Skip to main content

Ewing’s Sarcoma

  • Chapter
  • 1048 Accesses

Part of the book series: M.D. Anderson Cancer Care Series ((MDCCS,volume 4))

Abstract

Optimal management of Ewing’s sarcoma requires the comprehensive efforts of a multidisciplinary team of clinicians who understand the potential benefits and consequences of each treatment modality. Every effort should be made to enroll patients in prospective clinical trials to ensure appropriate quality assurance and standards of care. With current improvements in overall survival rates and the increasing number of patients living to adulthood, the need for long-term follow-up and surveillance for potential adverse effects must be emphasized. Although surgery is the preferred method of achieving local control, radiotherapy remains an integral component of the Ewing’s sarcoma treatment plan, and as new technology becomes available, ongoing research efforts will focus on reducing acute and long-term toxic effects and improving tumor control.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Readings

  • Ahrens S, Hoffmann C, Jabar S, et al. Evaluation of prognostic factors in a tumor volume-adapted treatment strategy for localized Ewing sarcoma of bone: the CESS 86 experience. Cooperative Ewing Sarcoma Study. Med Pediatr Oncol 1999;32:186–195.

    Article  CAS  PubMed  Google Scholar 

  • Bacci G, Picci P, Ruggieri P, et al. No advantages in the addition of ifosfamide and VP-16 to the standard four-drug regimen in the maintenance phase of neoadjuvant chemotherapy of Ewing’s Sarcoma of bone: Results of two sequential studies. J Chemother 1993;5:247–257.

    CAS  PubMed  Google Scholar 

  • Burgert EO, Jr., Nesbit ME, Garnsey LA, et al. Multimodal therapy for the management of nonpelvic, localized Ewing’s sarcoma of bone: intergroup study IESS-II. J Clin Oncol 1990;8:1514–1524.

    PubMed  Google Scholar 

  • Cotterill SJ, Ahrens S, Paulussen M, et al. Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing’s Sarcoma Study Group. J Clin Oncol 2000;18:3108–3114.

    CAS  PubMed  Google Scholar 

  • Craft AW, Cotterill SJ, Bullimore JA, et al. Long-term results from the first UKCCSG Ewing’s Tumour Study (ET-1). United Kingdom Children’s Cancer Study Group (UKCCSG) and the Medical Research Council Bone Sarcoma Working Party. Eur J Cancer 1997;33:1061–1069.

    Article  CAS  PubMed  Google Scholar 

  • Delattre O, Zucman J, Melot T, et al. The Ewing family of tumors a subgroup of small-round-cell tumors defined by specific chimeric transcripts. N Engl J Med 1994;331:294–299.

    Article  CAS  PubMed  Google Scholar 

  • Dominikus M, Windhager R, Kotz R. Treatment of malignant bone tumors in young children-complications and revisions. Acta Orthop Scand 1997;276 (4 Suppl).

    Google Scholar 

  • Donaldson SS, Torrey M, Link MP, et al. A multidisciplinary study investigating radiotherapy in Ewing’s sarcoma: end results of POG #8346. Pediatric Oncology Group. Int J Radiat Oncol Biol Phys 1998;42:125–135.

    CAS  PubMed  Google Scholar 

  • Dunst J, Ahrens S, Paulussen M, et al. Second malignancies after treatment for Ewing’s sarcoma: a report of the CESS-studies. Int J Radiat Oncol Biol Phys 1998;42:379–384.

    CAS  PubMed  Google Scholar 

  • Eckardt JJ, Kabo JM, Kelley CM, et al. Expandable endoprosthesis reconstruction in skeletally immature patients with tumors. Clin Orthop 2000;Apr:51–61.

    Google Scholar 

  • Elomaa I, Blomqvist CP, Saeter G, et al. Five-year results in Ewing’s sarcoma. The Scandinavian Sarcoma Group experience with the SSG IX protocol. Eur J Cancer 2000; 36:875–80.

    Article  CAS  PubMed  Google Scholar 

  • Evans RG, Nesbit ME, Gehan EA et al. Multimodal therapy for the management of localized Ewing’s sarcoma of pelvic and sacral bones: A report from the second Intergroup Study. J Clin Oncol 1991:9:1173–1180.

    CAS  PubMed  Google Scholar 

  • Fuchs B, Valenzuela RG, Inwards C, et al. Complications in long-term survivors of Ewing sarcoma. Cancer 2003;98:2687–2692.

    Article  PubMed  Google Scholar 

  • Grier HE, Krailo MD, Tarbell NJ, et al. Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. N Engl J Med 2003;348:694–701.

    Article  CAS  PubMed  Google Scholar 

  • Hanlon M, Krajbich JI: Rotationplasty in skeletally immature patients. Long-term followup results. Clin Orthop 1999;Jan:75–82.

    Google Scholar 

  • Hoffman C, Hillmann A, Krakau H, et al. Functional results and quality of life measurements in patients with multimodal treatment of a primary bone tumor located in the distal femur. Rotationplasty versus endoprosthetic replacement. Med Pediatr Oncol 1998;31:202–203.

    Google Scholar 

  • Hornicek FJ, Gebhardt MC, Tomford WW, et al. Factors affecting nonunion of the allograft-host junction. Clin Orthop 2001;Jan:87–98.

    Google Scholar 

  • Kenan S, Lewis MM, Peabody TD. Special considerations for growing children. In: Simon MA, Springfield D, eds. Surgery for Bone and Soft-Tissue Tumors. Philadelphia: Lippincott-Raven Publishers; 1998:245–262.

    Google Scholar 

  • Kushner BH, Meyers PA, Gerald WL, et al. Very-high-dose short-term chemotherapy for poor-risk peripheral primitive neuroectodermal tumors, including Ewing’s sarcoma, in children and young adults. J Clin Oncol 1995;13:2796–2804.

    CAS  PubMed  Google Scholar 

  • Nesbit ME, Jr., Gehan EA, Burgert EO, Jr., et al. Multimodal therapy for the management of primary, nonmetastatic Ewing’s sarcoma of bone: a long-term follow-up of the First Intergroup study. J Clin Oncol 1990;8:1664–1674.

    PubMed  Google Scholar 

  • Paulussen M, Ahrens S, Burdach S, et al. Primary metastatic (stage IV) Ewing tumor: survival analysis of 171 patients from the EICESS studies. European Intergroup Cooperative Ewing Sarcoma Studies. Ann Oncol 1998;9:275–281.

    Article  CAS  PubMed  Google Scholar 

  • Paulussen M, Ahrens S, Dunst J, et al. Localized Ewing tumor of bone: Final results of the Cooperative Ewing’s Sarcoma Study CESS 86. J Clin Oncol 2001;19:1818–1839.

    CAS  PubMed  Google Scholar 

  • Picci P, Bohling T, Bacci G, et al. Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing’s sarcoma of the extremities. J Clin Oncol 1997;15:1553–1559.

    CAS  PubMed  Google Scholar 

  • Sailer, SL, Harmon, D.C., Mankin, H.J., et al. Ewing’s sarcoma: Surgical resection as a prognostic factor. Int J Radiat Oncol Biol Phys 1988;15:43–52.

    CAS  PubMed  Google Scholar 

  • Schiller C, Windhager R, Fellinger EJ, Salzer-Kuntschik M, Kaider A, Kotz R. Extendable tumour endoprostheses for the leg in children. J Bone Joint Surg Br 1995;77:608–614.

    CAS  PubMed  Google Scholar 

  • Schuck A, Ahrens S, Paulussen M, et al. Local therapy in localized Ewing tumors: Results of 1058 patients treated in the CESS 81, CESS 86, and EICESS 92 trials. Int J Radiat Oncol Biol Phys 2003;55:168–177.

    Article  PubMed  Google Scholar 

  • Vosika GJ, Cornelius, D.A., Bennek, J.A., et al. Immunologic and toxicologic study of disaccharide tripeptide glycerol dipalmitoyl: A new lipophilic immunomodulator. Mol Biother 1990;2:50–56.

    CAS  PubMed  Google Scholar 

  • Vosika, G.J., Cornelius, D.A., Gilbert, C.W., et al. Phase I Trial of ImmTher, a new liposome-incorporated lipophilic disaccharide tripeptide. J Immunother 1991;10:256–266.

    Article  CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Herzog, C.E., Mahajan, A., Lewis, V.O. (2005). Ewing’s Sarcoma. In: Chan, K.W., Raney, R.B. (eds) Pediatric Oncology. M.D. Anderson Cancer Care Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-24472-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-24472-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-24470-9

  • Online ISBN: 978-0-387-24472-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics