Skip to main content

Osteosarcoma

  • Chapter
Pediatric Oncology

Part of the book series: M.D. Anderson Cancer Care Series ((MDCCS,volume 4))

  • 1050 Accesses

Abstract

At M. D. Anderson Cancer Center, intra-arterial cisplatin, intravenous doxorubicin, high-dose methotrexate, and ifosfamide constitute the mainstay of treatment for children with osteosarcoma. Limb salvage or amputation is performed to extirpate the primary tumor. To achieve cure in patients with pulmonary metastases, surgical intervention is required in addition to chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Readings

  • Benjamin RS, Chawla SP, Murray J, et al. Preoperative chemotherapy for osteosarcoma: a treatment approach facilitating limb salvage with major prognostic indications. In: Jones SF, Salmon SE, eds. Adjuvant Therapy of Cancer IV. Philadelphia, PA: Grune and Stratton; 1984:601–610.

    Google Scholar 

  • Hudson M, Jaffe MR, Jaffe N, et al. Pediatric osteosarcoma: therapeutic strategies, results and prognostic factors derived from a 10-year experience. J Clin Oncol 1990;8:1988–1997.

    CAS  PubMed  Google Scholar 

  • Jaffe N. Chemotherapy in osteosarcoma: advances and controversies. In: Muggia FM, ed. Experimental and Clinical Progress in Cancer Chemotherapy. Boston, MA: Martinus Nijholl; 1985:223–233.

    Google Scholar 

  • Jaffe N, Carrasco H, Raymond K, et al. Can cure in patients with osteosarcoma be achieved exclusively with chemotherapy and abrogation of surgery? Cancer 2002;95:2202–2210.

    Article  PubMed  Google Scholar 

  • Jaffe N, Knapp J, Chuang VP, et al. Osteosarcoma: intra-arterial treatment of the primary tumor with cis-diammine-dichloroplatinum II (CDP). Angiographic, pathologic, and pharmacologic studies. Cancer 1983;51:402–407.

    Article  CAS  PubMed  Google Scholar 

  • Jaffe N, Smith E, Abelson HT, Frei S. Osteogenic sarcoma: adjuvant chemotherapy. J Clin Oncol 1983;1:251–254.

    CAS  PubMed  Google Scholar 

  • Meyers PA, Heller G, Healey J, et al. Chemotherapy for nonmetastatic osteogenic sarcoma: the Memorial Sloan-Kettering Experience. J Clin Oncol 1992;10:5–13.

    CAS  PubMed  Google Scholar 

  • Rosen G, Caparros B, Huvos AG, et al. Preoperative chemotherapy for osteogenic sarcoma. Selection of post-operative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy. Cancer 1983;49:1221–1230.

    Article  Google Scholar 

  • Sutow WW, Gehan EA, Kijmert PA, et al. Multidrug adjuvant chemotherapy for osteosarcoma: interim report of the Southwest Oncology Group Studies. Cancer Treat Rep 1978;62:265–270.

    CAS  PubMed  Google Scholar 

  • Winkler K, Beron G, Dellinger G, et al. Neoadjuvant chemotherapy of osteosarcoma: results of a randomized cooperative trial (COSS-82) with salvage chemotherapy varied on histological tumor response. J Clin Oncol 1988;6:329–337.

    CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Jaffe, N., Pearson, M.G. (2005). Osteosarcoma. In: Chan, K.W., Raney, R.B. (eds) Pediatric Oncology. M.D. Anderson Cancer Care Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-24472-3_8

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-24472-3_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-24470-9

  • Online ISBN: 978-0-387-24472-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics