claes Holmquist, Anna Edman örlefors, Bo Hellman, Anders Larsson, and Per Anderson, Microfluidics in a rotating CD. In A. van den Berg,W. Olthuis, and P. Bergveld (eds.), Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 311–314, 2000.

    Google Scholar 

  10. Anna-Lisa Tiensuu, Ove öhman, Lars Lundbladh, and Olle Larsson, Hydrophobic valves by ink-jet printing on plastic CDs with integrated microfluidics, In A. van den Berg, W. Olthuis, P. Bergveld (eds.), Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 575–578, 2000.

    Google Scholar 

  11. Marc J. Madou, Yumin Lu, Siyi Lai, Jim Lee, and Sylvia Daunert. A centrifugal microfluidic platform—a comparison, In A. van den Berg, W. Olthuis, and P. Bergveld. Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 565–570, 2000.

    Google Scholar 

  12. Jun Zeng, Deb Banerjee, Manish Deshpande, John R. Gilbert, David C. Duffy, and Gregory J. Kellogg. Design analysis of capillary burst valves in centrifugal microfluidics. In A. van den Berg, W. Olthuis, P. Bergveld (eds.), Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 579–582, 2000.

    Google Scholar 

  13. I.H.A. Badr, R.D. Johnson, M.J. Madou, and L.G. Bachas. Fluorescent ion-selective optode membranes incorporated onto a centrifugal microfluidics platform, Analytical Chemistry, 74(21):5569–5575, Nov 2002.

    Article  Google Scholar 

  14. R.D. Johnson, I.H.A. Badr, Gary Barrett, Siyi Lai, Yumin Lu, Marc J. Madou, and Leonidas G. Bachas. Development of a fully integrated analysis system for ions based on ion-selective optodes and centrifugal microfluidics. Anal. Chem., 73(16):3940–3946, Aug 2001.

    Article  Google Scholar 

  15. M. McNeely, M. Spute, N. Tusneem, and A. Oliphant. Hydrophobic microfluidics. Proceedings Microfluidic Devices and Systems, SPIE, Vol. 3877, pp. 210–220, 1999.

    Google Scholar 

  16. Application Report 101, Gyrolab MALDI SP1, Gyros AB, Uppsala, Sweden.

    Google Scholar 

  17. S. Lai, S. Wang, J. Luo, J. Lee, S. Yang, and M.J. Madou. Compact Disc (CD) Platform for Enzyme-Linked Immunosorbant Assays Manuscript submitted to Analytical Chemistry.

    Google Scholar 

  18. Gregory J.Kellogg,T odd E. Arnold, Bruce L. Carvalho, David C. Duffy, and Norman F. Sheppard, Centrifugal microfluidics: applications. In A. van den Berg, W. Olthuis, and P. Bergveld (eds.), Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 239–242, 2000.

    Google Scholar 

  19. Nick Thomas, Anette Ocklind, Ingrid Blikstad, Suzanne Griffiths, Michael Kenrick, Helene Derand, Gunnar Ekstrand, Christel Ellström, Anders Larsson, and Per Anderson Integrated cell based assays in microfabricated disposable CD devices. In A. van den Berg, W. Olthuis, and P. Bergveld (eds.), Micro Total Analysis Systems 2000, Kluwer Academic Publishers, pp. 249–252, 2000.

    Google Scholar 

  20. A.W. Anderson. Physical Chemistry of Surfaces, JohnWiley & Sons, New York, London, Sidney, Chapter1, pp. 5–6, 1960.

    Google Scholar 

  21. D.C. Duffy, J.C. McDonald, O.J.A. Schueller, and G.M. Whitesides. Rapid prototyping of microfluidic systems in Poly(dimethylsiloxane), Anal. Chem., 70:4974–4984, 1998.

    Article  Google Scholar 

  22. J. Burbaum, Minitaturization technologies in HTS: how fast, how small, how soon?, Drug Discov Today, 3(7):313–312, 1998.

    Article  Google Scholar 

  23. Jim V. Zoval, Richard Boulanger, Charles Blackwell, Bruce Borchers, Michael Flynn, David Smernoff, Ragnhild Landheim, Rocco Mancinelli Marc J. Madou. Cell Viability Assay on a Rotating Disc Analytical System, Manuscript of paper in preparation.

    Google Scholar 

  24. M.G. Pollack, A.D. Shenderov, and R.B. Fair, Electrowetting-based actuation of droplets for integrated microfluidics, Lab on a chip, 2:96–101, 2002.

    Article  Google Scholar 

  25. M.J. Madou, L. James Lee, S. Daunert, S. Lai, and C.-H. Shih. Design and fabrication of CD-like microfluidic platforms for diagnostics: microfluidic functions. Biomed. Microdevi., 3(3):245–254, 2001.

    Article  Google Scholar 

  26. T. Brenner, T. Glatzel, R. Zengerle, and J. Ducree, A Flow Switch Based on Coriolis Force, 7th International Conference on Miniaturized Chemical Biochemical Analysis Systems.

