Abstract
At first glance, the study of fetal development may seem tangential in a book about the nursery rearing of infant monkeys. The nursery environment is essential, however, to a discipline that seeks to understand the complex mechanisms of prenatal development. As in studies of postnatal development, the subjects of prenatal research need an environment in which they can thrive and in which they can be accessed at specific time points so that their development can be studied and manipulated systematically. Such studies are necessary if we are to understand the genetic and environmental influences underlying normal and abnormal development of the human fetus. Whereas ethical and practical limitations preclude the use of humans in these studies, nonhuman primates offer an excellent opportunity to model many human developmental processes (Newell-Morris and Fahrenbruch, 1985). And, these nonhuman primates frequently need nursery care, especially if the effect of prenatal manipulations are unknown, putting them at risk for poor postnatal development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Alexander, N.J. (1972). Prenatal development of the ductus epididymidis in the rhesus monkey: The effects of fetal castration. Am. J. Anat. 135:119–134.
Archer, J., and Blackman, D. (1971). Prenatal psychological stress and offspring behavior in rats and mice. Dev. Psychobiol. 4:193–248.
Astley, C.A., Hohimer, A.R., Stephenson, R.B., Smith, O.A., and Spelman, F.A. (1979). Effect of implant duration on in vivo sensitivity of electromagnetic flow transducers. Am. J. Physiol. 236:H508–H512.
Bennett, M., Galan, H., Owens, G., Dewey, R., Banks, R., Hobbins, J., Accurso, F., and Schaack, J. (2001). In utero gene delivery by intraamniotic injection of a retroviral vector producer cell line in a nonhuman primate model. Hum. Gene Ther. 12:1857–1865.
Blum, T., Saling, E., and Bauer, R. (1985). First magnetoencephalography recordings of the brain activity of a human fetus. Br. J. Obstet. Gynaccol. 92:1224–1229.
Bowden, D.M., Weathersbee, P.S., Clarren, S.K., Fahrenbruch, C.E., Goodlin, B.L., and Caffery, S.A. (1983). A periodic dosing model of fetal alcohol syndrome in the pig-tailed macaque (Macaca nemestrina). Am. J. Primatol. 4:143–157.
Burbacher, T.M., and Grant, K.S. (2000). Methods for studying nonhuman primates in neurobehavioral toxicology and teratology. Neurotoxicol. Teratol. 22:475–486.
Burbacher, T.M., Grant, K.S., and Mottet, N.K. (1990a). Retarded object permanence development in methylmercury exposed Macaca fascicularis infants. Dev. Psychol. 22:771–776.
Burbacher, T.M., Sackett, G.P., and Mottet, N.K. (1990b). Methylmercury effects on the social behavior of Macaca fascicularis infants. Neurotoxicol. Teratol. 12:65–71.
Butler, H. (1983). The Embryology of the Lesser Galago (Galago senegalensis). Karger, Basel.
Canfield, D., Brignolo, L., Peterson, P.E., and Hendrickx, A.G. (2000). Conjoined twins in a rhesus monkey. J. Med. Primatol. 29:427–430.
Chan, A.W.S., Luetjens, C.M., Dominko, T., Ramalho-Santos, J., Simerly, C.R., Hewitson, L., and Schatten, G. (2000). Foreign DNA transmission by ICSI: Injection of spermatozoa bound with exogenous DNA results in embryonic GFP expression and live rhesus monkey births. Mol. Hum. Reprod. 6:26–33.
Chan, A.W.S., Chong, K.Y., Martinovich, C., Simerly, C., and Schatten, G. (2001). Transgenic monkeys produced by retroviral gene transfer in mature oocytes. Science 290:309–311.
Clarke, A.S., and Schneider, M.L. (1993). Prenatal stress has long term effects on behavioral responses to stress in juvenile rhesus monkeys. Dev. Psychobiol. 26:293–304.
Clarren, S.K., and Bowden, D.B. (1984). Measures of alcohol damage in utero in the pigtailed macaque (Macaca nemestrina). Ciba Found. Symp. 105:157–172.
Coe, C.L., and Crispen, H.R. (2000). Social stress in pregnant squirrel monkeys (Saimiri boliviensis peruviensis) differentially affects placental transfer of maternal antibody to male and female infants. Health Psychol. 19:554–559.
Conrad, S., Ha, J., Lohr, C., and Sackett, G. (1995). Ultrasound measurement of fetal growth in Macaca nemestrina. Am. J. Primatol. 36:15–35.
