Skip to main content

Retinoblastoma

  • Chapter
Pediatric Oncology

Part of the book series: M.D. Anderson Cancer Care Series ((MDCCS,volume 4))

  • 1032 Accesses

Abstract

This chapter will review the presentation, epidemiology, workup, and treatment modalities available to children with retinoblastoma. Current approaches include the use of systemic chemotherapy combined with adjuvant techniques to treat intraocular disease, reducing the need for external-beam radiotherapy. A multidisciplinary approach in which the expertise of pediatric oncologists, ophthalmologists, radiation oncologists, and geneticists is combined generally works best.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Suggested Readings

  • Abramson DH, Frank CM. Second nonocular tumors in survivors of bilateral retinoblastoma: a possible age effect on radiation-related risk. Ophthalmology 1998;105:573–580.

    Article  CAS  PubMed  Google Scholar 

  • Abramson DH, Frank CM, Dunkel IJ. A phase I/II study of subconjunctival carboplatin for intraocular retinoblastoma. Ophthalmology 1999;106:1947–1950.

    Article  CAS  PubMed  Google Scholar 

  • Augsburger JJ, Oehlschläger U, Manzitti JE, et al. Multinational clinical and pathologic registry of retinoblastoma: Retinoblastoma International Collaborative Study report 2. Graefes Arch Clin Exp Ophthalmol 1995;233:469–475.

    Article  CAS  PubMed  Google Scholar 

  • Bagley LJ, Hurst RW, Zimmerman RA, et al. Imaging in the trilateral retinoblastoma syndrome. Neuroradiology 1996;38:166–170.

    Article  CAS  PubMed  Google Scholar 

  • Balmer A, Munier F, Gailloud C. Retinoma: case studies. Ophthalmic Paediatrics and Genetics 1991;12:131–137.

    Article  CAS  PubMed  Google Scholar 

  • Damato B. Retinoblastoma. In: Damato B. Ocular Tumours: Diagnosis and Treatment. Oxford, UK: Butterworth-Heinemann; 2000:127–149.

    Google Scholar 

  • DiCiommo D, Gallie BL, Bremner R. Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer. Semin Cancer Biol 2000;10:255–269.

    Article  CAS  PubMed  Google Scholar 

  • Draper GJ, Sanders BM, Brownbill PA. Patterns of risk and hereditary retinoblastoma and applications to genetic counseling. Br J Cancer 1992;66:211–219.

    CAS  PubMed  Google Scholar 

  • Ellsworth RM. Retinoblastoma: an overview. In: Blodi FC, ed. Contemporary Issues in Ophthalmology, vol 2. New York, NY: Churchill Livingstone; 1985:1–10.

    Google Scholar 

  • Eng C, Li FP, Abramson DH, et al. Mortality from second tumors among long-term survivors of retinoblastoma. J Natl Cancer Inst 1993;85:1121–1128.

    Article  CAS  PubMed  Google Scholar 

  • Gallie BL, Budnig A, DeBoer G, et al. Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol 1996;114:1321–1328.

    CAS  PubMed  Google Scholar 

  • Gallie BL, Phillips RA, Ellsworth RM, et al. Significance of retinoma and phthisis bulbi for retinoblastoma. Ophthalmology 1982;89:1393–1399.

    CAS  PubMed  Google Scholar 

  • Gurney JG, Ross JA, Wall DA, et al. Infant cancer in the U.S.: histology-specific incidence and trends, 1973 to 1992. J Pediatr Hematol Oncol 1997;19:428–432.

    Article  CAS  PubMed  Google Scholar 

  • Harbour JW. Overview of Rb gene mutations in patients with retinoblastoma: implications for clinical genetic screening. Ophthalmology 1998;105:1442–1447.

    Article  CAS  PubMed  Google Scholar 

  • Harbour JW. Retinoblastoma: pathogenesis and diagnosis. In: Char DH. Tumors of the Eye and Ocular Adnexa. Hamilton, ON, Canada: BC Decker; 2001a:253–265.

    Google Scholar 

  • Harbour JW. Retinoblastoma: treatment. In: Char DH. Tumors of the Eye and Ocular Adnexa. Hamilton, ON, Canada: BC Decker; 2001b:266–278.

    Google Scholar 

  • Hayden BH, Murray TG, Scott IU, et al. Subconjunctival carboplatin in retinoblastoma: impact of tumor burden and dose schedule. Arch Ophthalmol 2000;118:1549–1554.

    CAS  PubMed  Google Scholar 

  • Kingston JE, Hungerford JL, Madreperla SA, et al. Results of combined chemotherapy and radiotherapy for advanced intraocular retinoblastoma. Arch Ophthalmol 1996;114:1339–1343.

    CAS  PubMed  Google Scholar 

  • Kingston JE, Hungerford JL, Plowman PN. Chemotherapy in metastatic retinoblastoma. Ophthalmic Paediatrics and Genetics 1987;8:69–72.

    Article  CAS  PubMed  Google Scholar 

  • Knudson AG. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971;68:820–823.

    Article  PubMed  Google Scholar 

  • Marcus DM, Brooks SE, Leff G, et al. Trilateral retinoblastoma: insights into histogenesis and management. Surv Ophthalmol 1998;43:59–70.

    Article  CAS  PubMed  Google Scholar 

  • Messmer EP, Heinrich T, Höpping W, et al. Risk factors for metastasis in patients with retinoblastoma. Ophthalmology 1991;98:136–141.

    CAS  PubMed  Google Scholar 

  • Murphree AL, Villablanca JG, Deegan WF, et al. Chemotherapy plus local treatment in the management of intraocular retinoblastoma. Arch Ophthalmol 1996;114:1348–1356.

    CAS  PubMed  Google Scholar 

  • Saarinen UM, Sariola H, Hovi L. Recurrent disseminated retinoblastoma treated by high-dose chemotherapy, total body irradiation, and autologous bone marrow rescue. Am J Pediatr Hematol Oncol 1991;13:315–319.

    Article  CAS  PubMed  Google Scholar 

  • Shields CL, De Potter P, Himelstein BP, et al. Chemoreduction in the initial management of intraocular retinoblastoma. Arch Ophthalmol 1996;114:1330–1338.

    CAS  PubMed  Google Scholar 

  • Shields CL, Santos MCM, Diniz W, et al. Thermotherapy for retinoblastoma. Arch Ophthalmol 1999;117:885–893.

    CAS  PubMed  Google Scholar 

  • Shields CL, Shields JA. Recent developments in the management of retinoblastoma. J Pediatr Ophthalmol Strabismus 1999;36:8–18.

    CAS  PubMed  Google Scholar 

  • Shields CL, Shields JA, De Potter P, et al. Plaque radiotherapy in the management of retinoblastoma: use as a primary and secondary treatment. Ophthalmology 1993;100:216–224.

    CAS  PubMed  Google Scholar 

  • Singh AD, Shields CL, Shields JA. Prognostic factors in retinoblastoma. J Pediatr Ophthalmol Strabismus 2000; 37:134–141.

    CAS  PubMed  Google Scholar 

  • Stallard, HB. The conservative treatment of retinoblastoma. Trans Ophthalmol Soc U K 1962;82:473–534.

    CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer Science+Business Media, Inc.

About this chapter

Cite this chapter

Faustina, M., Herzog, C.E., Gombos, D.S. (2005). Retinoblastoma. In: Chan, K.W., Raney, R.B. (eds) Pediatric Oncology. M.D. Anderson Cancer Care Series, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-24472-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-0-387-24472-3_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-24470-9

  • Online ISBN: 978-0-387-24472-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics