Wild Types and Mutants



Genetic analysis of any organism requires genetic variation. The originator of the science, Gregor Mendel, recognized this, and the two features of his work that made it so revolutionary were the fact that he counted progeny, and he used heritable characteristics that had two contrasting phenotypes.


Minimal Medium Frameshift Mutation Neurospora Crassa Pyrimidine Dimer Reverse Mutation 
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Publications and Websites Worth a Visit

  1. Authoritative information about numerous carcinogens and mutagens can be found in the Ninth Report on Carcinogens (as revised January 2001), which is produced regularly by the U.S. Department of Health and Human Services in the Public Health Service National Toxicology Program. The current report can be accessed and downloaded from
  2. Bos, C.J. & Stadler, D. (1996). Mutation. In Fungal Genetics: Principles and Practice (C.J. Bos, ed.), pp. 13–42. Marcel Dekker, Inc.: New York.Google Scholar
  3. Cummings, W.J., Celerin, M., Crodian, X, Brunick, L.K. & Zolan, M.E. (1999). Insertional mutagenesis in Coprinus cinereus: use of a dominant selectable marker to generate tagged, sporulation-defective mutants. Current Genetics 36, 371–382.PubMedCrossRefGoogle Scholar
  4. The Environmental Mutagen Society (EMS) is the primary scientific society fostering research on the basic mechanisms of mutagenesis as well as on the application of this knowledge in the field of genetic toxicology. The EMS website is at
  5. Granado, J.D., Kertesz-Chaloupková, K., Aebi, M. & Köues, U. (1997). Restriction enzyme-mediated DNA integration in Coprinus cinereus. Molecular and General Genetics 256, 28–36.PubMedCrossRefGoogle Scholar
  6. Kahmann, R. & Basse, C. (1999). REMI (restriction enzyme mediated integration) and its impact on the isolation of pathogenicity genes in fungi attacking plants. European Journal of Plant Pathology 105, 221–229.CrossRefGoogle Scholar
  7. Mutation Research is a research journal that published a special issue entitled Fundamental and Molecular Mechanisms of Mutagenesis in November 2000 (Mutation Research Volume 455, Issues 1-2, pp. 1–215). This is expected to be the first volume in an Elsevier series on Protocols in Mutagenesis, and contains 13 papers providing bench-level details for studies using different mutagenesis assay systems.Google Scholar
  8. Pukkila, P.J. (1996). Production and analysis of meiotic mutants in Coprinus cinereus. In Fungal Genetics: Principles and Practice (C.J. Bos, ed.), pp. 363–369. Marcel Dekker, Inc.: New York.Google Scholar
  9. Radford, A., Bruchez, J.J.P., Taleb, F. & Stone, P.J. (1996). Mutation in Neurospora crassa: from X-rays to RIP. In Fungal Genetics: Principles and Practice (C.J. Bos, ed.), pp. 281–294. Marcel Dekker, Inc.: New York.Google Scholar
  10. Risk Management Internet Services provides a family of resources for risk management at Features on offer include a listing of databases dealing with chemicals at
  11. Sanchez, O., Navarro, R.E. & Aguirre, J. (1998). Increased transformation frequency and tagging of developmental genes in Aspergillus nidulans by restriction enzyme-mediated integration (REMI). Molecular and General Genetics 258, (1998).Google Scholar
  12. Sweigard, J.A., Caroll, A.M., Farrall, L., Chumley, EG. & Valent, B. (1998). Magnaporthe grisea pathogenicity genes obtained through Insertional mutagenesis. Molecular Plant-Microbe Interactions 11, 404–412.PubMedCrossRefGoogle Scholar
  13. TOXNET is a website giving access to a cluster of databases on toxicology, hazardous chemicals, and related areas that provide factual information on toxicity and other hazards of chemicals. The website is at
  14. Wright, B.E. (2000). A biochemical mechanism for nonrandom mutations and evolution. Journal of Bacteriology 182, 2993–3001.PubMedCrossRefGoogle Scholar

Historical Publications Worth Knowing About

  1. Evans, H.J. & Lloyd, D.C. (1978). Mutagen-Induced Chromosome Damage in Man. Ednburgh University Press: Edinburgh.Google Scholar
  2. Holliday, R. (1956). A new method for the identification of biochemical mutants of micro-organisms. Nature 178, 987.CrossRefGoogle Scholar
  3. Venitt, S. & Parr, J.M. (1984). Mutagenicity Testing: A Practical Approach. IRL Press: Oxford, UK.Google Scholar
  4. Wood, R.D. & Sedgwick, S.G. (1986). Molecular aspects of mutagenesis. Mutagenesis 1, 399–405.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag New York, Inc. 2002

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