Diczfalusy, E. (1974). Endocrine function of the human fetus. Am. J. Obstet. Gynecol. 119:419–433.
Eaton, G.G., Worlein, J.M., and Glick, B.B. (1990). Sex differences in Japanese macaques (Macaca fuscata): Effects of prenatal testosterone on juvenile social behavior. Horm. Behav. 24:270–283.
Engle, M.J., Kemnitz, J.W., Rao, T.J., Perelman, R.H., and Farrel, P.M. (1996). Effects of maternal dexamethasone therapy on fetal lung development in the rhesus macaque. Am. J. Perinatol. 13:399–407.
Eswaran, H., Lowery, C.L., Robinson, S.E., Wilson, J.D., Cheyne, D., and McKenzie, D. (2000). Challenges of recording human fetal auditory-evoked response using magnetoencephalography. J. Matern. Fetal Med. 9:303–307.
Fahrenbruch, C.E., Burbacher, T.M., and Sackett, G.P. (1979). Gross morphology and pregnancy outcome in Macaca nemestrina. In: Ruppenthal, G.C., and Reese, D.J. (eds.), Nursery Care of Nonhuman Primates. Plenum Press, New York, pp. 27–34.
Farine, D., MacCarter, G.D., Timor-Tritch, I.E., Yeh, M.N., and Stark, R.I. (1988). Real-time ultrasonic evaluation of the baboon pregnancy: Biometric measurements. J. Med. Primatol. 17:215–221.
Feitz, W.F., Steegers, E.A., Aarnink, R.G., Arts, T., De Vries, J.D., and Van der Wildt, B. (1996). Endoscopic intrauterine fetal therapy: A monkey model. Urology 47:118–119.
Gelowitz, D.L., Rakic, P., Goldman-Rakic, P.S., and Selemon, L.D. (2002). Craniofacial dysmorphogenesis in fetally irradiated nonhuman primates: Implications for the neurodevelopmental hypothesis of schizophrenia. Biol. Psychiatry 52:716–720.
Gerschenson, M., and Poirier, M.C. (2000). Fetal patas monkeys sustain mitochondrial toxicity as a result of in utero zidovudine exposure. Ann. N. Y. Acad. Sci. 918:269–281.
Golub, M.S., Sassenrath, E.N., and Chapman, L.F. (1981). Mother-infant interaction in rhesus monkeys treated chronically with delta-9-tetrahydrocannabinol. Child Dev. 52:389–392.
Golub, M.S., Sassenrath, E.N., and Chapman, L.F. (1982). An analysis of altered attention in monkeys exposed to delta-9-tetrahydrocannabinol during development. Neurobehav. Toxicol. Teratol. 4:469–472.
Goy, R.W., and Deputte, B.L. (1996). The effects of diethylstilbesterol (DES) before birth on the development of masculine behavior in juvenile rhesus monkeys. Horm. Behav. 30:379–386.
Goy, R. W., Bercovitch, F.B., and McBrair, M.C. (1988). Behavioral masculinization is independent of genital masculinization in prenatally androgenized female rhesus macaques. Horm. Behav. 22:552–571.
Gunderson, V.M., Grant, K.S., Burbacher, T.M., Fagan, J.F., 3rd., and Motter, N.K. (1986). The effect of low-level prenatal methylmercury exposure on visual recognition memory in infant crab-eating macaques. Child Dev. 57:1076–1083.
Gunderson, V.M., Grant-Webster, K.S., Burbacher, T.M., and Mottet, N.K. (1988). Visual recognition memory deficits in methylmercury-exposed Macaca fascicularis infants. Neurotoxicol. Teratol. 10:373–379.
He, N., Song, Z.M., and Lidow, M.S. (1999). Cocaine induces cell death within the primate fetal cerebral wall. Neuropathol. Appl. Neurobiol. 25:504–512.
Hendrickx, A.G. (1973). The sensitive period and malformation syndrome produced by thalidomide in crab-eating monkey (Macaca fascicularis). J. Med. Primatol. 2:267–276.
Hendrickx, A.G., and Helm, F.C. (1980). Nonteratogenicity of a structural analog of thalidomide in pregnant baboons (Papio cynocephalus). Teratology 22:179–182.
Hendrickx, A.G., and Newman, L. (1973). Appendicular skeletal and visceral malformations induced by thalidomide in bonnet monkeys. Teratology 7:151–159.