    Google Scholar 

  27. D.D. Carlo, K-H Jeong, and L. P. Lee, Reagentless mechanical cell lysis by nanoscale barbs in microchannels for sample preparation, Lab on a Chip, 3:287–291, 2003.

    Article  Google Scholar 

  28. S.W. Lee, H. Yowanto, and Y.C. Tai. Micro Cell Lysis Device, The 11th Annual International Workshop on Micro Electro Mechanical Systems, MEMS’ 98.

    Google Scholar 

  29. J. Sambrook and D. W. Russell.Molecular Cloning, Cold Spring Harbor Laboratory press, Cold spring harbor, New York, 2001.

    Google Scholar 

  30. Amy Q. Shen, Granular fingering patterns in horizontal rotating cylinders. Physics of Fluids, 14(2)462–470, 2002.

    Article  Google Scholar 

  31. L. Bocquet,W. Losert, D, Schalk, T.C. Lubensky, and J.P. Gollub. Granular shear flow dynamics and forces: experiment and continuum theory, Physical Review E (65), 011307–1.

    Google Scholar 

  32. K.J. Ruschak and L.E. Scriven, Rimming flow of liquid in a rotating horizontal cylinder, Fluid Mech. 76:113–127, 1976.

    Article  MATH  Google Scholar 

  33. S.T. Thoroddsen and L. Mahadevan. Experimental Study of coating flows in a partially-filled horizontally rotating cylinder, Exper. Fluids, 23:1–13, 1997.

    Article  Google Scholar 

  34. R.A. Bagnold. Experiments on a gravity-free dispersion of large solid spheres in a Newtonian fluid under shear,” Proceedings of the Royal Society of London. Series A, Mathematical and Physical Sciences, “ 225(1160):49–63, 1954.

    Google Scholar 

  35. Cliff K.K. Lun, Granular dynamics of inelastic spheres in Couette flow, Phys. Fluids, 8(11), 1996.

    Google Scholar 

  36. S.F. Foerster, M.Y. Louge, H. Chang, and K. Allia. Measurements of the collision properties of small spheres, Phy. Fluids 6(3), 1994.

    Google Scholar 

  37. G.K. Batchelor. A new theory of the instability of a uniform fluidized bed, J. Fluid Mech., 193:75–110, 1988.

    Article  MATH  MathSciNet  Google Scholar 

  38. R. Zenit, M.L. Hunt, and C.E. Brennen. “Collisional particle pressure measurements in solid-liquid flows, Fluid Mech. 353:261–283, 1997.

    Article  Google Scholar 

  39. S.A. Morsi and A.J. Alexander. An investigation of particle trajectories in two-phase flow systems, Fluid Mech., 55(2):193–208, 1972.

    Article  MATH  Google Scholar 

  40. J. Kirchner J, S.B. Sandmeyer, and D.B. Forrest. Transposition of a Ty3GAG3-POL3 fusion mutant is limited by availability of capsid protein, Virol., 66(10):6081–92, 1992.

    Google Scholar 

  41. R. Barathur, J. Bookout, S. Sreevatsan, J. Gordon, M. Werner, G. Thor, and M. Worthington. New disc-based technologies for diagnostic and research applications, Psychiat. Geneti., (12)4:193–206, 2002.

    Google Scholar 

  42. I. Alexandre, Y.Houbion, J. Collet, S. Hamels, J. Demarteau, J.-L. Gala, and J. Remacle. Compact disc with both numeric and genomic information as DNA microarray platform, BioTechniques, (33)2:435, 2002.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Irvine Department of Mechanical and Aerospace Engineering, University of California, USA

    Jim V. Zoval

  2. Irvine Department of Mechanical and Aerospace Engineering and Department of Biomedical Engineering, University of California, USA

    M. J. Madou

Authors
  1. Jim V. Zoval
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  2. M. J. Madou
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Editor information

Editors and Affiliations

  1. Department of Biomedical Engineering, University of Texas Health Science Center, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  2. Anderson Cancer Center, University of Texas M.D., Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  3. Rice University, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  4. University of Texas Medical Branch, Galveston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  5. Texas Alliance for NanoHealth, Houston, TX

    Mauro Ferrari Ph.D. (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President) (Editor-in-Chief, Professor, Brown Institute of Molecular Medicine Chairman, Professor of Experimental Therapeutics, Professor of Bioengineering, Professor of Biochemistry and Molecular Biology, President)

  6. Dept. of Electrical Engineering, University of California Riverside, Riverside, California, USA

    Mihrimah Ozkan

  7. Dept. of Bioengineering, University of California, San Diego La Jolla, California, USA

    Michael J. Heller

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Zoval, J.V., Madou, M.J. (2006). Centrifuge Based Fluidic Platforms. In: Ferrari, M., Ozkan, M., Heller, M.J. (eds) BioMEMS and Biomedical Nanotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25843-0_10

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  • DOI: https://doi.org/10.1007/978-0-387-25843-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-25564-4

  • Online ISBN: 978-0-387-25843-0

  • eBook Packages: EngineeringEngineering (R0)

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