Genetic analysis of any organism requires genetic variation. The originator of the science, Gregor Mendel, recognized this, and the two features of his work that made it so revolutionary were the fact that he counted progeny, and he used heritable characteristics that had two contrasting phenotypes.
KeywordsMinimal Medium Frameshift Mutation Neurospora Crassa Pyrimidine Dimer Reverse Mutation
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Publications and Websites Worth a Visit
- Authoritative information about numerous carcinogens and mutagens can be found in the Ninth Report on Carcinogens (as revised January 2001), which is produced regularly by the U.S. Department of Health and Human Services in the Public Health Service National Toxicology Program. The current report can be accessed and downloaded from http://ehis.niehs.nih.gov/roc/.
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- Mutation Research is a research journal that published a special issue entitled Fundamental and Molecular Mechanisms of Mutagenesis in November 2000 (Mutation Research Volume 455, Issues 1-2, pp. 1–215). This is expected to be the first volume in an Elsevier series on Protocols in Mutagenesis, and contains 13 papers providing bench-level details for studies using different mutagenesis assay systems.Google Scholar
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- Risk Management Internet Services provides a family of resources for risk management at http://rmis.com. Features on offer include a listing of databases dealing with chemicals at http://rmis.com/sites/cheatab.htm.
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- TOXNET is a website giving access to a cluster of databases on toxicology, hazardous chemicals, and related areas that provide factual information on toxicity and other hazards of chemicals. The website is at http://toxnet.nlm.nih.gov/.