Hendrickx, A.G., and Sawyer, R.H. (1978). Developmental staging and thalidomide teratogenicity in the green monkey (Cercopithecus aethiops). Teratology 18:393–404.
Herman, R.A., Jones, B., Mann, D.R., and Wallen, K. (2000). Timing of prenatal androgen exposure: Anatomical and endocrine effects on juvenile male and female rhesus monkeys. Horm. Behav. 38:52–66.
Holm, R.A. (1979). Effects of parental risk and prenatal stress on pregnancy outcome. In: Ruppenthal, G.C., and Reese, D.J. (eds.), Nursery Care of Nonhuman Primates. Plenum Press, New York, pp. 21–26.
Howell, L.L., Schama, K.F., Ellis, J.E., Grimley, P.J., Kitchens, A.J., and Byrd, L.D. (2001). Fetal development in rhesus monkeys exposed prenatally to cocaine. Neurotoxicol. Teratol. 23:133–140.
Jaffe, R.B., Spencer, S.J., and Rabinovici, J. (1993). Activins and inhibins: Gonadal peptides during prenatal development and adult life. Ann. N.Y. Acad. Sci. 687:1–9.
Kaplan, J.N., Henessey, M.B., and Howd, R.A. (1982). Oral ethanol intake and levels of blood alcohol intake in the squirrel monkey. Pharmacol. Biochem. Behav. 17:111–117.
Kittinger, G.W. (1977). Endocrine regulation of fetal development and its relation to parturition in the rhesus monkey. Ciba Found. Symp. 47:235–257.
Klein, N.W., Plenefisch, J.D., Carey, S.W., Fredrickson, W.T., Sackett, G.P., Burbacher, T.M., and Parker, R.M. (1982). Serum from monkeys with histories of fetal wastage causes abnormalities in cultured rat embryos. Science 215(4528):66–69.
Lorson, J.E., Morrow, S.L., Delcarpio, J.B., Bohm, R.P., Ratterree, M.S., Blanchard, J.L., and Cohen, J.C. (2000). Gene transfer into the fetal primate: Evidence for the secretion of transgene product. Mol. Ther. 2:631–639.
Lecanuet, J.P., Fifer, W.P., Krasnegor, N.A., and Smotherman, W.P. (eds.). (1995). Fetal Development: A Psychobiological Perspective. Lawrence Erlbaum Associates, Hillsdale, NJ.
Lengle, J.M., Chen, M., and Wakai, R.T. (2001). Improved neuromagnetic detection of fetal and neonatal auditory evoked responses. Clin. Neurophysiol. 112:785–792.
Levitt, P., and Rakic, P. (1982). The time of genesis, embryonic origin and differentiation of the brain stem monoamine neurons in the rhesus monkey. Dev. Brain Res. 4:35–57.
Lidow, M.S., and Song, Z.M. (2001). Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons. J. Comp. Neurol. 435:259–262.
Mahoney, C.J., Eisele, S., and Capriolo, M. (1977). Clinical indications for caesarian section in the rhesus monkey. In: Ruppenthal, G.C., and Reese, D.J. (eds.), Nursery Care of Nonhuman Primates. Plenum Press, New York, pp. 3–20.
Meng, L., Ely, J.J., Stoufer, R.L., and Wolf, D.P. (1997). Rhesus monkeys produced by nuclear transfer. Biol. Reprod. 57:454–459.
Menzie, A.J. (2002). “Star Trek” sensors monitor health. Associated Press [on-line]. August 23, 2002, http://www.msnbc.com/news/796105.asp.
Michael, R.P., and Zumpe, D. (1998). Developmental changes in behavior and in steroid uptake by the male and female macaque brain. Dev. Neuropsychol. 14:233–260.
Michael, R.P., Zumpe D., and Bonsall, R.W. (1992). The interaction of testosterone with the brain of the orchidectomized primate fetus. Brain Res. 570:68–74.
Mintz, G.S., Weissman, M.D., and Fitzgerald, P.J. (2001). Intravascular ultrasound assessment of the mechanisms and results of brachytherapy. Circulation 104:1320–1325.
Morris, P., Binienda, Z., Gillam, M.P., Harkey, M.R., Zhou, C., Henderson, G.L., and Paule, M.G. (1996). The effect of chronic cocaine exposure during pregnancy on maternal and infant outcomes in the rhesus monkey. Neurotoxicol. Teratol. 18:147–154.
