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Wild Types and Mutants

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Abstract

Genetic analysis of any organism requires genetic variation. The originator of the science, Gregor Mendel, recognized this, and the two features of his work that made it so revolutionary were the fact that he counted progeny, and he used heritable characteristics that had two contrasting phenotypes.

Keywords

Minimal Medium Frameshift Mutation Neurospora Crassa Pyrimidine Dimer Reverse Mutation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Publications and Websites Worth a Visit

  1. Authoritative information about numerous carcinogens and mutagens can be found in the Ninth Report on Carcinogens (as revised January 2001), which is produced regularly by the U.S. Department of Health and Human Services in the Public Health Service National Toxicology Program. The current report can be accessed and downloaded from http://ehis.niehs.nih.gov/roc/.
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  4. The Environmental Mutagen Society (EMS) is the primary scientific society fostering research on the basic mechanisms of mutagenesis as well as on the application of this knowledge in the field of genetic toxicology. The EMS website is at http://www.ems-us.org.
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  7. Mutation Research is a research journal that published a special issue entitled Fundamental and Molecular Mechanisms of Mutagenesis in November 2000 (Mutation Research Volume 455, Issues 1-2, pp. 1–215). This is expected to be the first volume in an Elsevier series on Protocols in Mutagenesis, and contains 13 papers providing bench-level details for studies using different mutagenesis assay systems.Google Scholar
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  10. Risk Management Internet Services provides a family of resources for risk management at http://rmis.com. Features on offer include a listing of databases dealing with chemicals at http://rmis.com/sites/cheatab.htm.
  11. Sanchez, O., Navarro, R.E. & Aguirre, J. (1998). Increased transformation frequency and tagging of developmental genes in Aspergillus nidulans by restriction enzyme-mediated integration (REMI). Molecular and General Genetics 258, (1998).Google Scholar
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Historical Publications Worth Knowing About

  1. Evans, H.J. & Lloyd, D.C. (1978). Mutagen-Induced Chromosome Damage in Man. Ednburgh University Press: Edinburgh.Google Scholar
  2. Holliday, R. (1956). A new method for the identification of biochemical mutants of micro-organisms. Nature 178, 987.CrossRefGoogle Scholar
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  4. Wood, R.D. & Sedgwick, S.G. (1986). Molecular aspects of mutagenesis. Mutagenesis 1, 399–405.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 2002

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