Morris, P., Binienda, Z., Gillam, M.P., Klein, J., McMartin, K., Koren, G., Duhart, H.M., Slikker, W., and Paule, M.G. (1997). The effect of chronic cocaine exposure throughout pregnancy on maternal and infant outcomes in the rhesus monkey. Neurotoxicol. Teratol. 19:47–57.
Nathanielsz, P.W., Frank, D., Gleed, R., Dillingham, L., Figueroa, J.P., and Poore, E.R. (1984). Methods for investigation of the chronically instrumented pregnant rhesus monkey preparation maintained on a tether and swivel system. In: Nathanielsz, P.W. (ed.), Animal Models in Fetal Medicine. Perinatology Press, New York, pp. 109–159.
Newell-Morris, L., and Fahrenbruch, C. (1985). Practical and evolutionary considerations for use of the nonhuman primate model in prenatal research. In: Watts, E.S., (ed.), Nonhuman Primate Models for Growth and Development. Liss, New York, pp. 9–40.
Nimrod, C., Simpson, N., Hafner, T., de Vermette, R., Fournier, J., Coady, L., and Baccanale, C. (1996). Assessment of early placental development in the cynomolgus monkey (Macaca fascicularis) using colour and pulsed wave Doppler sonography. J. Med. Primatol. 25:106–111.
Novak, M.S. (2002). A model experimental system for studying prenatal stress in pigtailed macaque monkeys. Doctoral Dissertation. University of Washington, Seattle, WA.
Novak, M.F.S.X., and Sackett, G.P. (1996). Reflexive and early neonatal development in offspring of pigtailed macaques exposed to prenatal psychosocial stress. Dev. Psychobiol. 29:294.
Novy, M.J., and Walsh, S.W. (1981). Regulation of fetoplacental steroidogenesis in rhesus macaques. In: Novy, M.J., and Resko, J.A. (eds.), Fetal Endocrinology. Academic Press, New York, pp. 65–94.
Nubbemeyer, R., Heistermann, M., Oerke, A-K., and Hodges, J.K. (1997). Reproductive efficiency in the common marmoset (Callithrix jacchus): A longitudinal study from ovulation to birth monitored by ultrsonography. J. Med. Primatol. 26: 139–146.
Olivero, O.A., Fernandez, J.J., Antiochos, B.B., Wagner, J.L., St. Claire, M.E., and Poirier, M.C. (2002). Transplacental genotoxicity of combined antiretroviral nucleoside analogue therapy in Erythrocebus patas monkeys. J. Acquir. Immune Defic. Syndr. 29:323–329.
Parker, A. (2000). Imaging catheter gives surgeons the inside picture. Science and Technology Review. [On-line]. Lawrence Livermore National Laboratories. www.llnl.gov/str/daSilva.html.
Prahalada, S., Carroad, E., Cukierski, M., and Hendrickx, A.G. (1985). Embryotoxicity of a single dose of medroxyprogesterone acetate (MPA) and maternal serum MPA concentrations in cynomolgus monkey (Macaca fascicularis). Teratology 32:421–432.
Rakic, P. (1982). Early developmental events: Cell lineages, acquisition of neuronal positions, and aerial and laminar development. Neurosci. Res. Prog. Bull. 20:439–451.
Rakic, P. (1994). Corticogenesis in human and non-human primates. In: Gazzaniga, M.S. (ed.), Cognitive Neuroscience: A Handbook for the Field. MIT Press, Boston, pp. 127–145.
Robinson, S.R., and Smotherman, W.P. (1995). Habituation and classical conditioning in the rat fetus: Opioid involvements. In: Lecanuet, J.P., Fifer, W.P., Krasnegor, N.A., and Smotherman, W.P. (eds.), Fetal Development: A Psychobiological Perspective. Lawrence Erlbaum Associates, Hillsdale, NJ, pp. 295–314.
Ruppenthal, G.C., Moore, C.M., Best, R.G., Walker-Gelatt, C.G., Delio, P.J., and Sackett, G.P. (2004). Trisomy 16 in a pigtailed macaque (M. nemestrina) with multiple anomalies. Am. J. Ment. Retard. 109:9–20.
Sackett, G.P. (1980). A nonhuman primate model for studying the causes and effects of poor pregnancy outcome. In: Friedman, S., and Sigman, M. (eds.), Pre-term and Post-term Birth: Relevance to Optimal Psychological Development. Academic Press, San Diego, pp. 41–63.
Sackett, G.P. (1984). A nonhuman primate model of risk for deviant development. Am. J. Ment. Defic. 88:469–476.
Sackett, G.P. (1991). Toward a more temporal view of organism-environment interaction. In: Wachs, T.D., and Plomin, R. (eds.), Conceptualization and Measurement of Organism Environment Interaction. American Psychological Association, Washington D.C., pp. 11–28.
Sackett, G.P., Sameroff, A.J., Cairns, R.B., and Suomi, S.J. (1992). Continuity in behavioral development: Theoretical and empirical issues. In: Immelmann, K., Barlow, G., Petrinovich, L., and Main, M. (eds.), Behavioral Development: The Bielefeld Interdisciplinary Project. Cambridge University Press, London, pp. 23–57.
Sankai, T. (2000). Embryo production and embryo transfer. Exp. Anim. 49:69–81.
Schaie, K.W. (1965). A general model for the study of developmental problems. Psychol. Bull. 64(2):92–107.
Schindler, M.K., Wang, L., Selemon, L.D., Goldman-Rakic, P.S., Rakic, P., and Csernansky, J.G. (2002). Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mapping. Biol. Psychiatry 51: 827–837.
Schneider, M.L. (1992a). The effect of mild stress during pregnancy on birth-weight and neuromotor maturation in rhesus monkey infants (Macaca mulatta). Infant Behav. Dev. 15:389–403.
Schneider, M.L. (1992b). Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants. Dev. Psychobiol. 25:529–540.
Schneider, M.L. (1992c). Delayed object permanence development in prenatally stressed rhesus monkey infants (Macaca mulatta). Occup. Ther. J. Res. 12(2): 96–112.
Schneider, M.L., and Coe, C.L. (1993). Repeated social stress during pregnancy impairs neuromotor development of the primate infant. J. Dev. Behav. Pediatr. 14(2):81–87.
Schneider, M.L., Moore, C.F., and Becker, E.F. (2001a). Timing of moderate alcohol exposure during pregnancy and neonatal outcome in rhesus monkeys (Macaca mulatta). Alcoholism Clin. Exp. Res. 25:1238–1245.
Schneider, U., Schleussner, E., Haueisen, J., Nowak, H., and Seewald, H. (2001b). Signal analysis of auditory evoked cortical fields in fetal magnetoen-cephalography. Brain Topogr. 14:69–80.
Seier, J.V., van der Horst, G., de Kock, M., and Chwalisz, K. (2000). The detection and monitoring of early pregnancy in the vervet monkey (Cercopithecus aethiops) with the use of ultrasound and correlation with reproductive steroid hormones. J. Med. Primatol. 29:70–75.
Sekhon, H.S., Keller, J.A., Proskocil, B.J., Martin, E.L., and Spindel, E.R. (2002). Maternal nicotine exposure upregulates collagen gene expression in fetal monkey lung. Am. J. Respir. Cell. Mol. Biol. 26:31–41.
Selye, H. (ed.). (1980). Selye’s Guide to Stress Research. Van Nostrand Reinhold, San Francisco.
Sheifer, S.E., Canos, M.R., Weinfurt, K.P., Arora, U.K., Mendelsohn, F.O., Gersh, B.J., and Weissman, N.J. (2000). Sex differences in coronary artery size assessed by intravascular ultrasound. Am. Heart J. 139:649–653.
Shimizu, K. (1988). Ultrasonic assessment of pregnancy and fetal development in three species of macaque monkeys. J. Med. Primatol. 17:247–256.
Simpson, N.A.B., Nimrod, C., De Vermette, R., Leblanc, C., and Fournier, J. (1998). Sonographic evaluation of intervillous flow in early pregnancy: Use of echo-enhancement agents. Ultrasound Obstet. Gynecol. 11:204–208.
Smotherman, W.P. (2002). Classical conditioning in the rat fetus: Involvement of mu and kappa opioid systems in the conditioned response. Dev. Psychobiol. 40:104–115.
Smotherman, W.P., and Robinson, S.R. (1986). A method for endoscopic visualization of rat fetuses in situ. Physiol. Behav. 37:663–665.
Smotherman, W.P., and Robinson, S.R. (1988). Behavior of the rat fetus following chemical and tactile stimulation. Behav. Neurosci. 102:24–34.
Smotherman, W.P., Robinson, S.R., and Miller, B.J. (1986). A reversible preparation for observing the behavior of fetal rats in utero: Spinal anesthesia with lidocaine. Physiol. Behav. 37:57–60.
Tarantal, A.F., and Hendrickx, A.G. (1988). The use of ultrasonography for evaluating pregnancy in macaques. In: Neubert, D., Merker, H., and Hendrickx, A.G. (eds.), Non-Human Primates—Developmental Biology and Toxicology. Ueberreuter Wissenschaft, Berlin, pp. 91–111.
Tarantal, A.F., Gargosky, S.E., Ellis, D.S., O’Brien, W.D., Jr., and Hendrickx, A.G. (1995). Hematologic and growth-related effects of frequent prenatal ultrasound exposure in the long-tailed macaque (Macaca fascicularis). Ultrasound Med. Biol. 21(8):1073–1081.
Tarantal, A.F., O’Rourke, J.P., Case, S.S., Newbound, G.C., Li, J., Lee, C.I., Baskin, C.R., Kohn, D.B., and Bunnell, B.A. (2001). Rhesus monkey model for fetal gene transfer: Studies with retroviral-based vector systems. Mol. Ther. 3:128–138.
Tarantal, A.F., Castillo, A., Ekert, J.E., Bischofberger, N., and Martin, R.B. (2002). Fetal and maternal outcome after administration of tenofovir to gravid rhesus monkeys (Macaca mulatta). J. Acquir. Immune Defic. Syndr. 29:207–220.
Tarara, R. (1984). The effect of medroxyprogesterone acetate (Depo-Provera) on prenatal development in the baboon (Papio anubis): A preliminary study. Teratology 30:181–185.
Tomaszycki, M.L., Davis, J.E., Gouzoules, H., and Wallen, K. (2001). Sex differences in infant rhesus macaque separation-rejection vocalizations and effects of prenatal androgens. Horm. Behav. 39:267–276.
Uno, H., Lohmiller, L., Thieme, C., Kemnitz, J.W., Engle, M.J., Roecker, E.B., and Farrell, P.M. (1990). Brain damage induced by prenatal exposure to dexamethasone in fetal rhesus macaques, I: Hippocampus. Dev. Brain Res. 53:157–167.
Wahter, M., Motter, N.K., Friberg, L., Lind, B., Shen, D.D., and Burbacher, T. (1994). Speciation of mercury in the primate blood and brain following longterm exposure to methyl mercury. Toxicol. Appl. Pharmacol. 124:221–229.
Wakai, R.T., Leuthold, A.C., and Martin, C.B. (1996). Fetal auditory evoked responses detected by magnetoencephalography. Am. J. Obstet. Gynecol. 74:1484–1486.
Wakai, R.T., Leuthold, A.C., Weber, S., and Martin, C.B. (1999). MEG of the neonate during sleep. In: Yoshimoto, T., Kotani, M., Kuriki, S., Karibe, H., and Nakasato, N. (eds.), Recent Advances in Biomagnetism. Tohoku University Press, Sendai, pp. 978–981.
Wolf, D.P., Meng, L., Ouhibi, N., and Zelinski-Wooten, M. (1999). Nuclear transfer in the rhesus monkey: Practical and basic implications. Biol. Reprod. 60:199–204.
Worlein, J.M., and Sackett, G.P. (1995). Maternal exposure to stress during pregnancy: Its significance for infant behavior in pigtail macaques. In: Pryce, C.R., and Martin, R.D. (eds.), Motherhood in Human and Nonhuman Primates: Biosocial Determinants. Karger, Basel, pp. 142–151.
Yoshinaga K., Hess, D.L., Hendricks, A.G., and Zamboni L. (1988). The development of the sexually indifferent gonad in the prosimian, Galago crassicaudatus crassicaudatus. Am. J. Anat. 181:89–105.
Yoshinaga, K., Hess, D.L., Hendrickx, A.G., and Zamboni, L. (1990). Germinal cell ectopism in the strepsirhine prosimian Galago crassicaudatus crassicaudatus. Am. J. Anat. 187:213–231.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer Science+Business Media, Inc.
About this chapter
Cite this chapter
Xavier Novak, M.F.S. (2006). Very Early Rearing Experience: Rationale and Methodologies for Studying Prenatal Development in Nonhuman Primates. In: Sackett, G.P., Ruppentahal, G.C., Elias, K. (eds) Nursery Rearing of Nonhuman Primates in the 21st Century. Developments in Primatology: Progress and Prospects. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-25640-5_5
Download citation
DOI: https://doi.org/10.1007/978-0-387-25640-5_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-0-387-25632-0
Online ISBN: 978-0-387-25640-5
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)